Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study

Detalhes bibliográficos
Autor(a) principal: Rodrigues, F. S. [UNESP]
Data de Publicação: 2019
Outros Autores: Clemente de Luca, F. A. [UNESP], Ribeiro da Cunha, A. [UNESP], Fortaleza, C. M. C. B. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jhin.2018.06.015
http://hdl.handle.net/11449/185347
Resumo: Background: Recent studies reported seasonality in healthcare-associated infections (HCAI). The association of this phenomenon with other risk factors for HCAI is not clear. Aim: To analyse the interplay of season, weather and usual predictors of healthcare-associated bloodstream infections caused by Gram-negative bacilli (GNB-BSI). Methods: A case-only study was conducted in a teaching hospital in Brazil. The study enrolled 446 subjects with GNB-BSI diagnosed from July 2012 to June 2016. Demographic data, comorbidities, invasive procedures and use of antimicrobials were reviewed in medical charts. The season in which GNB-BSI occurred, and weather parameters on the day of diagnosis were recorded. Factors associated with occurrence of GNB-BSI in different seasons (reference category: winter) and caused by different GNB (reference category: Escherichia coli) were analysed. Uni- and multi-variable models of multi-nomial logistic regression were used for analysis. Findings: GNB-BSI diagnosed in summer was more likely to be caused by Klebsiella spp. [odds ratio (OR) 5.33; 95% confidence interval (CI) 2.04-13.96] or Acinetobacter baumannii (OR 2.69; 95% CI 1.04-6.96), and there was an association between Klebsiella spp. and spring (OR 2.86; 95% CI 1.14-7.18). Average temperature on the day of diagnosis was associated with Klebsiella spp. (OR 1.19; 95% CI 1.07-1.33) and A. baumannii (OR 1.20; 95% CI 1.07-1.34). Conclusion: Warm seasons and daily temperature impact on the aetiology of GNB-BSI, even in models adjusted for usual risk factors. One possible explanation for these findings is that seasonality of healthcare-associated pathogens is intrinsic to micro-organisms, and not associated with comorbidities, procedures or use of antimicrobials. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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spelling Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only studyBloodstream infectionsGram-negativeSeasonalityWeatherBackground: Recent studies reported seasonality in healthcare-associated infections (HCAI). The association of this phenomenon with other risk factors for HCAI is not clear. Aim: To analyse the interplay of season, weather and usual predictors of healthcare-associated bloodstream infections caused by Gram-negative bacilli (GNB-BSI). Methods: A case-only study was conducted in a teaching hospital in Brazil. The study enrolled 446 subjects with GNB-BSI diagnosed from July 2012 to June 2016. Demographic data, comorbidities, invasive procedures and use of antimicrobials were reviewed in medical charts. The season in which GNB-BSI occurred, and weather parameters on the day of diagnosis were recorded. Factors associated with occurrence of GNB-BSI in different seasons (reference category: winter) and caused by different GNB (reference category: Escherichia coli) were analysed. Uni- and multi-variable models of multi-nomial logistic regression were used for analysis. Findings: GNB-BSI diagnosed in summer was more likely to be caused by Klebsiella spp. [odds ratio (OR) 5.33; 95% confidence interval (CI) 2.04-13.96] or Acinetobacter baumannii (OR 2.69; 95% CI 1.04-6.96), and there was an association between Klebsiella spp. and spring (OR 2.86; 95% CI 1.14-7.18). Average temperature on the day of diagnosis was associated with Klebsiella spp. (OR 1.19; 95% CI 1.07-1.33) and A. baumannii (OR 1.20; 95% CI 1.07-1.34). Conclusion: Warm seasons and daily temperature impact on the aetiology of GNB-BSI, even in models adjusted for usual risk factors. One possible explanation for these findings is that seasonality of healthcare-associated pathogens is intrinsic to micro-organisms, and not associated with comorbidities, procedures or use of antimicrobials. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Sao Paulo State Univ, Dept Trop Dis, Botucatu Med Sch, Botucatu, SP, BrazilSao Paulo State Univ, Fac Agron Sci, Botucatu, SP, BrazilSao Paulo State Univ, Dept Trop Dis, Botucatu Med Sch, Botucatu, SP, BrazilSao Paulo State Univ, Fac Agron Sci, Botucatu, SP, BrazilW B Saunders Co LtdUniversidade Estadual Paulista (Unesp)Rodrigues, F. S. [UNESP]Clemente de Luca, F. A. [UNESP]Ribeiro da Cunha, A. [UNESP]Fortaleza, C. M. C. B. [UNESP]2019-10-04T12:34:44Z2019-10-04T12:34:44Z2019-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article134-141http://dx.doi.org/10.1016/j.jhin.2018.06.015Journal Of Hospital Infection. London: W B Saunders Co Ltd, v. 101, n. 2, p. 134-141, 2019.0195-6701http://hdl.handle.net/11449/18534710.1016/j.jhin.2018.06.015WOS:000456529400004Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Hospital Infectioninfo:eu-repo/semantics/openAccess2024-08-15T15:23:01Zoai:repositorio.unesp.br:11449/185347Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
title Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
spellingShingle Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
Rodrigues, F. S. [UNESP]
Bloodstream infections
Gram-negative
Seasonality
Weather
title_short Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
title_full Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
title_fullStr Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
title_full_unstemmed Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
title_sort Season, weather and predictors of healthcare-associated Gram-negative bloodstream infections: a case-only study
author Rodrigues, F. S. [UNESP]
author_facet Rodrigues, F. S. [UNESP]
Clemente de Luca, F. A. [UNESP]
Ribeiro da Cunha, A. [UNESP]
Fortaleza, C. M. C. B. [UNESP]
author_role author
author2 Clemente de Luca, F. A. [UNESP]
Ribeiro da Cunha, A. [UNESP]
Fortaleza, C. M. C. B. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rodrigues, F. S. [UNESP]
Clemente de Luca, F. A. [UNESP]
Ribeiro da Cunha, A. [UNESP]
Fortaleza, C. M. C. B. [UNESP]
dc.subject.por.fl_str_mv Bloodstream infections
Gram-negative
Seasonality
Weather
topic Bloodstream infections
Gram-negative
Seasonality
Weather
description Background: Recent studies reported seasonality in healthcare-associated infections (HCAI). The association of this phenomenon with other risk factors for HCAI is not clear. Aim: To analyse the interplay of season, weather and usual predictors of healthcare-associated bloodstream infections caused by Gram-negative bacilli (GNB-BSI). Methods: A case-only study was conducted in a teaching hospital in Brazil. The study enrolled 446 subjects with GNB-BSI diagnosed from July 2012 to June 2016. Demographic data, comorbidities, invasive procedures and use of antimicrobials were reviewed in medical charts. The season in which GNB-BSI occurred, and weather parameters on the day of diagnosis were recorded. Factors associated with occurrence of GNB-BSI in different seasons (reference category: winter) and caused by different GNB (reference category: Escherichia coli) were analysed. Uni- and multi-variable models of multi-nomial logistic regression were used for analysis. Findings: GNB-BSI diagnosed in summer was more likely to be caused by Klebsiella spp. [odds ratio (OR) 5.33; 95% confidence interval (CI) 2.04-13.96] or Acinetobacter baumannii (OR 2.69; 95% CI 1.04-6.96), and there was an association between Klebsiella spp. and spring (OR 2.86; 95% CI 1.14-7.18). Average temperature on the day of diagnosis was associated with Klebsiella spp. (OR 1.19; 95% CI 1.07-1.33) and A. baumannii (OR 1.20; 95% CI 1.07-1.34). Conclusion: Warm seasons and daily temperature impact on the aetiology of GNB-BSI, even in models adjusted for usual risk factors. One possible explanation for these findings is that seasonality of healthcare-associated pathogens is intrinsic to micro-organisms, and not associated with comorbidities, procedures or use of antimicrobials. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-04T12:34:44Z
2019-10-04T12:34:44Z
2019-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jhin.2018.06.015
Journal Of Hospital Infection. London: W B Saunders Co Ltd, v. 101, n. 2, p. 134-141, 2019.
0195-6701
http://hdl.handle.net/11449/185347
10.1016/j.jhin.2018.06.015
WOS:000456529400004
url http://dx.doi.org/10.1016/j.jhin.2018.06.015
http://hdl.handle.net/11449/185347
identifier_str_mv Journal Of Hospital Infection. London: W B Saunders Co Ltd, v. 101, n. 2, p. 134-141, 2019.
0195-6701
10.1016/j.jhin.2018.06.015
WOS:000456529400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Hospital Infection
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 134-141
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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