Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women

Detalhes bibliográficos
Autor(a) principal: Mayrink, Jussara
Data de Publicação: 2019
Outros Autores: Souza, Renato T., Feitosa, Francisco E., Rocha Filho, Edilberto A., Leite, Débora F., Vettorazzi, Janete, Calderon, Iracema M. [UNESP], Costa, Maria L., Kenny, Louise, Baker, Philip, Cecatti, Jose G., Parpinelli, Mary A., Fernandes, Karayna G., Guida, José P., Santana, Danielly, Galvao, Rafael B. F., Cassettari, Bianca F., Pfitscher, Lucia, De Feitosa, Daisy Lucena, De Melo Ferreira Júnior, Elias, Anacleto, Danilo, Zotareli, Vilma, Silva, Marcia Alice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/s12884-019-2580-4
http://hdl.handle.net/11449/199750
Resumo: Background: Prediction of preeclampsia is a challenge to overcome. The vast majority of prospective studies in large general obstetric populations have failed in the purpose of obtain a useful and effective model of prediction, sometimes based on complex tools unavaible in areas where the incidence of preeclampsia is the highest. The goal of this study was to assess mean arterial blood pressure (MAP) levels at 19-21, 27-29 and 37-39 weeks of gestation and performance of screening by MAP for the prediction of preeclampsia in a Brazilian cohort of healthy nulliparous pregnant women. Methods: This was a cohort approach to a secondary analysis of the Preterm SAMBA study. Mean arterial blood pressure was evaluated at three different time periods during pregnancy. Groups with early-onset preeclampsia, late-onset preeclampsia and normotension were compared. Increments in mean arterial blood pressure between 20 and 27 weeks and 20 and 37 weeks of gestation were also calculated for the three groups studied. The accuracy of mean arterial blood pressure in the prediction of preeclampsia was determined by ROC curves. Results: Of the 1373 participants enrolled, complete data were available for 1165. The incidence of preeclampsia was 7.5%. Women with early-onset preeclampsia had higher mean arterial blood pressure levels at 20 weeks of gestation, compared to the normotensive group. Women with late-onset preeclampsia had higher mean arterial blood pressure levels at 37 weeks of gestation, than the normotensive groups and higher increases in this marker between 20 and 37 weeks of gestation. Based on ROC curves, the predictive performance of mean arterial blood pressure was higher at 37 weeks of gestation, with an area under the curve of 0.771. Conclusion: As an isolated marker for the prediction of preeclampsia, the performance of mean arterial blood pressure was low in a healthy nulliparous pregnant women group. Considering that early-onset preeclampsia cases had higher mean arterial blood pressure levels at 20 weeks of gestation, future studies with larger cohorts that combine multiple markers are needed for the development of a preeclampsia prediction model.
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spelling Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant womenBlood pressureHypertensionPreeclampsiaPrenatal screeningSecond trimesterThird trimesterBackground: Prediction of preeclampsia is a challenge to overcome. The vast majority of prospective studies in large general obstetric populations have failed in the purpose of obtain a useful and effective model of prediction, sometimes based on complex tools unavaible in areas where the incidence of preeclampsia is the highest. The goal of this study was to assess mean arterial blood pressure (MAP) levels at 19-21, 27-29 and 37-39 weeks of gestation and performance of screening by MAP for the prediction of preeclampsia in a Brazilian cohort of healthy nulliparous pregnant women. Methods: This was a cohort approach to a secondary analysis of the Preterm SAMBA study. Mean arterial blood pressure was evaluated at three different time periods during pregnancy. Groups with early-onset preeclampsia, late-onset preeclampsia and normotension were compared. Increments in mean arterial blood pressure between 20 and 27 weeks and 20 and 37 weeks of gestation were also calculated for the three groups studied. The accuracy of mean arterial blood pressure in the prediction of preeclampsia was determined by ROC curves. Results: Of the 1373 participants enrolled, complete data were available for 1165. The incidence of preeclampsia was 7.5%. Women with early-onset preeclampsia had higher mean arterial blood pressure levels at 20 weeks of gestation, compared to the normotensive group. Women with late-onset preeclampsia had higher mean arterial blood pressure levels at 37 weeks of gestation, than the normotensive groups and higher increases in this marker between 20 and 37 weeks of gestation. Based on ROC curves, the predictive performance of mean arterial blood pressure was higher at 37 weeks of gestation, with an area under the curve of 0.771. Conclusion: As an isolated marker for the prediction of preeclampsia, the performance of mean arterial blood pressure was low in a healthy nulliparous pregnant women group. Considering that early-onset preeclampsia cases had higher mean arterial blood pressure levels at 20 weeks of gestation, future studies with larger cohorts that combine multiple markers are needed for the development of a preeclampsia prediction model.Department of Obstetrics and Gynecology University of Campinas (UNICAMP) School of Medical Sciences, Rua Alexander Fleming, 101MEAC Maternity Hospital Federal University of CearáDepartment of Maternal and Child Health Maternity Hospital Federal University of PernambucoDepartment of Obstetrics and Gynecology Maternity Hospital Federal University of RSDepartment of Obstetrics and Gynecology Botucatu Medical School UnespCollege of Life Sciences University of LeicesterFaculty of Health and Life Sciences Department of Women's and Children's Health Institute of Translational Medicine University of LiverpoolDepartment of Obstetrics and Gynecology Botucatu Medical School UnespUniversidade Estadual de Campinas (UNICAMP)Federal University of CearáUniversidade Federal de Pernambuco (UFPE)Federal University of RSUniversidade Estadual Paulista (Unesp)University of LeicesterUniversity of LiverpoolMayrink, JussaraSouza, Renato T.Feitosa, Francisco E.Rocha Filho, Edilberto A.Leite, Débora F.Vettorazzi, JaneteCalderon, Iracema M. [UNESP]Costa, Maria L.Kenny, LouiseBaker, PhilipCecatti, Jose G.Parpinelli, Mary A.Fernandes, Karayna G.Guida, José P.Santana, DaniellyGalvao, Rafael B. F.Cassettari, Bianca F.Pfitscher, LuciaDe Feitosa, Daisy LucenaDe Melo Ferreira Júnior, EliasAnacleto, DaniloZotareli, VilmaSilva, Marcia Alice2020-12-12T01:48:20Z2020-12-12T01:48:20Z2019-12-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12884-019-2580-4BMC Pregnancy and Childbirth, v. 19, n. 1, 2019.1471-2393http://hdl.handle.net/11449/19975010.1186/s12884-019-2580-42-s2.0-85075929304Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Pregnancy and Childbirthinfo:eu-repo/semantics/openAccess2024-08-16T14:07:07Zoai:repositorio.unesp.br:11449/199750Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
title Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
spellingShingle Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
Mayrink, Jussara
Blood pressure
Hypertension
Preeclampsia
Prenatal screening
Second trimester
Third trimester
title_short Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
title_full Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
title_fullStr Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
title_full_unstemmed Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
title_sort Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women
author Mayrink, Jussara
author_facet Mayrink, Jussara
Souza, Renato T.
Feitosa, Francisco E.
Rocha Filho, Edilberto A.
Leite, Débora F.
Vettorazzi, Janete
Calderon, Iracema M. [UNESP]
Costa, Maria L.
Kenny, Louise
Baker, Philip
Cecatti, Jose G.
Parpinelli, Mary A.
Fernandes, Karayna G.
Guida, José P.
Santana, Danielly
Galvao, Rafael B. F.
Cassettari, Bianca F.
Pfitscher, Lucia
De Feitosa, Daisy Lucena
De Melo Ferreira Júnior, Elias
Anacleto, Danilo
Zotareli, Vilma
Silva, Marcia Alice
author_role author
author2 Souza, Renato T.
Feitosa, Francisco E.
Rocha Filho, Edilberto A.
Leite, Débora F.
Vettorazzi, Janete
Calderon, Iracema M. [UNESP]
Costa, Maria L.
Kenny, Louise
Baker, Philip
Cecatti, Jose G.
Parpinelli, Mary A.
Fernandes, Karayna G.
Guida, José P.
Santana, Danielly
Galvao, Rafael B. F.
Cassettari, Bianca F.
Pfitscher, Lucia
De Feitosa, Daisy Lucena
De Melo Ferreira Júnior, Elias
Anacleto, Danilo
Zotareli, Vilma
Silva, Marcia Alice
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Federal University of Ceará
Universidade Federal de Pernambuco (UFPE)
Federal University of RS
Universidade Estadual Paulista (Unesp)
University of Leicester
University of Liverpool
dc.contributor.author.fl_str_mv Mayrink, Jussara
Souza, Renato T.
Feitosa, Francisco E.
Rocha Filho, Edilberto A.
Leite, Débora F.
Vettorazzi, Janete
Calderon, Iracema M. [UNESP]
Costa, Maria L.
Kenny, Louise
Baker, Philip
Cecatti, Jose G.
Parpinelli, Mary A.
Fernandes, Karayna G.
Guida, José P.
Santana, Danielly
Galvao, Rafael B. F.
Cassettari, Bianca F.
Pfitscher, Lucia
De Feitosa, Daisy Lucena
De Melo Ferreira Júnior, Elias
Anacleto, Danilo
Zotareli, Vilma
Silva, Marcia Alice
dc.subject.por.fl_str_mv Blood pressure
Hypertension
Preeclampsia
Prenatal screening
Second trimester
Third trimester
topic Blood pressure
Hypertension
Preeclampsia
Prenatal screening
Second trimester
Third trimester
description Background: Prediction of preeclampsia is a challenge to overcome. The vast majority of prospective studies in large general obstetric populations have failed in the purpose of obtain a useful and effective model of prediction, sometimes based on complex tools unavaible in areas where the incidence of preeclampsia is the highest. The goal of this study was to assess mean arterial blood pressure (MAP) levels at 19-21, 27-29 and 37-39 weeks of gestation and performance of screening by MAP for the prediction of preeclampsia in a Brazilian cohort of healthy nulliparous pregnant women. Methods: This was a cohort approach to a secondary analysis of the Preterm SAMBA study. Mean arterial blood pressure was evaluated at three different time periods during pregnancy. Groups with early-onset preeclampsia, late-onset preeclampsia and normotension were compared. Increments in mean arterial blood pressure between 20 and 27 weeks and 20 and 37 weeks of gestation were also calculated for the three groups studied. The accuracy of mean arterial blood pressure in the prediction of preeclampsia was determined by ROC curves. Results: Of the 1373 participants enrolled, complete data were available for 1165. The incidence of preeclampsia was 7.5%. Women with early-onset preeclampsia had higher mean arterial blood pressure levels at 20 weeks of gestation, compared to the normotensive group. Women with late-onset preeclampsia had higher mean arterial blood pressure levels at 37 weeks of gestation, than the normotensive groups and higher increases in this marker between 20 and 37 weeks of gestation. Based on ROC curves, the predictive performance of mean arterial blood pressure was higher at 37 weeks of gestation, with an area under the curve of 0.771. Conclusion: As an isolated marker for the prediction of preeclampsia, the performance of mean arterial blood pressure was low in a healthy nulliparous pregnant women group. Considering that early-onset preeclampsia cases had higher mean arterial blood pressure levels at 20 weeks of gestation, future studies with larger cohorts that combine multiple markers are needed for the development of a preeclampsia prediction model.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-03
2020-12-12T01:48:20Z
2020-12-12T01:48:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s12884-019-2580-4
BMC Pregnancy and Childbirth, v. 19, n. 1, 2019.
1471-2393
http://hdl.handle.net/11449/199750
10.1186/s12884-019-2580-4
2-s2.0-85075929304
url http://dx.doi.org/10.1186/s12884-019-2580-4
http://hdl.handle.net/11449/199750
identifier_str_mv BMC Pregnancy and Childbirth, v. 19, n. 1, 2019.
1471-2393
10.1186/s12884-019-2580-4
2-s2.0-85075929304
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Pregnancy and Childbirth
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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