Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent

Detalhes bibliográficos
Autor(a) principal: Almeida, Maria G.J. [UNESP]
Data de Publicação: 2012
Outros Autores: Teixeira, Marcos F.S. [UNESP], Marques Gomes, Homero [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/220014
Resumo: A flow injection spectrophotometric method was developed for the determination of acetazolamide, (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide), in commercial anti-hypertensive drugs. The new and simple procedure is based on the reaction between sulfonamide groups and permanganate ions in an alkaline medium. The results showed that linear quantification of acetazolamide could be achieved at two wavelengths. A decrease of the permanganate concentration could be measured at 530 nm, while an increase in manganate concentration could be measured at 610 nm, in the concentration ranges from 1.0 × 10-5 to 2.5 × 10-4 mol L-1 and from 2.5 × 10-5 to 2.5 × 10-4 mol L-1, respectively. The detection limits were 4.5 × 10-6 mol L-1 (530 nm) and 2.2 × 10-6 mol L-1 (610 nm). The usual excipients used in commercial drugs did not interfere in the determinations, and the results were consistent with those obtained by a UV reference technique.
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spelling Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagentAcetazolamideFlow injectionPermanganateSpectrophotometric determinationA flow injection spectrophotometric method was developed for the determination of acetazolamide, (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide), in commercial anti-hypertensive drugs. The new and simple procedure is based on the reaction between sulfonamide groups and permanganate ions in an alkaline medium. The results showed that linear quantification of acetazolamide could be achieved at two wavelengths. A decrease of the permanganate concentration could be measured at 530 nm, while an increase in manganate concentration could be measured at 610 nm, in the concentration ranges from 1.0 × 10-5 to 2.5 × 10-4 mol L-1 and from 2.5 × 10-5 to 2.5 × 10-4 mol L-1, respectively. The detection limits were 4.5 × 10-6 mol L-1 (530 nm) and 2.2 × 10-6 mol L-1 (610 nm). The usual excipients used in commercial drugs did not interfere in the determinations, and the results were consistent with those obtained by a UV reference technique.Department of Physics Chemistry and Biology University of the State of São Paulo (UNESP)Department of Physics Chemistry and Biology University of the State of São Paulo (UNESP)Universidade Estadual Paulista (UNESP)Almeida, Maria G.J. [UNESP]Teixeira, Marcos F.S. [UNESP]Marques Gomes, Homero [UNESP]2022-04-28T18:59:11Z2022-04-28T18:59:11Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article374-379Brazilian Journal of Analytical Chemistry, v. 3, n. 9, p. 374-379, 2012.2179-34332179-3425http://hdl.handle.net/11449/2200142-s2.0-84892143156Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Analytical Chemistryinfo:eu-repo/semantics/openAccess2022-04-28T18:59:11Zoai:repositorio.unesp.br:11449/220014Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:29:30.280829Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
title Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
spellingShingle Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
Almeida, Maria G.J. [UNESP]
Acetazolamide
Flow injection
Permanganate
Spectrophotometric determination
title_short Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
title_full Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
title_fullStr Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
title_full_unstemmed Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
title_sort Spectrophotometric determination of acetazolamide using a flow injection system with KMnO4 reagent
author Almeida, Maria G.J. [UNESP]
author_facet Almeida, Maria G.J. [UNESP]
Teixeira, Marcos F.S. [UNESP]
Marques Gomes, Homero [UNESP]
author_role author
author2 Teixeira, Marcos F.S. [UNESP]
Marques Gomes, Homero [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Almeida, Maria G.J. [UNESP]
Teixeira, Marcos F.S. [UNESP]
Marques Gomes, Homero [UNESP]
dc.subject.por.fl_str_mv Acetazolamide
Flow injection
Permanganate
Spectrophotometric determination
topic Acetazolamide
Flow injection
Permanganate
Spectrophotometric determination
description A flow injection spectrophotometric method was developed for the determination of acetazolamide, (N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide), in commercial anti-hypertensive drugs. The new and simple procedure is based on the reaction between sulfonamide groups and permanganate ions in an alkaline medium. The results showed that linear quantification of acetazolamide could be achieved at two wavelengths. A decrease of the permanganate concentration could be measured at 530 nm, while an increase in manganate concentration could be measured at 610 nm, in the concentration ranges from 1.0 × 10-5 to 2.5 × 10-4 mol L-1 and from 2.5 × 10-5 to 2.5 × 10-4 mol L-1, respectively. The detection limits were 4.5 × 10-6 mol L-1 (530 nm) and 2.2 × 10-6 mol L-1 (610 nm). The usual excipients used in commercial drugs did not interfere in the determinations, and the results were consistent with those obtained by a UV reference technique.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2022-04-28T18:59:11Z
2022-04-28T18:59:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Brazilian Journal of Analytical Chemistry, v. 3, n. 9, p. 374-379, 2012.
2179-3433
2179-3425
http://hdl.handle.net/11449/220014
2-s2.0-84892143156
identifier_str_mv Brazilian Journal of Analytical Chemistry, v. 3, n. 9, p. 374-379, 2012.
2179-3433
2179-3425
2-s2.0-84892143156
url http://hdl.handle.net/11449/220014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Analytical Chemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 374-379
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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