Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.fct.2019.110813 http://hdl.handle.net/11449/189658 |
Resumo: | Zinc is required for fetal development and is involved in key processes associated with breast carcinogenesis. We evaluated whether maternal zinc deficiency or supplementation during gestation influences female offspring susceptibility to breast cancer in adulthood. C57BL/6 mice consumed during gestation control (30 p.p.m. zinc), zinc-deficient (8 p.p.m) or zinc-supplemented (45 p.p.m.) diets. Maternal zinc supplementation increased in female mice offspring the incidence of chemically-induced mammary adenocarcinomas that were heavier, compared to control group. This was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and Rassf1, Zfp382 and Stat3 expression in mammary glands, as well as increased zinc status. Although maternal zinc deficiency did not alter the incidence of these lesions, it also induced heavier mammary adenocarcinomas, compared to control group. These effects were accompanied by a decreased number of terminal end buds, increased proto-oncogenes c-Myc and Lmo4 expression and H3K9Me3 and H4K20Me3 epigenetic marks in mammary glands of offspring, and decreased zinc status and increased levels of oxidative marker malondialdehyde. The data suggest that both maternal zinc deficiency and supplementation during gestation programmed increased breast cancer susceptibility in adult mice offspring following a J-shaped pattern through distinct mechanisms. |
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Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanismsBreast cancerFetal programmingGestationMaternal nutritionZincZinc is required for fetal development and is involved in key processes associated with breast carcinogenesis. We evaluated whether maternal zinc deficiency or supplementation during gestation influences female offspring susceptibility to breast cancer in adulthood. C57BL/6 mice consumed during gestation control (30 p.p.m. zinc), zinc-deficient (8 p.p.m) or zinc-supplemented (45 p.p.m.) diets. Maternal zinc supplementation increased in female mice offspring the incidence of chemically-induced mammary adenocarcinomas that were heavier, compared to control group. This was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and Rassf1, Zfp382 and Stat3 expression in mammary glands, as well as increased zinc status. Although maternal zinc deficiency did not alter the incidence of these lesions, it also induced heavier mammary adenocarcinomas, compared to control group. These effects were accompanied by a decreased number of terminal end buds, increased proto-oncogenes c-Myc and Lmo4 expression and H3K9Me3 and H4K20Me3 epigenetic marks in mammary glands of offspring, and decreased zinc status and increased levels of oxidative marker malondialdehyde. The data suggest that both maternal zinc deficiency and supplementation during gestation programmed increased breast cancer susceptibility in adult mice offspring following a J-shaped pattern through distinct mechanisms.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Food Science and Nutrition School of Pharmaceutical Sciences University of São Paulo (USP)Department of Fundamental Chemistry University of São Paulo (USP)Food Research Center (FoRC)Department of Morphology Institute of Biosciences of Botucatu Sao Paulo State University (UNESP), São PauloDepartment of Morphology Institute of Biosciences of Botucatu Sao Paulo State University (UNESP), São PauloFAPESP: 11/23259-4FAPESP: 2013/04960-9CNPq: 307910/2016-4Universidade de São Paulo (USP)Food Research Center (FoRC)Universidade Estadual Paulista (Unesp)da Cruz, Raquel SantanaAndrade, Fabia de OliveiraCarioni, Vivian Montes de OcaRosim, Mariana PapaléoMiranda, Mayara Lilian PaulinoFontelles, Camile Castilhode Oliveira, Pedro VitorianoBarbisan, Luis Fernando [UNESP]Castro, Inar AlvesOng, Thomas Prates2019-10-06T16:47:50Z2019-10-06T16:47:50Z2019-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.fct.2019.110813Food and Chemical Toxicology, v. 134.1873-63510278-6915http://hdl.handle.net/11449/18965810.1016/j.fct.2019.1108132-s2.0-850722451073278528112652257Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood and Chemical Toxicologyinfo:eu-repo/semantics/openAccess2021-10-22T21:09:48Zoai:repositorio.unesp.br:11449/189658Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:12:59.133724Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
title |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
spellingShingle |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms da Cruz, Raquel Santana Breast cancer Fetal programming Gestation Maternal nutrition Zinc |
title_short |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
title_full |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
title_fullStr |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
title_full_unstemmed |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
title_sort |
Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms |
author |
da Cruz, Raquel Santana |
author_facet |
da Cruz, Raquel Santana Andrade, Fabia de Oliveira Carioni, Vivian Montes de Oca Rosim, Mariana Papaléo Miranda, Mayara Lilian Paulino Fontelles, Camile Castilho de Oliveira, Pedro Vitoriano Barbisan, Luis Fernando [UNESP] Castro, Inar Alves Ong, Thomas Prates |
author_role |
author |
author2 |
Andrade, Fabia de Oliveira Carioni, Vivian Montes de Oca Rosim, Mariana Papaléo Miranda, Mayara Lilian Paulino Fontelles, Camile Castilho de Oliveira, Pedro Vitoriano Barbisan, Luis Fernando [UNESP] Castro, Inar Alves Ong, Thomas Prates |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Food Research Center (FoRC) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
da Cruz, Raquel Santana Andrade, Fabia de Oliveira Carioni, Vivian Montes de Oca Rosim, Mariana Papaléo Miranda, Mayara Lilian Paulino Fontelles, Camile Castilho de Oliveira, Pedro Vitoriano Barbisan, Luis Fernando [UNESP] Castro, Inar Alves Ong, Thomas Prates |
dc.subject.por.fl_str_mv |
Breast cancer Fetal programming Gestation Maternal nutrition Zinc |
topic |
Breast cancer Fetal programming Gestation Maternal nutrition Zinc |
description |
Zinc is required for fetal development and is involved in key processes associated with breast carcinogenesis. We evaluated whether maternal zinc deficiency or supplementation during gestation influences female offspring susceptibility to breast cancer in adulthood. C57BL/6 mice consumed during gestation control (30 p.p.m. zinc), zinc-deficient (8 p.p.m) or zinc-supplemented (45 p.p.m.) diets. Maternal zinc supplementation increased in female mice offspring the incidence of chemically-induced mammary adenocarcinomas that were heavier, compared to control group. This was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and Rassf1, Zfp382 and Stat3 expression in mammary glands, as well as increased zinc status. Although maternal zinc deficiency did not alter the incidence of these lesions, it also induced heavier mammary adenocarcinomas, compared to control group. These effects were accompanied by a decreased number of terminal end buds, increased proto-oncogenes c-Myc and Lmo4 expression and H3K9Me3 and H4K20Me3 epigenetic marks in mammary glands of offspring, and decreased zinc status and increased levels of oxidative marker malondialdehyde. The data suggest that both maternal zinc deficiency and supplementation during gestation programmed increased breast cancer susceptibility in adult mice offspring following a J-shaped pattern through distinct mechanisms. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:47:50Z 2019-10-06T16:47:50Z 2019-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fct.2019.110813 Food and Chemical Toxicology, v. 134. 1873-6351 0278-6915 http://hdl.handle.net/11449/189658 10.1016/j.fct.2019.110813 2-s2.0-85072245107 3278528112652257 |
url |
http://dx.doi.org/10.1016/j.fct.2019.110813 http://hdl.handle.net/11449/189658 |
identifier_str_mv |
Food and Chemical Toxicology, v. 134. 1873-6351 0278-6915 10.1016/j.fct.2019.110813 2-s2.0-85072245107 3278528112652257 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food and Chemical Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128774270615552 |