Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.msec.2020.111149 http://hdl.handle.net/11449/201875 |
Resumo: | Organic-inorganic hybrid coatings deposited on different types of metallic alloys have shown outstanding anticorrosive performance. The incorporation of osteoconductive additives such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) into organic-inorganic hybrid coatings is promising to improve the osseointegration and corrosion resistance of Ti6Al4V alloys, which are the most widely used metallic orthopedic and dental implant materials today. Therefore, this study evaluated the capability of poly(methyl methacrylate) (PMMA)-TiO2 and PMMA-ZrO2 hybrid coatings modified with HA and β-TCP to act as bioactive and corrosion protection coatings for Ti6Al4V alloys. In terms of cell growth and mineralization, osteoblast viability, Ca+2 deposition and alkaline phosphatase assays revealed a significant improvement for the HA and β-TCP modified coatings, compared to the bare alloy. This can be explained by an increase in nanoscale roughness and associated higher surface free energy, which lead to enhanced protein adsorption to promote osteoblast attachment and functions on the coatings. The effect of HA and β-TCP additives on the anticorrosive efficiency was studied by electrochemical impedance spectroscopy (EIS) in a simulated body fluid (SBF) solution. The coatings presented a low-frequency impedance modulus of up to 430 GΩ cm2, 5 decades higher than the bare Ti6Al4V alloy. These findings provide clear evidence of the beneficial role of HA and β-TCP modified hybrid coatings, improving both the biocompatibility and corrosion resistance of the Ti6Al4V alloy. |
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Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implantsBioactive coatingCorrosion protectionNanocomposite coatingOrganic-inorganic hybridTi6Al4V alloyOrganic-inorganic hybrid coatings deposited on different types of metallic alloys have shown outstanding anticorrosive performance. The incorporation of osteoconductive additives such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) into organic-inorganic hybrid coatings is promising to improve the osseointegration and corrosion resistance of Ti6Al4V alloys, which are the most widely used metallic orthopedic and dental implant materials today. Therefore, this study evaluated the capability of poly(methyl methacrylate) (PMMA)-TiO2 and PMMA-ZrO2 hybrid coatings modified with HA and β-TCP to act as bioactive and corrosion protection coatings for Ti6Al4V alloys. In terms of cell growth and mineralization, osteoblast viability, Ca+2 deposition and alkaline phosphatase assays revealed a significant improvement for the HA and β-TCP modified coatings, compared to the bare alloy. This can be explained by an increase in nanoscale roughness and associated higher surface free energy, which lead to enhanced protein adsorption to promote osteoblast attachment and functions on the coatings. The effect of HA and β-TCP additives on the anticorrosive efficiency was studied by electrochemical impedance spectroscopy (EIS) in a simulated body fluid (SBF) solution. The coatings presented a low-frequency impedance modulus of up to 430 GΩ cm2, 5 decades higher than the bare Ti6Al4V alloy. These findings provide clear evidence of the beneficial role of HA and β-TCP modified hybrid coatings, improving both the biocompatibility and corrosion resistance of the Ti6Al4V alloy.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State University (UNESP) Institute of ChemistryDepartment of Chemical Engineering Northeastern UniversityFederal University of Piauí (UFPI) Interdisciplinary Laboratory for Advanced Materials (LIMAV) Department of Materials EngineeringSão Paulo State University (UNESP) Institute of ChemistryCAPES: 001FAPESP: 2015/09342-7FAPESP: 2015/11907-2FAPESP: 2017/02899-1FAPESP: 2017/14061-2CNPq: 303752/2017-3CNPq: 307905/2018-7CNPq: 421081/2016-3CNPq: 424133/2016-4Universidade Estadual Paulista (Unesp)Northeastern UniversityInterdisciplinary Laboratory for Advanced Materials (LIMAV)Harb, Samarah V. [UNESP]Bassous, Nicole J.de Souza, Thiago A.C. [UNESP]Trentin, Andressa [UNESP]Pulcinelli, Sandra H. [UNESP]Santilli, Celso V. [UNESP]Webster, Thomas J.Lobo, Anderson O.Hammer, Peter [UNESP]2020-12-12T02:44:08Z2020-12-12T02:44:08Z2020-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.msec.2020.111149Materials Science and Engineering C, v. 116.1873-01910928-4931http://hdl.handle.net/11449/20187510.1016/j.msec.2020.1111492-s2.0-8508644816555842986818708650000-0002-8356-8093Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Science and Engineering Cinfo:eu-repo/semantics/openAccess2021-10-23T02:05:54Zoai:repositorio.unesp.br:11449/201875Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:16:30.605646Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
title |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
spellingShingle |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants Harb, Samarah V. [UNESP] Bioactive coating Corrosion protection Nanocomposite coating Organic-inorganic hybrid Ti6Al4V alloy |
title_short |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
title_full |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
title_fullStr |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
title_full_unstemmed |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
title_sort |
Hydroxyapatite and β-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants |
author |
Harb, Samarah V. [UNESP] |
author_facet |
Harb, Samarah V. [UNESP] Bassous, Nicole J. de Souza, Thiago A.C. [UNESP] Trentin, Andressa [UNESP] Pulcinelli, Sandra H. [UNESP] Santilli, Celso V. [UNESP] Webster, Thomas J. Lobo, Anderson O. Hammer, Peter [UNESP] |
author_role |
author |
author2 |
Bassous, Nicole J. de Souza, Thiago A.C. [UNESP] Trentin, Andressa [UNESP] Pulcinelli, Sandra H. [UNESP] Santilli, Celso V. [UNESP] Webster, Thomas J. Lobo, Anderson O. Hammer, Peter [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Northeastern University Interdisciplinary Laboratory for Advanced Materials (LIMAV) |
dc.contributor.author.fl_str_mv |
Harb, Samarah V. [UNESP] Bassous, Nicole J. de Souza, Thiago A.C. [UNESP] Trentin, Andressa [UNESP] Pulcinelli, Sandra H. [UNESP] Santilli, Celso V. [UNESP] Webster, Thomas J. Lobo, Anderson O. Hammer, Peter [UNESP] |
dc.subject.por.fl_str_mv |
Bioactive coating Corrosion protection Nanocomposite coating Organic-inorganic hybrid Ti6Al4V alloy |
topic |
Bioactive coating Corrosion protection Nanocomposite coating Organic-inorganic hybrid Ti6Al4V alloy |
description |
Organic-inorganic hybrid coatings deposited on different types of metallic alloys have shown outstanding anticorrosive performance. The incorporation of osteoconductive additives such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) into organic-inorganic hybrid coatings is promising to improve the osseointegration and corrosion resistance of Ti6Al4V alloys, which are the most widely used metallic orthopedic and dental implant materials today. Therefore, this study evaluated the capability of poly(methyl methacrylate) (PMMA)-TiO2 and PMMA-ZrO2 hybrid coatings modified with HA and β-TCP to act as bioactive and corrosion protection coatings for Ti6Al4V alloys. In terms of cell growth and mineralization, osteoblast viability, Ca+2 deposition and alkaline phosphatase assays revealed a significant improvement for the HA and β-TCP modified coatings, compared to the bare alloy. This can be explained by an increase in nanoscale roughness and associated higher surface free energy, which lead to enhanced protein adsorption to promote osteoblast attachment and functions on the coatings. The effect of HA and β-TCP additives on the anticorrosive efficiency was studied by electrochemical impedance spectroscopy (EIS) in a simulated body fluid (SBF) solution. The coatings presented a low-frequency impedance modulus of up to 430 GΩ cm2, 5 decades higher than the bare Ti6Al4V alloy. These findings provide clear evidence of the beneficial role of HA and β-TCP modified hybrid coatings, improving both the biocompatibility and corrosion resistance of the Ti6Al4V alloy. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:44:08Z 2020-12-12T02:44:08Z 2020-11-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.msec.2020.111149 Materials Science and Engineering C, v. 116. 1873-0191 0928-4931 http://hdl.handle.net/11449/201875 10.1016/j.msec.2020.111149 2-s2.0-85086448165 5584298681870865 0000-0002-8356-8093 |
url |
http://dx.doi.org/10.1016/j.msec.2020.111149 http://hdl.handle.net/11449/201875 |
identifier_str_mv |
Materials Science and Engineering C, v. 116. 1873-0191 0928-4931 10.1016/j.msec.2020.111149 2-s2.0-85086448165 5584298681870865 0000-0002-8356-8093 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Science and Engineering C |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129044457193472 |