Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride

• Autor(a) principal: Chiba, Fernando Yamamoto [UNESP]
• Data de Publicação: 2010
• Outros Autores: Colombo, Natalia Helena [UNESP], Shirakashi, Daisy Jaqueline [UNESP], de Souza Gomes, Wendrew Douglas [UNESP], Moimaz, Suzely Adas Saliba [UNESP], Garbin, Clea Adas Saliba [UNESP], Silva, Cristina Antoniali [UNESP], Sumida, Doris Hissako [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.fluorideresearch.org/431a/files/FJ2010_v43_n1_p00i-iii.pdf; http://hdl.handle.net/11449/14984
• topic: Fluoride; Insulin receptor substrate; Insulin sensitivity; Insulin signal; Rats and insulin

With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance.