Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/204312 |
Resumo: | Background. Habituation of postural response to perturbations is impaired in people with Parkinson’s disease (PD) due to deficits in cortico-basal pathways. Although transcranial direct current stimulation (tDCS) modulate cortico-basal networks, it remains unclear if it can benefit postural control in PD. Objective. To analyze the effect of different intensities of anodal tDCS on postural responses and prefrontal cortex (PFC) activity during the habituation to the external perturbation in patients with PD (n = 24). Methods. Anodal tDCS was applied over the primary motor cortex (M1) with 1 mA, 2 mA, and sham stimulation in 3 different sessions (~2 weeks apart) during 20 minutes immediately before the postural assessment. External perturbation (7 trials) was applied by a support base posterior translation (20 cm/s and 5 cm). Primary outcome measures included lower limb electromyography and center of pressure parameters. Measures of PFC activity are reported as exploratory outcomes. Analyses of variance (Stimulation Condition × Trial) were performed. Results. Habituation of perturbation was evidenced independent of the stimulation conditions. Both active stimulation intensities had shorter recovery time and a trend for lower cortical activity in the stimulated hemisphere when compared to sham condition. Shorter onset latency of the medial gastrocnemius as well as lower cortical activity in the nonstimulated hemisphere were only observed after 2 mA concerning the sham condition. Conclusions. tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA. However, tDCS seems to be inefficient in modifying the habituation of perturbation. |
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Repositório Institucional da UNESP |
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2946 |
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Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s diseasePostural balanceMovement disordersBrain stimulationElectromyographyNervous system degenerationInfrared spectroscopyNeural stimulationBackground. Habituation of postural response to perturbations is impaired in people with Parkinson’s disease (PD) due to deficits in cortico-basal pathways. Although transcranial direct current stimulation (tDCS) modulate cortico-basal networks, it remains unclear if it can benefit postural control in PD. Objective. To analyze the effect of different intensities of anodal tDCS on postural responses and prefrontal cortex (PFC) activity during the habituation to the external perturbation in patients with PD (n = 24). Methods. Anodal tDCS was applied over the primary motor cortex (M1) with 1 mA, 2 mA, and sham stimulation in 3 different sessions (~2 weeks apart) during 20 minutes immediately before the postural assessment. External perturbation (7 trials) was applied by a support base posterior translation (20 cm/s and 5 cm). Primary outcome measures included lower limb electromyography and center of pressure parameters. Measures of PFC activity are reported as exploratory outcomes. Analyses of variance (Stimulation Condition × Trial) were performed. Results. Habituation of perturbation was evidenced independent of the stimulation conditions. Both active stimulation intensities had shorter recovery time and a trend for lower cortical activity in the stimulated hemisphere when compared to sham condition. Shorter onset latency of the medial gastrocnemius as well as lower cortical activity in the nonstimulated hemisphere were only observed after 2 mA concerning the sham condition. Conclusions. tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA. However, tDCS seems to be inefficient in modifying the habituation of perturbation.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)PostprintSão Paulo State University (UNESP), Institute of Biosciences, Graduate Program in Movement Sciences, Posture and Gait Studies Laboratory (LEPLO), Rio Claro, São Paulo, BrazilOregon Health & Science University, Portland, OR, USAFAPESP: 2018/07385-9FAPESP: 2016/21499-1FAPESP: 2014/22308-0CNPq: 142057/2017-7CNPq: 309045/2017-7CAPES: 001SAGE PublicationsUniversidade Estadual Paulista (Unesp)Beretta, Victor Spiandor [UNESP]Vitório, Rodrigo [UNESP]Nóbrega-Sousa, Priscila [UNESP]Conceição, Núbia Ribeiro [UNESP]Orcioli-Silva, Diego [UNESP]Pereira, Marcelo Pinto [UNESP]Gobbi, Lilian Teresa Bucken [UNESP]2021-04-08T20:36:14Z2021-04-08T20:36:14Z2020-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNeurorehabilitation and neural repair, v. 34, n. 11, p. 1009-1019, 20201545-96831552-6844http://hdl.handle.net/11449/20431210.1177/154596832096251340077001717518240338403568204710439823542389185465063097717033417451056032351695182492536883354398688352718224210000-0002-4640-77330000-0001-7128-94520000-0001-9448-01610000-0003-2213-62000000-0002-2278-80920000-0002-9442-03850000-0003-3984-3403engNeurorehabilitation and neural repairinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2023-10-09T06:09:30Zoai:repositorio.unesp.br:11449/204312Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:29:17.921158Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
