Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/14786419.2018.1460827 http://hdl.handle.net/11449/177114 |
Resumo: | Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 μg/mL), C. parapsilosis (78 μg/mL), C. krusei (19 μg/mL), Trichophyton rubrum (78 μg/mL) and Microsporum canis (156 μg/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum. |
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Repositório Institucional da UNESP |
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Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activityAntifungal agentdermatophytemyricetinnon-albicansPlinia caulifloraquercetinPlinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 μg/mL), C. parapsilosis (78 μg/mL), C. krusei (19 μg/mL), Trichophyton rubrum (78 μg/mL) and Microsporum canis (156 μg/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum.Department of Drugs and Medicines, São Paulo State University-UNESP, Araraquara, BrazilDepartment of Organic Chemistry, São Paulo State University-UNESP, Araraquara, BrazilUniversidade Estadual Paulista (Unesp)Souza-Moreira, Tatiana M.Severi, Juliana A.Rodrigues, Edvânio Ramosde Paula, Mayara IvaniFreitas, Jolindo A.Vilegas, WagnerPietro, Rosemeire C. L. R.2018-12-11T17:24:03Z2018-12-11T17:24:03Z2018-04-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://dx.doi.org/10.1080/14786419.2018.1460827Natural Product Research, p. 1-4.1478-64271478-6419http://hdl.handle.net/11449/17711410.1080/14786419.2018.14608272-s2.0-850450548642-s2.0-85045054864.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Research0,671info:eu-repo/semantics/openAccess2024-06-24T13:46:00Zoai:repositorio.unesp.br:11449/177114Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:46.287917Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
title |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
spellingShingle |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity Souza-Moreira, Tatiana M. Antifungal agent dermatophyte myricetin non-albicans Plinia cauliflora quercetin |
title_short |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
title_full |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
title_fullStr |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
title_full_unstemmed |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
title_sort |
Flavonoids from Plinia cauliflora (Mart.) Kausel (Myrtaceae) with antifungal activity |
author |
Souza-Moreira, Tatiana M. |
author_facet |
Souza-Moreira, Tatiana M. Severi, Juliana A. Rodrigues, Edvânio Ramos de Paula, Mayara Ivani Freitas, Jolindo A. Vilegas, Wagner Pietro, Rosemeire C. L. R. |
author_role |
author |
author2 |
Severi, Juliana A. Rodrigues, Edvânio Ramos de Paula, Mayara Ivani Freitas, Jolindo A. Vilegas, Wagner Pietro, Rosemeire C. L. R. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Souza-Moreira, Tatiana M. Severi, Juliana A. Rodrigues, Edvânio Ramos de Paula, Mayara Ivani Freitas, Jolindo A. Vilegas, Wagner Pietro, Rosemeire C. L. R. |
dc.subject.por.fl_str_mv |
Antifungal agent dermatophyte myricetin non-albicans Plinia cauliflora quercetin |
topic |
Antifungal agent dermatophyte myricetin non-albicans Plinia cauliflora quercetin |
description |
Plinia cauliflora is a plant species with edible fruits but its chemical composition is not totally known yet although former studies showed its potential as antifungal agent. This work aimed the chemical analysis of the leaves, the activity against fungi species and evaluated cytotoxicity. Extract was obtained with 70% ethanol. An ethyl acetate fraction was obtained and glycosylated quercetin and myricetin were isolated. Samples were tested against Candida species, dermatophytes and entomopathogenic fungi. Cytotoxicity was evaluated against fibroblast cells. Extract showed good activity against C. albicans (minimum inhibitory concentration at 156 μg/mL), C. parapsilosis (78 μg/mL), C. krusei (19 μg/mL), Trichophyton rubrum (78 μg/mL) and Microsporum canis (156 μg/mL). Isolated compounds were more active against C. krusei and T. rubrum. The extract, which was the more active sample, demonstrated low cytotoxic effect and encourage more studies against rising non-albicans species and dermatophyte T. rubrum. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:24:03Z 2018-12-11T17:24:03Z 2018-04-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/14786419.2018.1460827 Natural Product Research, p. 1-4. 1478-6427 1478-6419 http://hdl.handle.net/11449/177114 10.1080/14786419.2018.1460827 2-s2.0-85045054864 2-s2.0-85045054864.pdf |
url |
http://dx.doi.org/10.1080/14786419.2018.1460827 http://hdl.handle.net/11449/177114 |
identifier_str_mv |
Natural Product Research, p. 1-4. 1478-6427 1478-6419 10.1080/14786419.2018.1460827 2-s2.0-85045054864 2-s2.0-85045054864.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Natural Product Research 0,671 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-4 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129137116708864 |