Strength training reduces lipid accumulation in liver of obese Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.lfs.2019.116834 http://hdl.handle.net/11449/189617 |
Resumo: | Obesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats. Aims: Our aim is to evaluate the effects of high fat diet and strength training on markers of oxidation and lipogenesis in the liver of Wistar rats. Main methods: Forty Wistar rats were divided into four groups (n = 10): control (CTL), strength training (TR), high fat diet consumption (HF) and high fat diet consumption with strength training (HFT). Animals were subjected to physical strength training and high fat diet consumption for 12 weeks, 3 session per week. Then, the animals were euthanized, and liver markers were evaluated via immunolabeling. Key findings: Our results indicated that strength training reduced the expression of adiposity as well as the accumulation of glycogen and lipids in the liver. This reduction of fatty acid (FA) stored in hepatocytes is related to reduction of proteins linked to β-oxidation such as Fas/CD95, LIMP-II and CD36, as well as other proteins linked to lipogeneses such as SREBP-1. Significance: Finally, we observed that high fat diet can alter lipogenesis and reduce β-oxidation promoted hepatic fat accumulation. In conclusion, there was a reduction of obesity-related hepatic lipogenesis after 12 weeks of strength training. |
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Repositório Institucional da UNESP |
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spelling |
Strength training reduces lipid accumulation in liver of obese Wistar ratsAnaerobic trainingCD36LiverObesitySREBP-1Strength trainingObesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats. Aims: Our aim is to evaluate the effects of high fat diet and strength training on markers of oxidation and lipogenesis in the liver of Wistar rats. Main methods: Forty Wistar rats were divided into four groups (n = 10): control (CTL), strength training (TR), high fat diet consumption (HF) and high fat diet consumption with strength training (HFT). Animals were subjected to physical strength training and high fat diet consumption for 12 weeks, 3 session per week. Then, the animals were euthanized, and liver markers were evaluated via immunolabeling. Key findings: Our results indicated that strength training reduced the expression of adiposity as well as the accumulation of glycogen and lipids in the liver. This reduction of fatty acid (FA) stored in hepatocytes is related to reduction of proteins linked to β-oxidation such as Fas/CD95, LIMP-II and CD36, as well as other proteins linked to lipogeneses such as SREBP-1. Significance: Finally, we observed that high fat diet can alter lipogenesis and reduce β-oxidation promoted hepatic fat accumulation. In conclusion, there was a reduction of obesity-related hepatic lipogenesis after 12 weeks of strength training.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Postgraduate Program in Movement Sciences São Paulo State University-UNESP, campus of Presidente PrudenteDepartment of Physiotherapy School of Technology and Sciences UNESP, campus of Presidente PrudenteGraduated Physical Education São Paulo State University-UNESP, campus of Presidente PrudenteDepartment of Plant Agriculture University of GuelphPostgraduate Program in Movement Sciences São Paulo State University-UNESP, campus of Presidente PrudenteDepartment of Physiotherapy School of Technology and Sciences UNESP, campus of Presidente PrudenteGraduated Physical Education São Paulo State University-UNESP, campus of Presidente PrudenteCAPES: 001Universidade Estadual Paulista (Unesp)University of Guelphdos Santos, Giulia Fonseca [UNESP]Veras, Allice Santos Cruz [UNESP]de Freitas, Marcelo Conrado [UNESP]McCabe, JamesSeraphim, Patrícia Monteiro [UNESP]Teixeira, Giovana Rampazzo [UNESP]2019-10-06T16:46:22Z2019-10-06T16:46:22Z2019-10-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.lfs.2019.116834Life Sciences, v. 235.1879-06310024-3205http://hdl.handle.net/11449/18961710.1016/j.lfs.2019.1168342-s2.0-8507186276904110085990708710000-0003-2145-6640Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciencesinfo:eu-repo/semantics/openAccess2024-06-18T18:44:02Zoai:repositorio.unesp.br:11449/189617Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:44:51.609487Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
title |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
spellingShingle |
Strength training reduces lipid accumulation in liver of obese Wistar rats dos Santos, Giulia Fonseca [UNESP] Anaerobic training CD36 Liver Obesity SREBP-1 Strength training |
title_short |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
title_full |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
title_fullStr |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
title_full_unstemmed |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
title_sort |
Strength training reduces lipid accumulation in liver of obese Wistar rats |
author |
dos Santos, Giulia Fonseca [UNESP] |
author_facet |
dos Santos, Giulia Fonseca [UNESP] Veras, Allice Santos Cruz [UNESP] de Freitas, Marcelo Conrado [UNESP] McCabe, James Seraphim, Patrícia Monteiro [UNESP] Teixeira, Giovana Rampazzo [UNESP] |
author_role |
author |
author2 |
Veras, Allice Santos Cruz [UNESP] de Freitas, Marcelo Conrado [UNESP] McCabe, James Seraphim, Patrícia Monteiro [UNESP] Teixeira, Giovana Rampazzo [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) University of Guelph |
dc.contributor.author.fl_str_mv |
dos Santos, Giulia Fonseca [UNESP] Veras, Allice Santos Cruz [UNESP] de Freitas, Marcelo Conrado [UNESP] McCabe, James Seraphim, Patrícia Monteiro [UNESP] Teixeira, Giovana Rampazzo [UNESP] |
dc.subject.por.fl_str_mv |
Anaerobic training CD36 Liver Obesity SREBP-1 Strength training |
topic |
Anaerobic training CD36 Liver Obesity SREBP-1 Strength training |
description |
Obesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats. Aims: Our aim is to evaluate the effects of high fat diet and strength training on markers of oxidation and lipogenesis in the liver of Wistar rats. Main methods: Forty Wistar rats were divided into four groups (n = 10): control (CTL), strength training (TR), high fat diet consumption (HF) and high fat diet consumption with strength training (HFT). Animals were subjected to physical strength training and high fat diet consumption for 12 weeks, 3 session per week. Then, the animals were euthanized, and liver markers were evaluated via immunolabeling. Key findings: Our results indicated that strength training reduced the expression of adiposity as well as the accumulation of glycogen and lipids in the liver. This reduction of fatty acid (FA) stored in hepatocytes is related to reduction of proteins linked to β-oxidation such as Fas/CD95, LIMP-II and CD36, as well as other proteins linked to lipogeneses such as SREBP-1. Significance: Finally, we observed that high fat diet can alter lipogenesis and reduce β-oxidation promoted hepatic fat accumulation. In conclusion, there was a reduction of obesity-related hepatic lipogenesis after 12 weeks of strength training. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:46:22Z 2019-10-06T16:46:22Z 2019-10-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.lfs.2019.116834 Life Sciences, v. 235. 1879-0631 0024-3205 http://hdl.handle.net/11449/189617 10.1016/j.lfs.2019.116834 2-s2.0-85071862769 0411008599070871 0000-0003-2145-6640 |
url |
http://dx.doi.org/10.1016/j.lfs.2019.116834 http://hdl.handle.net/11449/189617 |
identifier_str_mv |
Life Sciences, v. 235. 1879-0631 0024-3205 10.1016/j.lfs.2019.116834 2-s2.0-85071862769 0411008599070871 0000-0003-2145-6640 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128973416169472 |