title |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
spellingShingle |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease Beretta, Victor Spiandor [UNESP] Postural balance Movement disorders Brain stimulation Electromyography Nervous system degeneration Infrared spectroscopy Neural stimulation |
title_short |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
title_full |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
title_fullStr |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
title_full_unstemmed |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
title_sort |
Effect of different intensities of transcranial direct current stimulation on postural response to external perturbation in patients with Parkinson’s disease |
author |
Beretta, Victor Spiandor [UNESP] |
author_facet |
Beretta, Victor Spiandor [UNESP] Vitório, Rodrigo [UNESP] Nóbrega-Sousa, Priscila [UNESP] Conceição, Núbia Ribeiro [UNESP] Orcioli-Silva, Diego [UNESP] Pereira, Marcelo Pinto [UNESP] Gobbi, Lilian Teresa Bucken [UNESP] |
author_role |
author |
author2 |
Vitório, Rodrigo [UNESP] Nóbrega-Sousa, Priscila [UNESP] Conceição, Núbia Ribeiro [UNESP] Orcioli-Silva, Diego [UNESP] Pereira, Marcelo Pinto [UNESP] Gobbi, Lilian Teresa Bucken [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Beretta, Victor Spiandor [UNESP] Vitório, Rodrigo [UNESP] Nóbrega-Sousa, Priscila [UNESP] Conceição, Núbia Ribeiro [UNESP] Orcioli-Silva, Diego [UNESP] Pereira, Marcelo Pinto [UNESP] Gobbi, Lilian Teresa Bucken [UNESP] |
dc.subject.por.fl_str_mv |
Postural balance Movement disorders Brain stimulation Electromyography Nervous system degeneration Infrared spectroscopy Neural stimulation |
topic |
Postural balance Movement disorders Brain stimulation Electromyography Nervous system degeneration Infrared spectroscopy Neural stimulation |
description |
Background. Habituation of postural response to perturbations is impaired in people with Parkinson’s disease (PD) due to deficits in cortico-basal pathways. Although transcranial direct current stimulation (tDCS) modulate cortico-basal networks, it remains unclear if it can benefit postural control in PD. Objective. To analyze the effect of different intensities of anodal tDCS on postural responses and prefrontal cortex (PFC) activity during the habituation to the external perturbation in patients with PD (n = 24). Methods. Anodal tDCS was applied over the primary motor cortex (M1) with 1 mA, 2 mA, and sham stimulation in 3 different sessions (~2 weeks apart) during 20 minutes immediately before the postural assessment. External perturbation (7 trials) was applied by a support base posterior translation (20 cm/s and 5 cm). Primary outcome measures included lower limb electromyography and center of pressure parameters. Measures of PFC activity are reported as exploratory outcomes. Analyses of variance (Stimulation Condition × Trial) were performed. Results. Habituation of perturbation was evidenced independent of the stimulation conditions. Both active stimulation intensities had shorter recovery time and a trend for lower cortical activity in the stimulated hemisphere when compared to sham condition. Shorter onset latency of the medial gastrocnemius as well as lower cortical activity in the nonstimulated hemisphere were only observed after 2 mA concerning the sham condition. Conclusions. tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA. However, tDCS seems to be inefficient in modifying the habituation of perturbation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11 2021-04-08T20:36:14Z 2021-04-08T20:36:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Neurorehabilitation and neural repair, v. 34, n. 11, p. 1009-1019, 2020 1545-9683 1552-6844 http://hdl.handle.net/11449/204312 10.1177/1545968320962513 4007700171751824 0338403568204710 4398235423891854 6506309771703341 7451056032351695 1824925368833543 9868835271822421 0000-0002-4640-7733 0000-0001-7128-9452 0000-0001-9448-0161 0000-0003-2213-6200 0000-0002-2278-8092 0000-0002-9442-0385 0000-0003-3984-3403 |
identifier_str_mv |
Neurorehabilitation and neural repair, v. 34, n. 11, p. 1009-1019, 2020 1545-9683 1552-6844 10.1177/1545968320962513 4007700171751824 0338403568204710 4398235423891854 6506309771703341 7451056032351695 1824925368833543 9868835271822421 0000-0002-4640-7733 0000-0001-7128-9452 0000-0001-9448-0161 0000-0003-2213-6200 0000-0002-2278-8092 0000-0002-9442-0385 0000-0003-3984-3403 |
url |
http://hdl.handle.net/11449/204312 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurorehabilitation and neural repair |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
SAGE Publications |
publisher.none.fl_str_mv |
SAGE Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128366870528000 |