Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO)
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.4236/msa.2013.411085 |
Texto Completo: | http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=39639#.VUvK5I7BwXA http://hdl.handle.net/11449/123628 |
Resumo: | In this paper, a novel solid state Nitric Oxide (NO) sensor made of a spin trap (iron(II)-diethyldithiocarbamate complex, FeDETC) encapsulated in a siloxane-poly(oxypropylene) (PPO) matrix was developed. Nitric oxide (NO), a free radical molecule, has numerous roles in various physiological functions, such as the regulation of blood pressure, immune re- sponse to bacterial infection, and nervous systems. Siloxane-polyether hybrid materials, for example siloxane- poly(oxypropylene) (PPO), are easy to prepare, transparent and flexible. The combination of all these characteristics in a unique material allows it to be used in several scientific and technological areas, including human health. NO radical is trapped in FeDETC, which allows its detection by electron paramagnetic resonance (EPR). FeDETC was added while PPO was a sol, which was then left in air for gelation. The novel sensor was dived directly into a solution of NO, when the NO-FeDETC complex was formed. Our results show that the novel sensor responds to NO, with similar sensitivity as previously published sensors. PPO sensors present a strong EPR signal and a high stability, keeping its signal for 45 days. We have studied ways to accelerate the NO release from the sensor, in order to study its potential as a drug delivery system. We observed an acceleration in NO release by using a modulated magnetic field of 40 G at 100 kHz; as well as by UV irradiation. Thermal induced NO release was also tested by heating NO-FeDETC PPO up to 50°C, with good results. |
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Repositório Institucional da UNESP |
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Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO)PPOdrug deliveryEPRIn this paper, a novel solid state Nitric Oxide (NO) sensor made of a spin trap (iron(II)-diethyldithiocarbamate complex, FeDETC) encapsulated in a siloxane-poly(oxypropylene) (PPO) matrix was developed. Nitric oxide (NO), a free radical molecule, has numerous roles in various physiological functions, such as the regulation of blood pressure, immune re- sponse to bacterial infection, and nervous systems. Siloxane-polyether hybrid materials, for example siloxane- poly(oxypropylene) (PPO), are easy to prepare, transparent and flexible. The combination of all these characteristics in a unique material allows it to be used in several scientific and technological areas, including human health. NO radical is trapped in FeDETC, which allows its detection by electron paramagnetic resonance (EPR). FeDETC was added while PPO was a sol, which was then left in air for gelation. The novel sensor was dived directly into a solution of NO, when the NO-FeDETC complex was formed. Our results show that the novel sensor responds to NO, with similar sensitivity as previously published sensors. PPO sensors present a strong EPR signal and a high stability, keeping its signal for 45 days. We have studied ways to accelerate the NO release from the sensor, in order to study its potential as a drug delivery system. We observed an acceleration in NO release by using a modulated magnetic field of 40 G at 100 kHz; as well as by UV irradiation. Thermal induced NO release was also tested by heating NO-FeDETC PPO up to 50°C, with good results.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Faculdade de Araraquara - Ciências Farmacêuticas, Centro, CEP 14801902, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências e Letras de AssisUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Física, Faculdade de Ciências de BauruUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de AraraquaraUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Herculano, Rondinelli Donizetti [UNESP]Brunello, Carlos AlbertoMelo Junior, Jair Pereira deMartins, Mayler [UNESP]Borges, Felipe Azevedo [UNESP]Chiavacci, Leila [UNESP]Graeff, Carlos Frederico de Oliveira [UNESP]2015-05-15T13:30:31Z2015-05-15T13:30:31Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article683-688application/pdfhttp://www.scirp.org/Journal/PaperInformation.aspx?PaperID=39639#.VUvK5I7BwXAMaterials Sciences and Applications, v. 4, n. 11, p. 683-688, 2013.2153-117Xhttp://hdl.handle.net/11449/12362810.4236/msa.2013.411085ISSN2153-117X-2013-04-11-683-688.pdf574340804275324452686076842232810000-0003-0162-8273Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Sciences and Applicationsinfo:eu-repo/semantics/openAccess2024-06-24T13:45:29Zoai:repositorio.unesp.br:11449/123628Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:47:14.477886Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
