Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11356-019-04536-0 http://hdl.handle.net/11449/190119 |
Resumo: | The advent of biotechnology provided the synthesis of nanoproducts with diverse applications in the field of medicine, agriculture, food, among others. However, the toxicity of many nanoparticles (NP) currently used, which can penetrate natural systems and impact organisms, is not known. Thus, in this study, we evaluated whether the short exposure (5 days) to low concentrations of chitosan-coated zein nanoparticles (ZNP-CS) (0.2 ng/kg, 40 ng/kg, and 400.00 ng/kg) was capable of causing behavioral alterations compatible with cognitive deficit, as well as anxiety and depression-like behavior in Swiss mice. However, we observed an anxiogenic effect in the animals exposed to the highest ZNP-CS concentration (400.00 ng/kg), without locomotor alterations suggestive of sedation or hyperactivity in the elevated plus maze (EPM) test. We also observed that the ZNP-CS caused depressive-like behavior, indicated by the longer immobile time in the tail suspension test and the animals exposed to ZNP-CS presented deficit in recognition of the new object, not related to locomotor alteration in this test. To the best of our knowledge, this is the first report of the neurotoxicity of ZNP in a mammal animal model, contributing to the biological safety assessment of these nanocomposites. |
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Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticlesEngineered nanomaterialsEnvironmental toxicologyMammalianNeurotoxicityThe advent of biotechnology provided the synthesis of nanoproducts with diverse applications in the field of medicine, agriculture, food, among others. However, the toxicity of many nanoparticles (NP) currently used, which can penetrate natural systems and impact organisms, is not known. Thus, in this study, we evaluated whether the short exposure (5 days) to low concentrations of chitosan-coated zein nanoparticles (ZNP-CS) (0.2 ng/kg, 40 ng/kg, and 400.00 ng/kg) was capable of causing behavioral alterations compatible with cognitive deficit, as well as anxiety and depression-like behavior in Swiss mice. However, we observed an anxiogenic effect in the animals exposed to the highest ZNP-CS concentration (400.00 ng/kg), without locomotor alterations suggestive of sedation or hyperactivity in the elevated plus maze (EPM) test. We also observed that the ZNP-CS caused depressive-like behavior, indicated by the longer immobile time in the tail suspension test and the animals exposed to ZNP-CS presented deficit in recognition of the new object, not related to locomotor alteration in this test. To the best of our knowledge, this is the first report of the neurotoxicity of ZNP in a mammal animal model, contributing to the biological safety assessment of these nanocomposites.Post-graduation Program in Cerrado Natural Resource Conservation and Biological Research Laboratory Instituto Federal Goiano–Urutaí CampusPost-graduation Program in Biotechnology and Biodiversity Universidade Federal de GoiásItaquera Campus São Paulo Brazil UniversityFaculty of Medicine São Leopoldo MandicInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP)Laboratório de Pesquisas Biológicas Instituto Federal Goiano–Campus Urutaí, Rodovia Geraldo Silva Nascimento, 2,5 km, Zona RuralInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP)Instituto Federal Goiano–Urutaí CampusUniversidade Federal de Goiás (UFG)Brazil UniversityFaculty of Medicine São Leopoldo MandicUniversidade Estadual Paulista (Unesp)Instituto Federal Goiano–Campus UrutaíLima, Vinícius SilvaGuimarães, Abraão Tiago Batistada Costa Araújo, Amanda PereiraEstrela, Fernanda Nevesda Silva, Ives Charliede Melo, Nathalie Ferreira SilvaFraceto, Leonardo Fernandes [UNESP]Malafaia, Guilherme2019-10-06T17:02:56Z2019-10-06T17:02:56Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10641-10650http://dx.doi.org/10.1007/s11356-019-04536-0Environmental Science and Pollution Research, v. 26, n. 11, p. 10641-10650, 2019.1614-74990944-1344http://hdl.handle.net/11449/19011910.1007/s11356-019-04536-02-s2.0-85061606635Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Science and Pollution Researchinfo:eu-repo/semantics/openAccess2021-10-23T19:02:02Zoai:repositorio.unesp.br:11449/190119Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:59:56.064156Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
