Melatonin and circadian rhythms in autism: Case report
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/07420528.2017.1308375 http://hdl.handle.net/11449/178848 |
Resumo: | Among the most co-occurring conditions in autism spectrum disorders (ASD), there are sleep disorders which may exacerbate associated behavioral disorders and lead to intensification of existing autistic symptoms. Several studies investigating the use of melatonin in the treatment of sleep disorders in ASD have shown comparative efficiency in sleep with little or no side effects. Here we report a case of ASD with non-24-hour rhythm and the effect of melatonin in circadian parameters by actigraphy. Visual analysis of the first 10 days recorded and the periodogram suggest that this patient showed a non-24-hour rhythm. This ASD subject showed before melatonin administration an activity/rest rhythm lower than 24 hours. The results show that melatonin increased approximately 4.7 times the regularity of circadian activity rhythm and resting staying on average between 00:00 and 06:00 and showed positive effects in improving the quality of sleep and behavior. So, the actigraphy showed an ASD subject with a non-24-hour activity/rest rhythm which changed this rhythm to a 24-hour rhythm after melatonin administration. This result reinforces the prospect of therapy with melatonin for synchronization (increased regularity) of endogenous rhythms and improve sleep quality and hence behavior and indicates the actigraphy as a choice tool to characterize several parameters of the activity/rest rhythm of ASD individuals. |
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Melatonin and circadian rhythms in autism: Case reportactigraphybehaviorNeurodevelopmental disordersleepAmong the most co-occurring conditions in autism spectrum disorders (ASD), there are sleep disorders which may exacerbate associated behavioral disorders and lead to intensification of existing autistic symptoms. Several studies investigating the use of melatonin in the treatment of sleep disorders in ASD have shown comparative efficiency in sleep with little or no side effects. Here we report a case of ASD with non-24-hour rhythm and the effect of melatonin in circadian parameters by actigraphy. Visual analysis of the first 10 days recorded and the periodogram suggest that this patient showed a non-24-hour rhythm. This ASD subject showed before melatonin administration an activity/rest rhythm lower than 24 hours. The results show that melatonin increased approximately 4.7 times the regularity of circadian activity rhythm and resting staying on average between 00:00 and 06:00 and showed positive effects in improving the quality of sleep and behavior. So, the actigraphy showed an ASD subject with a non-24-hour activity/rest rhythm which changed this rhythm to a 24-hour rhythm after melatonin administration. This result reinforces the prospect of therapy with melatonin for synchronization (increased regularity) of endogenous rhythms and improve sleep quality and hence behavior and indicates the actigraphy as a choice tool to characterize several parameters of the activity/rest rhythm of ASD individuals.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista (UNESP)Escola de Artes Ciências e Humanidades–Universidade de São PauloLaboratório de Dificuldades e Distúrbios da Aprendizagem e Transtornos da Atenção-UNICAMPUniversidade Estadual Paulista (UNESP)CNPq: 166068 / 2015-2FAPESP: 2011/51495-4Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Universidade Estadual de Campinas (UNICAMP)Zuculo, Gabriela Melloni [UNESP]Gonçalves, Bruno S.B.Brittes, ClayMenna-Barreto, LuizPinato, Luciana [UNESP]2018-12-11T17:32:23Z2018-12-11T17:32:23Z2017-04-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article527-530application/pdfhttp://dx.doi.org/10.1080/07420528.2017.1308375Chronobiology International, v. 34, n. 4, p. 527-530, 2017.1525-60730742-0528http://hdl.handle.net/11449/17884810.1080/07420528.2017.13083752-s2.0-850187339152-s2.0-85018733915.pdf8372363591179624Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChronobiology International1,086info:eu-repo/semantics/openAccess2024-08-09T17:39:46Zoai:repositorio.unesp.br:11449/178848Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:39:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Melatonin and circadian rhythms in autism: Case report |
title |
Melatonin and circadian rhythms in autism: Case report |
spellingShingle |
Melatonin and circadian rhythms in autism: Case report Zuculo, Gabriela Melloni [UNESP] actigraphy behavior Neurodevelopmental disorder sleep |
title_short |
Melatonin and circadian rhythms in autism: Case report |
title_full |
Melatonin and circadian rhythms in autism: Case report |
title_fullStr |
Melatonin and circadian rhythms in autism: Case report |
title_full_unstemmed |
Melatonin and circadian rhythms in autism: Case report |
title_sort |
Melatonin and circadian rhythms in autism: Case report |
author |
Zuculo, Gabriela Melloni [UNESP] |
author_facet |
Zuculo, Gabriela Melloni [UNESP] Gonçalves, Bruno S.B. Brittes, Clay Menna-Barreto, Luiz Pinato, Luciana [UNESP] |
author_role |
author |
author2 |
Gonçalves, Bruno S.B. Brittes, Clay Menna-Barreto, Luiz Pinato, Luciana [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Zuculo, Gabriela Melloni [UNESP] Gonçalves, Bruno S.B. Brittes, Clay Menna-Barreto, Luiz Pinato, Luciana [UNESP] |
dc.subject.por.fl_str_mv |
actigraphy behavior Neurodevelopmental disorder sleep |
topic |
actigraphy behavior Neurodevelopmental disorder sleep |
description |
Among the most co-occurring conditions in autism spectrum disorders (ASD), there are sleep disorders which may exacerbate associated behavioral disorders and lead to intensification of existing autistic symptoms. Several studies investigating the use of melatonin in the treatment of sleep disorders in ASD have shown comparative efficiency in sleep with little or no side effects. Here we report a case of ASD with non-24-hour rhythm and the effect of melatonin in circadian parameters by actigraphy. Visual analysis of the first 10 days recorded and the periodogram suggest that this patient showed a non-24-hour rhythm. This ASD subject showed before melatonin administration an activity/rest rhythm lower than 24 hours. The results show that melatonin increased approximately 4.7 times the regularity of circadian activity rhythm and resting staying on average between 00:00 and 06:00 and showed positive effects in improving the quality of sleep and behavior. So, the actigraphy showed an ASD subject with a non-24-hour activity/rest rhythm which changed this rhythm to a 24-hour rhythm after melatonin administration. This result reinforces the prospect of therapy with melatonin for synchronization (increased regularity) of endogenous rhythms and improve sleep quality and hence behavior and indicates the actigraphy as a choice tool to characterize several parameters of the activity/rest rhythm of ASD individuals. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-21 2018-12-11T17:32:23Z 2018-12-11T17:32:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/07420528.2017.1308375 Chronobiology International, v. 34, n. 4, p. 527-530, 2017. 1525-6073 0742-0528 http://hdl.handle.net/11449/178848 10.1080/07420528.2017.1308375 2-s2.0-85018733915 2-s2.0-85018733915.pdf 8372363591179624 |
url |
http://dx.doi.org/10.1080/07420528.2017.1308375 http://hdl.handle.net/11449/178848 |
identifier_str_mv |
Chronobiology International, v. 34, n. 4, p. 527-530, 2017. 1525-6073 0742-0528 10.1080/07420528.2017.1308375 2-s2.0-85018733915 2-s2.0-85018733915.pdf 8372363591179624 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chronobiology International 1,086 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
527-530 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128185954467840 |