Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos

Detalhes bibliográficos
Autor(a) principal: Pereira, Danyella Silva
Data de Publicação: 2013
Outros Autores: Koike, Bruna Del Vechio, Ribeiro, Amanda de Oliveira [UNESP], Umemura, Guilherme Silva, Tufik, Sergio, Neto, Mario Pedrazzoli
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf
http://hdl.handle.net/11449/76243
Resumo: HIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis.
id UNSP_a73b5fe9791abac6046e68b075f4a5df
oai_identifier_str oai:repositorio.unesp.br:11449/76243
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianosScreening for polymorphisms in the HIOMT gene and associations with circadian phenotypesCircadian rhythmGenetics behavorialMelatoninPolymorphism geneticHIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis.Department of Psychobiology Universidade Federal de São Paulo, São PauloDepartment of Genetics Universidade Estadual de São Paulo, BotucatuSchool of Arts, Science and Humanities Universidade de São Paulo, São PauloDepartment of Genetics Universidade Estadual de São Paulo, BotucatuUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Pereira, Danyella SilvaKoike, Bruna Del VechioRibeiro, Amanda de Oliveira [UNESP]Umemura, Guilherme SilvaTufik, SergioNeto, Mario Pedrazzoli2014-05-27T11:30:08Z2014-05-27T11:30:08Z2013-08-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article66-71application/pdfhttp://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdfSleep Science, v. 6, n. 2, p. 66-71, 2013.1984-06591984-0063http://hdl.handle.net/11449/762432-s2.0-848810509642-s2.0-84881050964.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporSleep Science0,5700,570info:eu-repo/semantics/openAccess2023-11-12T06:10:10Zoai:repositorio.unesp.br:11449/76243Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:26:35.287162Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
Screening for polymorphisms in the HIOMT gene and associations with circadian phenotypes
title Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
spellingShingle Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
Pereira, Danyella Silva
Circadian rhythm
Genetics behavorial
Melatonin
Polymorphism genetic
title_short Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
title_full Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
title_fullStr Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
title_full_unstemmed Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
title_sort Rastreamento de polimorfsmos no gene HIOMT e associações com os fenótipos circadianos
author Pereira, Danyella Silva
author_facet Pereira, Danyella Silva
Koike, Bruna Del Vechio
Ribeiro, Amanda de Oliveira [UNESP]
Umemura, Guilherme Silva
Tufik, Sergio
Neto, Mario Pedrazzoli
author_role author
author2 Koike, Bruna Del Vechio
Ribeiro, Amanda de Oliveira [UNESP]
Umemura, Guilherme Silva
Tufik, Sergio
Neto, Mario Pedrazzoli
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Pereira, Danyella Silva
Koike, Bruna Del Vechio
Ribeiro, Amanda de Oliveira [UNESP]
Umemura, Guilherme Silva
Tufik, Sergio
Neto, Mario Pedrazzoli
dc.subject.por.fl_str_mv Circadian rhythm
Genetics behavorial
Melatonin
Polymorphism genetic
topic Circadian rhythm
Genetics behavorial
Melatonin
Polymorphism genetic
description HIOMT is a gene that encodes hydroxyindole-O-methyltransfe-rase, the final enzyme in the melatonin synthesis pathway. As the timing of melatonin synthesis is different for morning and evening people, it is possible that polymorphisms in genes coding for the enzymes which participate in melatonin synthesis can influence this hormone synthesis and release patterns that may result in different circadian outputs. The aim of this study was to search for polymorphisms in the HIOMT gene and to verify possible associations between genetic variations in this gene and circadian phenotypes in a Brazilian population sample. Among the 44 extreme morning and the 48 extreme evening people, ten polymorphisms were found, being two of them not described so far. Haploview analyses showed linkage disequilibrium between pairs of polymorphisms in the promoter B region. Also, the haplotype AG (rs4446909, rs5989681) is associated with evening preference. The analysis of these data indicates that polymorphisms in the HIOMT gene exhibit a possible trend to influence circadian phenotypes in this Brazilian population sample, possibly affecting the rate and/or level of melatonin synthesis.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-08
2014-05-27T11:30:08Z
2014-05-27T11:30:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf
Sleep Science, v. 6, n. 2, p. 66-71, 2013.
1984-0659
1984-0063
http://hdl.handle.net/11449/76243
2-s2.0-84881050964
2-s2.0-84881050964.pdf
url http://www.sleepscience.com.br/pdf/articles/vol6/SleepScience_vol6_Issue02_art06.pdf
http://hdl.handle.net/11449/76243
identifier_str_mv Sleep Science, v. 6, n. 2, p. 66-71, 2013.
1984-0659
1984-0063
2-s2.0-84881050964
2-s2.0-84881050964.pdf
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Sleep Science
0,570
0,570
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 66-71
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128812920078336

Registros relacionados