title |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
spellingShingle |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles Lima, Vinícius Silva Engineered nanomaterials Environmental toxicology Mammalian Neurotoxicity |
title_short |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
title_full |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
title_fullStr |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
title_full_unstemmed |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
title_sort |
Depression, anxiety-like behavior, and memory impairment in mice exposed to chitosan-coated zein nanoparticles |
author |
Lima, Vinícius Silva |
author_facet |
Lima, Vinícius Silva Guimarães, Abraão Tiago Batista da Costa Araújo, Amanda Pereira Estrela, Fernanda Neves da Silva, Ives Charlie de Melo, Nathalie Ferreira Silva Fraceto, Leonardo Fernandes [UNESP] Malafaia, Guilherme |
author_role |
author |
author2 |
Guimarães, Abraão Tiago Batista da Costa Araújo, Amanda Pereira Estrela, Fernanda Neves da Silva, Ives Charlie de Melo, Nathalie Ferreira Silva Fraceto, Leonardo Fernandes [UNESP] Malafaia, Guilherme |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Instituto Federal Goiano–Urutaí Campus Universidade Federal de Goiás (UFG) Brazil University Faculty of Medicine São Leopoldo Mandic Universidade Estadual Paulista (Unesp) Instituto Federal Goiano–Campus Urutaí |
dc.contributor.author.fl_str_mv |
Lima, Vinícius Silva Guimarães, Abraão Tiago Batista da Costa Araújo, Amanda Pereira Estrela, Fernanda Neves da Silva, Ives Charlie de Melo, Nathalie Ferreira Silva Fraceto, Leonardo Fernandes [UNESP] Malafaia, Guilherme |
dc.subject.por.fl_str_mv |
Engineered nanomaterials Environmental toxicology Mammalian Neurotoxicity |
topic |
Engineered nanomaterials Environmental toxicology Mammalian Neurotoxicity |
description |
The advent of biotechnology provided the synthesis of nanoproducts with diverse applications in the field of medicine, agriculture, food, among others. However, the toxicity of many nanoparticles (NP) currently used, which can penetrate natural systems and impact organisms, is not known. Thus, in this study, we evaluated whether the short exposure (5 days) to low concentrations of chitosan-coated zein nanoparticles (ZNP-CS) (0.2 ng/kg, 40 ng/kg, and 400.00 ng/kg) was capable of causing behavioral alterations compatible with cognitive deficit, as well as anxiety and depression-like behavior in Swiss mice. However, we observed an anxiogenic effect in the animals exposed to the highest ZNP-CS concentration (400.00 ng/kg), without locomotor alterations suggestive of sedation or hyperactivity in the elevated plus maze (EPM) test. We also observed that the ZNP-CS caused depressive-like behavior, indicated by the longer immobile time in the tail suspension test and the animals exposed to ZNP-CS presented deficit in recognition of the new object, not related to locomotor alteration in this test. To the best of our knowledge, this is the first report of the neurotoxicity of ZNP in a mammal animal model, contributing to the biological safety assessment of these nanocomposites. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:02:56Z 2019-10-06T17:02:56Z 2019-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11356-019-04536-0 Environmental Science and Pollution Research, v. 26, n. 11, p. 10641-10650, 2019. 1614-7499 0944-1344 http://hdl.handle.net/11449/190119 10.1007/s11356-019-04536-0 2-s2.0-85061606635 |
url |
http://dx.doi.org/10.1007/s11356-019-04536-0 http://hdl.handle.net/11449/190119 |
identifier_str_mv |
Environmental Science and Pollution Research, v. 26, n. 11, p. 10641-10650, 2019. 1614-7499 0944-1344 10.1007/s11356-019-04536-0 2-s2.0-85061606635 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Science and Pollution Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
10641-10650 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128733681287168 |