Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats

Detalhes bibliográficos
Autor(a) principal: Leal-Silva, Thaís
Data de Publicação: 2022
Outros Autores: Souza, Maysa Rocha [UNESP], Cruz, Larissa Lopes [UNESP], Moraes-Souza, Rafaianne Queiroz [UNESP], Paula, Verônyca Gonçalves [UNESP], Soares, Thaigra Sousa, Dela Justina, Vanessa, Giachini, Fernanda Regina, Damasceno, Débora Cristina [UNESP], Américo, Madileine Francely, Volpato, Gustavo Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/01480545.2022.2070197
http://hdl.handle.net/11449/241216
Resumo: Morinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate the effects of the M. citrifolia fruit extract on maternal performance and fetal development during pregnancy in rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0–21 with water (control group) or the aqueous extract of M. citrifolia fruit at doses of 200, 400, or 750 mg/kg, orally. During pregnancy, clinical signs of toxicity, maternal weight, feed intake, and water consumption were noted. On GD 21, the rats were anesthetized and blood was collected to evaluate various biochemical parameters. During laparotomy, reproductive performance parameters were recorded, and fetuses were weighed and the anomalies analyzed. Reduced placental efficiency and fetal growth restriction were observed in the group treated with 400 mg/kg of M. citrifolia extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration and preimplantation losses, while reducing the number of live fetuses. Furthermore, both doses (400 and 750 mg/kg) of the plant extract caused fetal anomalies. In conclusion, consumption of high doses of the M. citrifolia aqueous extrac during pregnancy leads to maternal hepatotoxicity, anti-implantation effects, intrauterine growth restriction and fetal abnormalities, indicating that the plant fruit extract can be harmful to both the mother and the fetus.
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spelling Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in ratsanti-implantationmaternal toxicityNoniratsteratogenicityMorinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate the effects of the M. citrifolia fruit extract on maternal performance and fetal development during pregnancy in rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0–21 with water (control group) or the aqueous extract of M. citrifolia fruit at doses of 200, 400, or 750 mg/kg, orally. During pregnancy, clinical signs of toxicity, maternal weight, feed intake, and water consumption were noted. On GD 21, the rats were anesthetized and blood was collected to evaluate various biochemical parameters. During laparotomy, reproductive performance parameters were recorded, and fetuses were weighed and the anomalies analyzed. Reduced placental efficiency and fetal growth restriction were observed in the group treated with 400 mg/kg of M. citrifolia extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration and preimplantation losses, while reducing the number of live fetuses. Furthermore, both doses (400 and 750 mg/kg) of the plant extract caused fetal anomalies. In conclusion, consumption of high doses of the M. citrifolia aqueous extrac during pregnancy leads to maternal hepatotoxicity, anti-implantation effects, intrauterine growth restriction and fetal abnormalities, indicating that the plant fruit extract can be harmful to both the mother and the fetus.Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT)Laboratory of Experimental Research on Gynecology and Obstetrics Graduate Program on Gynecology Obstetrics and Mastology Sao Paulo State University (UNESP)Federal University of Mato Grosso Institute of Health Sciences and HealthLaboratory of Experimental Research on Gynecology and Obstetrics Graduate Program on Gynecology Obstetrics and Mastology Sao Paulo State University (UNESP)Federal University of Mato Grosso (UFMT)Universidade Estadual Paulista (UNESP)Institute of Health Sciences and HealthLeal-Silva, ThaísSouza, Maysa Rocha [UNESP]Cruz, Larissa Lopes [UNESP]Moraes-Souza, Rafaianne Queiroz [UNESP]Paula, Verônyca Gonçalves [UNESP]Soares, Thaigra SousaDela Justina, VanessaGiachini, Fernanda ReginaDamasceno, Débora Cristina [UNESP]Américo, Madileine FrancelyVolpato, Gustavo Tadeu2023-03-01T20:52:08Z2023-03-01T20:52:08Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/01480545.2022.2070197Drug and Chemical Toxicology.1525-60140148-0545http://hdl.handle.net/11449/24121610.1080/01480545.2022.20701972-s2.0-85132674215Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDrug and Chemical Toxicologyinfo:eu-repo/semantics/openAccess2024-08-16T14:07:21Zoai:repositorio.unesp.br:11449/241216Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
title Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
spellingShingle Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
Leal-Silva, Thaís
anti-implantation
maternal toxicity
Noni
rats
teratogenicity
title_short Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
title_full Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
title_fullStr Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
title_full_unstemmed Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
title_sort Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats
author Leal-Silva, Thaís
author_facet Leal-Silva, Thaís
Souza, Maysa Rocha [UNESP]
Cruz, Larissa Lopes [UNESP]
Moraes-Souza, Rafaianne Queiroz [UNESP]
Paula, Verônyca Gonçalves [UNESP]
Soares, Thaigra Sousa
Dela Justina, Vanessa
Giachini, Fernanda Regina
Damasceno, Débora Cristina [UNESP]
Américo, Madileine Francely
Volpato, Gustavo Tadeu
author_role author
author2 Souza, Maysa Rocha [UNESP]
Cruz, Larissa Lopes [UNESP]
Moraes-Souza, Rafaianne Queiroz [UNESP]
Paula, Verônyca Gonçalves [UNESP]
Soares, Thaigra Sousa
Dela Justina, Vanessa
Giachini, Fernanda Regina
Damasceno, Débora Cristina [UNESP]
Américo, Madileine Francely
Volpato, Gustavo Tadeu
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Mato Grosso (UFMT)
Universidade Estadual Paulista (UNESP)
Institute of Health Sciences and Health
dc.contributor.author.fl_str_mv Leal-Silva, Thaís
Souza, Maysa Rocha [UNESP]
Cruz, Larissa Lopes [UNESP]
Moraes-Souza, Rafaianne Queiroz [UNESP]
Paula, Verônyca Gonçalves [UNESP]
Soares, Thaigra Sousa
Dela Justina, Vanessa
Giachini, Fernanda Regina
Damasceno, Débora Cristina [UNESP]
Américo, Madileine Francely
Volpato, Gustavo Tadeu
dc.subject.por.fl_str_mv anti-implantation
maternal toxicity
Noni
rats
teratogenicity
topic anti-implantation
maternal toxicity
Noni
rats
teratogenicity
description Morinda citrifolia L., also known as Noni, is widely used plant in folk medicine for various therapeutic purposes. However, reports on its effects during pregnancy are limited. Therefore, the objective of this study was to evaluate the effects of the M. citrifolia fruit extract on maternal performance and fetal development during pregnancy in rats. Pregnant Wistar rats (n = 12/group) were treated from gestational days (GD) 0–21 with water (control group) or the aqueous extract of M. citrifolia fruit at doses of 200, 400, or 750 mg/kg, orally. During pregnancy, clinical signs of toxicity, maternal weight, feed intake, and water consumption were noted. On GD 21, the rats were anesthetized and blood was collected to evaluate various biochemical parameters. During laparotomy, reproductive performance parameters were recorded, and fetuses were weighed and the anomalies analyzed. Reduced placental efficiency and fetal growth restriction were observed in the group treated with 400 mg/kg of M. citrifolia extract. The highest dose (750 mg/kg) augmented aspartate aminotransferase concentration and preimplantation losses, while reducing the number of live fetuses. Furthermore, both doses (400 and 750 mg/kg) of the plant extract caused fetal anomalies. In conclusion, consumption of high doses of the M. citrifolia aqueous extrac during pregnancy leads to maternal hepatotoxicity, anti-implantation effects, intrauterine growth restriction and fetal abnormalities, indicating that the plant fruit extract can be harmful to both the mother and the fetus.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T20:52:08Z
2023-03-01T20:52:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/01480545.2022.2070197
Drug and Chemical Toxicology.
1525-6014
0148-0545
http://hdl.handle.net/11449/241216
10.1080/01480545.2022.2070197
2-s2.0-85132674215
url http://dx.doi.org/10.1080/01480545.2022.2070197
http://hdl.handle.net/11449/241216
identifier_str_mv Drug and Chemical Toxicology.
1525-6014
0148-0545
10.1080/01480545.2022.2070197
2-s2.0-85132674215
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Drug and Chemical Toxicology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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