Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10856-018-6146-1 http://hdl.handle.net/11449/171349 |
Resumo: | Fabricating novel materials for biomedical applications mostly require the use of biodegradable materials. In this work biodegradable materials like polylactic acid (PLA) and chitosan (CHS) were used for designing electrospun mats. This work reports the physical and chemical characterization of the PLA–CHS composite, prepared by the electrospinning technique using a mixed solvent system. The addition of chitosan into PLA, offered decrease in fiber diameter in the composites with uniformity in the distribution of fibers with an optimum at 0.4wt% CHS. The fiber formation and the reduction in fiber diameter were confirmed by the SEM micrograph. The inverse gas chromatography and contact angle measurements supported the increase of hydrophobicity of the composite membrane with increase of filler concentration. The weak interaction between PLA and chitosan was confirmed by Fourier transform infrared spectroscopy and thermal analysis. The stability of the composite was established by zeta potential measurements. Cytotoxicity studies of the membranes were also carried out and found that up to 0.6% CHS the composite material was noncytotoxic. The current findings are very important for the design and development of new materials based on polylactic acid-chitosan composites for environmental and biomedical applications. [Figure not available: see fulltext.]. |
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Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced applicationFabricating novel materials for biomedical applications mostly require the use of biodegradable materials. In this work biodegradable materials like polylactic acid (PLA) and chitosan (CHS) were used for designing electrospun mats. This work reports the physical and chemical characterization of the PLA–CHS composite, prepared by the electrospinning technique using a mixed solvent system. The addition of chitosan into PLA, offered decrease in fiber diameter in the composites with uniformity in the distribution of fibers with an optimum at 0.4wt% CHS. The fiber formation and the reduction in fiber diameter were confirmed by the SEM micrograph. The inverse gas chromatography and contact angle measurements supported the increase of hydrophobicity of the composite membrane with increase of filler concentration. The weak interaction between PLA and chitosan was confirmed by Fourier transform infrared spectroscopy and thermal analysis. The stability of the composite was established by zeta potential measurements. Cytotoxicity studies of the membranes were also carried out and found that up to 0.6% CHS the composite material was noncytotoxic. The current findings are very important for the design and development of new materials based on polylactic acid-chitosan composites for environmental and biomedical applications. [Figure not available: see fulltext.].University Grants CommissionInternational and Interuniversity Centre for Nanoscience and Nanotechnology Mahatma Gandhi University, Priyadarsini Hills P.O.Department of Chemistry Mar Thoma College, Kuttapuzha P.O.Department of Chemistry C.M.S. CollegeFood and Bioproduct Sciences University of SaskatchewanFaculty of Exact Science and Engineering University of MadeiraCIIMAR University of PortoInstitute of Chemistry-UNESP, CP 355, Zip 14801-970Institute of Chemistry-UNESP, CP 355, Zip 14801-970Mahatma Gandhi UniversityMar Thoma CollegeC.M.S. CollegeUniversity of SaskatchewanUniversity of MadeiraUniversity of PortoUniversidade Estadual Paulista (Unesp)Thomas, Merin SaraPillai, Prasanth K. S.Faria, MarisaCordeiro, NereidaBarud, Hernane [UNESP]Thomas, SabuPothen, Laly A.2018-12-11T16:54:59Z2018-12-11T16:54:59Z2018-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1007/s10856-018-6146-1Journal of Materials Science: Materials in Medicine, v. 29, n. 9, 2018.1573-48380957-4530http://hdl.handle.net/11449/17134910.1007/s10856-018-6146-12-s2.0-850517409402-s2.0-85051740940.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Materials Science: Materials in Medicine0,6470,647info:eu-repo/semantics/openAccess2023-12-11T06:15:07Zoai:repositorio.unesp.br:11449/171349Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:02:01.682707Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
title |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
spellingShingle |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application Thomas, Merin Sara |
title_short |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
title_full |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
title_fullStr |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
title_full_unstemmed |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
title_sort |
Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application |
author |
Thomas, Merin Sara |
author_facet |
Thomas, Merin Sara Pillai, Prasanth K. S. Faria, Marisa Cordeiro, Nereida Barud, Hernane [UNESP] Thomas, Sabu Pothen, Laly A. |
author_role |
author |
author2 |
Pillai, Prasanth K. S. Faria, Marisa Cordeiro, Nereida Barud, Hernane [UNESP] Thomas, Sabu Pothen, Laly A. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Mahatma Gandhi University Mar Thoma College C.M.S. College University of Saskatchewan University of Madeira University of Porto Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Thomas, Merin Sara Pillai, Prasanth K. S. Faria, Marisa Cordeiro, Nereida Barud, Hernane [UNESP] Thomas, Sabu Pothen, Laly A. |
description |
Fabricating novel materials for biomedical applications mostly require the use of biodegradable materials. In this work biodegradable materials like polylactic acid (PLA) and chitosan (CHS) were used for designing electrospun mats. This work reports the physical and chemical characterization of the PLA–CHS composite, prepared by the electrospinning technique using a mixed solvent system. The addition of chitosan into PLA, offered decrease in fiber diameter in the composites with uniformity in the distribution of fibers with an optimum at 0.4wt% CHS. The fiber formation and the reduction in fiber diameter were confirmed by the SEM micrograph. The inverse gas chromatography and contact angle measurements supported the increase of hydrophobicity of the composite membrane with increase of filler concentration. The weak interaction between PLA and chitosan was confirmed by Fourier transform infrared spectroscopy and thermal analysis. The stability of the composite was established by zeta potential measurements. Cytotoxicity studies of the membranes were also carried out and found that up to 0.6% CHS the composite material was noncytotoxic. The current findings are very important for the design and development of new materials based on polylactic acid-chitosan composites for environmental and biomedical applications. [Figure not available: see fulltext.]. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:54:59Z 2018-12-11T16:54:59Z 2018-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10856-018-6146-1 Journal of Materials Science: Materials in Medicine, v. 29, n. 9, 2018. 1573-4838 0957-4530 http://hdl.handle.net/11449/171349 10.1007/s10856-018-6146-1 2-s2.0-85051740940 2-s2.0-85051740940.pdf |
url |
http://dx.doi.org/10.1007/s10856-018-6146-1 http://hdl.handle.net/11449/171349 |
identifier_str_mv |
Journal of Materials Science: Materials in Medicine, v. 29, n. 9, 2018. 1573-4838 0957-4530 10.1007/s10856-018-6146-1 2-s2.0-85051740940 2-s2.0-85051740940.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Materials Science: Materials in Medicine 0,647 0,647 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129152590544896 |