Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fnbeh.2022.1077368 http://hdl.handle.net/11449/249595 |
Resumo: | Cohabitation with a partner undergoing chronic restraint stress (CRE) induces anxiogenic-like behaviors through emotional contagion. We hypothesized that the anterior cingulate cortex (ACC) and the amygdala would be involved in the modulation of this emotional process. This study investigated the role of the ACC and amygdala in empathy-like behavior (e.g., anxiety-like responses) induced by living with a mouse subjected to CRE. Male Swiss mice were housed in pairs for 14 days and then allocated into two groups: cagemate stress (one animal of the pair was subjected to 14 days of restraint stress) and cagemate control (no animal experienced stress). Twenty-four hours after the last stress session, cagemates had their brains removed for recording FosB labeling in the ACC and amygdala (Exp.1). In experiments 2 and 3, 24 h after the last stress session, the cagemates received 0.1 μL of saline or cobalt chloride (CoCl2 1 mM) into the ACC or amygdala, and then exposed to the elevated plus-maze (EPM) for recording anxiety. Results showed a decrease of FosB labeling in the ACC without changing immunofluorescence in the amygdala of stress cagemate mice. Cohabitation with mice subjected to CRE provoked anxiogenic-like behaviors. Local inactivation of ACC (but not the amygdala) reversed the anxiogenic-like effects induced by cohabitation with a partner undergoing CRE. These results suggest the involvement of ACC, but not the amygdala, in anxiety induced by emotional contagion. |
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Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male miceamygdalaanterior cingulate cortexanxietychronic restraint stressempathymiceCohabitation with a partner undergoing chronic restraint stress (CRE) induces anxiogenic-like behaviors through emotional contagion. We hypothesized that the anterior cingulate cortex (ACC) and the amygdala would be involved in the modulation of this emotional process. This study investigated the role of the ACC and amygdala in empathy-like behavior (e.g., anxiety-like responses) induced by living with a mouse subjected to CRE. Male Swiss mice were housed in pairs for 14 days and then allocated into two groups: cagemate stress (one animal of the pair was subjected to 14 days of restraint stress) and cagemate control (no animal experienced stress). Twenty-four hours after the last stress session, cagemates had their brains removed for recording FosB labeling in the ACC and amygdala (Exp.1). In experiments 2 and 3, 24 h after the last stress session, the cagemates received 0.1 μL of saline or cobalt chloride (CoCl2 1 mM) into the ACC or amygdala, and then exposed to the elevated plus-maze (EPM) for recording anxiety. Results showed a decrease of FosB labeling in the ACC without changing immunofluorescence in the amygdala of stress cagemate mice. Cohabitation with mice subjected to CRE provoked anxiogenic-like behaviors. Local inactivation of ACC (but not the amygdala) reversed the anxiogenic-like effects induced by cohabitation with a partner undergoing CRE. These results suggest the involvement of ACC, but not the amygdala, in anxiety induced by emotional contagion.Psychobiology Group Department of Psychology Centro de Educação e Ciências Humanas (CECH) Universidade Federal de São CarlosGraduate Program in Psychology Centro de Educação e Ciências Humanas (CECH)-Universidade Federal de São CarlosJoint Graduate Program in Physiological Sciences Universidade Federal de São Carlos (UFSCar)/Universidade Estadual Paulista (UNESP), São PauloLaboratory of Pharmacology School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP), São PauloInstitute of Neuroscience and BehaviourJoint Graduate Program in Physiological Sciences Universidade Federal de São Carlos (UFSCar)/Universidade Estadual Paulista (UNESP), São PauloLaboratory of Pharmacology School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP), São PauloUniversidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (UNESP)Institute of Neuroscience and BehaviourSilveira, Lara MariaTavares, Ligia Renata Rodrigues [UNESP]Baptista-de-Souza, Daniela [UNESP]Carmona, Isabela Miranda [UNESP]Carneiro de Oliveira, Paulo EduardoNunes-de-Souza, Ricardo Luiz [UNESP]Canto-de-Souza, Azair [UNESP]2023-07-29T16:04:03Z2023-07-29T16:04:03Z2023-01-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fnbeh.2022.1077368Frontiers in Behavioral Neuroscience, v. 16.1662-5153http://hdl.handle.net/11449/24959510.3389/fnbeh.2022.10773682-s2.0-85146794286Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Behavioral Neuroscienceinfo:eu-repo/semantics/openAccess2024-06-24T14:51:30Zoai:repositorio.unesp.br:11449/249595Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:50:33.362815Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
