Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis

Detalhes bibliográficos
Autor(a) principal: Herculano, Rondinelli Donizetti [UNESP]
Data de Publicação: 2023
Outros Autores: dos Santos, Thainá Oliveira [UNESP], de Barros, Natan Roberto, Pegorin Brasil, Giovana Sant'Ana [UNESP], Scontri, Mateus [UNESP], Carvalho, Bruna Gregatti, Mecwan, Marvin, Farhadi, Neda, Kawakita, Satoru, Perego, Caio Humberto [UNESP], Carvalho, Flávio Alexandre [UNESP], dos Santos, André Gonzaga [UNESP], Guerra, Nayrim Brizuela, Floriano, Juliana Ferreira [UNESP], Mussagy, Cassamo Ussemane, Tirpáková, Zuzana, Khorsandi, Danial, Peirsman, Arne, Nguyen, Huu Tuan, Gomez, Alejandro, Mandal, Kalpana, de Mendonça, Ricardo José, Li, Bingbing, Dokmeci, Mehmet Remzi, Jucaud, Vadim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.ijbiomac.2023.124779
http://hdl.handle.net/11449/249937
Resumo: Psoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera-releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that ~70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically.
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spelling Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasisAloe veraComplementary treatmentNatural rubber latexOcclusive dressingPsoriasisPsoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera-releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that ~70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SPTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic BlvdAutonomy Research Center for STEAHM (ARCS) California State UniversitySão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SPUniversity of Campinas (UNICAMP) Department of Materials and Bioprocesses Engineering School of Chemical Engineering, SPSão Paulo State University (UNESP) Pharmacognosy Laboratory School of Pharmaceutical Sciences, SPArea of Exact Sciences and Engineering University of Caxias do Sul (UCS), RSEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de ValparaísoThe University of Veterinary Medicine and Pharmacy in Košice, KomenskéhoPlastic Reconstructive and Aesthetic Surgery University Hospital GhentDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), MGSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SPSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SPSão Paulo State University (UNESP) Pharmacognosy Laboratory School of Pharmaceutical Sciences, SPFAPESP: 2017/19603-8FAPESP: 2018/07342-8FAPESP: 2021/09207-3CNPq: 317203/2021-5CNPq: 401285/2022-7CNPq: 470261/2012-9Universidade Estadual Paulista (UNESP)Terasaki Institute for Biomedical Innovation (TIBI)California State UniversityUniversidade Estadual de Campinas (UNICAMP)University of Caxias do Sul (UCS)Pontificia Universidad Católica de ValparaísoThe University of Veterinary Medicine and Pharmacy in KošiceReconstructive and Aesthetic Surgery University Hospital GhentFederal University of Triangulo Mineiro (UFTM)Herculano, Rondinelli Donizetti [UNESP]dos Santos, Thainá Oliveira [UNESP]de Barros, Natan RobertoPegorin Brasil, Giovana Sant'Ana [UNESP]Scontri, Mateus [UNESP]Carvalho, Bruna GregattiMecwan, MarvinFarhadi, NedaKawakita, SatoruPerego, Caio Humberto [UNESP]Carvalho, Flávio Alexandre [UNESP]dos Santos, André Gonzaga [UNESP]Guerra, Nayrim BrizuelaFloriano, Juliana Ferreira [UNESP]Mussagy, Cassamo UssemaneTirpáková, ZuzanaKhorsandi, DanialPeirsman, ArneNguyen, Huu TuanGomez, AlejandroMandal, Kalpanade Mendonça, Ricardo JoséLi, BingbingDokmeci, Mehmet RemziJucaud, Vadim2023-07-29T16:13:16Z2023-07-29T16:13:16Z2023-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ijbiomac.2023.124779International Journal of Biological Macromolecules, v. 242.1879-00030141-8130http://hdl.handle.net/11449/24993710.1016/j.ijbiomac.2023.1247792-s2.0-85158892748Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Biological Macromoleculesinfo:eu-repo/semantics/openAccess2024-06-13T17:38:43Zoai:repositorio.unesp.br:11449/249937Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:31:34.219558Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
title Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
spellingShingle Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
Herculano, Rondinelli Donizetti [UNESP]
Aloe vera
Complementary treatment
Natural rubber latex
Occlusive dressing
Psoriasis
title_short Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
title_full Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
title_fullStr Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
title_full_unstemmed Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
title_sort Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
author Herculano, Rondinelli Donizetti [UNESP]
author_facet Herculano, Rondinelli Donizetti [UNESP]
dos Santos, Thainá Oliveira [UNESP]
de Barros, Natan Roberto
Pegorin Brasil, Giovana Sant'Ana [UNESP]
Scontri, Mateus [UNESP]
Carvalho, Bruna Gregatti
Mecwan, Marvin
Farhadi, Neda
Kawakita, Satoru
Perego, Caio Humberto [UNESP]
Carvalho, Flávio Alexandre [UNESP]
dos Santos, André Gonzaga [UNESP]
Guerra, Nayrim Brizuela
Floriano, Juliana Ferreira [UNESP]
Mussagy, Cassamo Ussemane
Tirpáková, Zuzana
Khorsandi, Danial
Peirsman, Arne
Nguyen, Huu Tuan
Gomez, Alejandro
Mandal, Kalpana
de Mendonça, Ricardo José
Li, Bingbing
Dokmeci, Mehmet Remzi
Jucaud, Vadim
author_role author
author2 dos Santos, Thainá Oliveira [UNESP]
de Barros, Natan Roberto
Pegorin Brasil, Giovana Sant'Ana [UNESP]
Scontri, Mateus [UNESP]
Carvalho, Bruna Gregatti
Mecwan, Marvin
Farhadi, Neda
Kawakita, Satoru
Perego, Caio Humberto [UNESP]
Carvalho, Flávio Alexandre [UNESP]
dos Santos, André Gonzaga [UNESP]
Guerra, Nayrim Brizuela
Floriano, Juliana Ferreira [UNESP]
Mussagy, Cassamo Ussemane
Tirpáková, Zuzana
Khorsandi, Danial
Peirsman, Arne
Nguyen, Huu Tuan
Gomez, Alejandro
Mandal, Kalpana
de Mendonça, Ricardo José
Li, Bingbing
Dokmeci, Mehmet Remzi
Jucaud, Vadim
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Terasaki Institute for Biomedical Innovation (TIBI)
California State University
Universidade Estadual de Campinas (UNICAMP)
University of Caxias do Sul (UCS)
Pontificia Universidad Católica de Valparaíso
The University of Veterinary Medicine and Pharmacy in Košice
Reconstructive and Aesthetic Surgery University Hospital Ghent
Federal University of Triangulo Mineiro (UFTM)
dc.contributor.author.fl_str_mv Herculano, Rondinelli Donizetti [UNESP]
dos Santos, Thainá Oliveira [UNESP]
de Barros, Natan Roberto
Pegorin Brasil, Giovana Sant'Ana [UNESP]
Scontri, Mateus [UNESP]
Carvalho, Bruna Gregatti
Mecwan, Marvin
Farhadi, Neda
Kawakita, Satoru
Perego, Caio Humberto [UNESP]
Carvalho, Flávio Alexandre [UNESP]
dos Santos, André Gonzaga [UNESP]
Guerra, Nayrim Brizuela
Floriano, Juliana Ferreira [UNESP]
Mussagy, Cassamo Ussemane
Tirpáková, Zuzana
Khorsandi, Danial
Peirsman, Arne
Nguyen, Huu Tuan
Gomez, Alejandro
Mandal, Kalpana
de Mendonça, Ricardo José
Li, Bingbing
Dokmeci, Mehmet Remzi
Jucaud, Vadim
dc.subject.por.fl_str_mv Aloe vera
Complementary treatment
Natural rubber latex
Occlusive dressing
Psoriasis
topic Aloe vera
Complementary treatment
Natural rubber latex
Occlusive dressing
Psoriasis
description Psoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera-releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that ~70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T16:13:16Z
2023-07-29T16:13:16Z
2023-07-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.ijbiomac.2023.124779
International Journal of Biological Macromolecules, v. 242.
1879-0003
0141-8130
http://hdl.handle.net/11449/249937
10.1016/j.ijbiomac.2023.124779
2-s2.0-85158892748
url http://dx.doi.org/10.1016/j.ijbiomac.2023.124779
http://hdl.handle.net/11449/249937
identifier_str_mv International Journal of Biological Macromolecules, v. 242.
1879-0003
0141-8130
10.1016/j.ijbiomac.2023.124779
2-s2.0-85158892748
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal of Biological Macromolecules
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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