title |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
spellingShingle |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) Herculano, Rondinelli Donizetti [UNESP] PPO drug delivery EPR Herculano, Rondinelli Donizetti [UNESP] PPO drug delivery EPR |
title_short |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
title_full |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
title_fullStr |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
title_full_unstemmed |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
title_sort |
Novel solid state nitric oxide sensor using siloxane-poly (oxypropylene) (PPO) |
author |
Herculano, Rondinelli Donizetti [UNESP] |
author_facet |
Herculano, Rondinelli Donizetti [UNESP] Herculano, Rondinelli Donizetti [UNESP] Brunello, Carlos Alberto Melo Junior, Jair Pereira de Martins, Mayler [UNESP] Borges, Felipe Azevedo [UNESP] Chiavacci, Leila [UNESP] Graeff, Carlos Frederico de Oliveira [UNESP] Brunello, Carlos Alberto Melo Junior, Jair Pereira de Martins, Mayler [UNESP] Borges, Felipe Azevedo [UNESP] Chiavacci, Leila [UNESP] Graeff, Carlos Frederico de Oliveira [UNESP] |
author_role |
author |
author2 |
Brunello, Carlos Alberto Melo Junior, Jair Pereira de Martins, Mayler [UNESP] Borges, Felipe Azevedo [UNESP] Chiavacci, Leila [UNESP] Graeff, Carlos Frederico de Oliveira [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Herculano, Rondinelli Donizetti [UNESP] Brunello, Carlos Alberto Melo Junior, Jair Pereira de Martins, Mayler [UNESP] Borges, Felipe Azevedo [UNESP] Chiavacci, Leila [UNESP] Graeff, Carlos Frederico de Oliveira [UNESP] |
dc.subject.por.fl_str_mv |
PPO drug delivery EPR |
topic |
PPO drug delivery EPR |
description |
In this paper, a novel solid state Nitric Oxide (NO) sensor made of a spin trap (iron(II)-diethyldithiocarbamate complex, FeDETC) encapsulated in a siloxane-poly(oxypropylene) (PPO) matrix was developed. Nitric oxide (NO), a free radical molecule, has numerous roles in various physiological functions, such as the regulation of blood pressure, immune re- sponse to bacterial infection, and nervous systems. Siloxane-polyether hybrid materials, for example siloxane- poly(oxypropylene) (PPO), are easy to prepare, transparent and flexible. The combination of all these characteristics in a unique material allows it to be used in several scientific and technological areas, including human health. NO radical is trapped in FeDETC, which allows its detection by electron paramagnetic resonance (EPR). FeDETC was added while PPO was a sol, which was then left in air for gelation. The novel sensor was dived directly into a solution of NO, when the NO-FeDETC complex was formed. Our results show that the novel sensor responds to NO, with similar sensitivity as previously published sensors. PPO sensors present a strong EPR signal and a high stability, keeping its signal for 45 days. We have studied ways to accelerate the NO release from the sensor, in order to study its potential as a drug delivery system. We observed an acceleration in NO release by using a modulated magnetic field of 40 G at 100 kHz; as well as by UV irradiation. Thermal induced NO release was also tested by heating NO-FeDETC PPO up to 50°C, with good results. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2015-05-15T13:30:31Z 2015-05-15T13:30:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=39639#.VUvK5I7BwXA Materials Sciences and Applications, v. 4, n. 11, p. 683-688, 2013. 2153-117X http://hdl.handle.net/11449/123628 10.4236/msa.2013.411085 ISSN2153-117X-2013-04-11-683-688.pdf 5743408042753244 5268607684223281 0000-0003-0162-8273 |
url |
http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=39639#.VUvK5I7BwXA http://hdl.handle.net/11449/123628 |
identifier_str_mv |
Materials Sciences and Applications, v. 4, n. 11, p. 683-688, 2013. 2153-117X 10.4236/msa.2013.411085 ISSN2153-117X-2013-04-11-683-688.pdf 5743408042753244 5268607684223281 0000-0003-0162-8273 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Sciences and Applications |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
683-688 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1822182390823387136 |
dc.identifier.doi.none.fl_str_mv |
10.4236/msa.2013.411085 |