title |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
spellingShingle |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice Silveira, Lara Maria amygdala anterior cingulate cortex anxiety chronic restraint stress empathy mice |
title_short |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
title_full |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
title_fullStr |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
title_full_unstemmed |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
title_sort |
Anterior cingulate cortex, but not amygdala, modulates the anxiogenesis induced by living with conspecifics subjected to chronic restraint stress in male mice |
author |
Silveira, Lara Maria |
author_facet |
Silveira, Lara Maria Tavares, Ligia Renata Rodrigues [UNESP] Baptista-de-Souza, Daniela [UNESP] Carmona, Isabela Miranda [UNESP] Carneiro de Oliveira, Paulo Eduardo Nunes-de-Souza, Ricardo Luiz [UNESP] Canto-de-Souza, Azair [UNESP] |
author_role |
author |
author2 |
Tavares, Ligia Renata Rodrigues [UNESP] Baptista-de-Souza, Daniela [UNESP] Carmona, Isabela Miranda [UNESP] Carneiro de Oliveira, Paulo Eduardo Nunes-de-Souza, Ricardo Luiz [UNESP] Canto-de-Souza, Azair [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (UNESP) Institute of Neuroscience and Behaviour |
dc.contributor.author.fl_str_mv |
Silveira, Lara Maria Tavares, Ligia Renata Rodrigues [UNESP] Baptista-de-Souza, Daniela [UNESP] Carmona, Isabela Miranda [UNESP] Carneiro de Oliveira, Paulo Eduardo Nunes-de-Souza, Ricardo Luiz [UNESP] Canto-de-Souza, Azair [UNESP] |
dc.subject.por.fl_str_mv |
amygdala anterior cingulate cortex anxiety chronic restraint stress empathy mice |
topic |
amygdala anterior cingulate cortex anxiety chronic restraint stress empathy mice |
description |
Cohabitation with a partner undergoing chronic restraint stress (CRE) induces anxiogenic-like behaviors through emotional contagion. We hypothesized that the anterior cingulate cortex (ACC) and the amygdala would be involved in the modulation of this emotional process. This study investigated the role of the ACC and amygdala in empathy-like behavior (e.g., anxiety-like responses) induced by living with a mouse subjected to CRE. Male Swiss mice were housed in pairs for 14 days and then allocated into two groups: cagemate stress (one animal of the pair was subjected to 14 days of restraint stress) and cagemate control (no animal experienced stress). Twenty-four hours after the last stress session, cagemates had their brains removed for recording FosB labeling in the ACC and amygdala (Exp.1). In experiments 2 and 3, 24 h after the last stress session, the cagemates received 0.1 μL of saline or cobalt chloride (CoCl2 1 mM) into the ACC or amygdala, and then exposed to the elevated plus-maze (EPM) for recording anxiety. Results showed a decrease of FosB labeling in the ACC without changing immunofluorescence in the amygdala of stress cagemate mice. Cohabitation with mice subjected to CRE provoked anxiogenic-like behaviors. Local inactivation of ACC (but not the amygdala) reversed the anxiogenic-like effects induced by cohabitation with a partner undergoing CRE. These results suggest the involvement of ACC, but not the amygdala, in anxiety induced by emotional contagion. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T16:04:03Z 2023-07-29T16:04:03Z 2023-01-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fnbeh.2022.1077368 Frontiers in Behavioral Neuroscience, v. 16. 1662-5153 http://hdl.handle.net/11449/249595 10.3389/fnbeh.2022.1077368 2-s2.0-85146794286 |
url |
http://dx.doi.org/10.3389/fnbeh.2022.1077368 http://hdl.handle.net/11449/249595 |
identifier_str_mv |
Frontiers in Behavioral Neuroscience, v. 16. 1662-5153 10.3389/fnbeh.2022.1077368 2-s2.0-85146794286 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Behavioral Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128572798271488 |