Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Dayane C. [UNESP]
Data de Publicação: 2021
Outros Autores: Russo, Helena M. [UNESP], Fraige, Karina [UNESP], Zeraik, Maria L., Nogueira, Cláudio R., da Silva, Patrícia B., Codo, Ana C. [UNESP], Calixto, Giovana M.F. [UNESP], de Medeiros, Alexandra I. [UNESP], Chorilli, Marlus [UNESP], Bolzani, Vanderlan S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.21577/0103-5053.20200230
http://hdl.handle.net/11449/207441
Resumo: Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues.
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spelling Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value CompoundsBiflavanonesBioactivitiesClusiaceaeLiquid-crystalline systemPlatonia insignisPlatonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Núcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Departamento de Química Orgânica Instituto de Química Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Laboratório de Fitoquímica e Biomoléculas (LabFitoBio) Departamento de Química Universidade Estadual de Londrina (UEL)Faculdade de Ciências Exatas e Tecnologia (FACET) Universidade Federal da Grande Dourados (UFGD)Departamento de Genética e Morfologia Universidade de Brasília (UnB)Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Núcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Departamento de Química Orgânica Instituto de Química Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp)CNPq: 142014/2018-4CNPq: 159735/2017-3FAPESP: 2013/07600-3CNPq: 2014/465637-0FAPESP: 2014/50926-0FAPESP: 2016/16970-7FAPESP: 2017/18807-9FAPESP: 2017/19870-6Universidade Estadual Paulista (Unesp)Universidade Estadual de Londrina (UEL)Universidade Federal da Grande Dourados (UFGD)Universidade de Brasília (UnB)Ribeiro, Dayane C. [UNESP]Russo, Helena M. [UNESP]Fraige, Karina [UNESP]Zeraik, Maria L.Nogueira, Cláudio R.da Silva, Patrícia B.Codo, Ana C. [UNESP]Calixto, Giovana M.F. [UNESP]de Medeiros, Alexandra I. [UNESP]Chorilli, Marlus [UNESP]Bolzani, Vanderlan S. [UNESP]2021-06-25T10:55:13Z2021-06-25T10:55:13Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article786-799application/pdfhttp://dx.doi.org/10.21577/0103-5053.20200230Journal of the Brazilian Chemical Society, v. 32, n. 4, p. 786-799, 2021.1678-47900103-5053http://hdl.handle.net/11449/20744110.21577/0103-5053.20200230S0103-505320210004007862-s2.0-85102427367S0103-50532021000400786.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Societyinfo:eu-repo/semantics/openAccess2024-06-24T13:46:11Zoai:repositorio.unesp.br:11449/207441Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:35:22.490571Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
title Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
spellingShingle Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
Ribeiro, Dayane C. [UNESP]
Biflavanones
Bioactivities
Clusiaceae
Liquid-crystalline system
Platonia insignis
title_short Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
title_full Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
title_fullStr Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
title_full_unstemmed Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
title_sort Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
author Ribeiro, Dayane C. [UNESP]
author_facet Ribeiro, Dayane C. [UNESP]
Russo, Helena M. [UNESP]
Fraige, Karina [UNESP]
Zeraik, Maria L.
Nogueira, Cláudio R.
da Silva, Patrícia B.
Codo, Ana C. [UNESP]
Calixto, Giovana M.F. [UNESP]
de Medeiros, Alexandra I. [UNESP]
Chorilli, Marlus [UNESP]
Bolzani, Vanderlan S. [UNESP]
author_role author
author2 Russo, Helena M. [UNESP]
Fraige, Karina [UNESP]
Zeraik, Maria L.
Nogueira, Cláudio R.
da Silva, Patrícia B.
Codo, Ana C. [UNESP]
Calixto, Giovana M.F. [UNESP]
de Medeiros, Alexandra I. [UNESP]
Chorilli, Marlus [UNESP]
Bolzani, Vanderlan S. [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Londrina (UEL)
Universidade Federal da Grande Dourados (UFGD)
Universidade de Brasília (UnB)
dc.contributor.author.fl_str_mv Ribeiro, Dayane C. [UNESP]
Russo, Helena M. [UNESP]
Fraige, Karina [UNESP]
Zeraik, Maria L.
Nogueira, Cláudio R.
da Silva, Patrícia B.
Codo, Ana C. [UNESP]
Calixto, Giovana M.F. [UNESP]
de Medeiros, Alexandra I. [UNESP]
Chorilli, Marlus [UNESP]
Bolzani, Vanderlan S. [UNESP]
dc.subject.por.fl_str_mv Biflavanones
Bioactivities
Clusiaceae
Liquid-crystalline system
Platonia insignis
topic Biflavanones
Bioactivities
Clusiaceae
Liquid-crystalline system
Platonia insignis
description Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:55:13Z
2021-06-25T10:55:13Z
2021-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.21577/0103-5053.20200230
Journal of the Brazilian Chemical Society, v. 32, n. 4, p. 786-799, 2021.
1678-4790
0103-5053
http://hdl.handle.net/11449/207441
10.21577/0103-5053.20200230
S0103-50532021000400786
2-s2.0-85102427367
S0103-50532021000400786.pdf
url http://dx.doi.org/10.21577/0103-5053.20200230
http://hdl.handle.net/11449/207441
identifier_str_mv Journal of the Brazilian Chemical Society, v. 32, n. 4, p. 786-799, 2021.
1678-4790
0103-5053
10.21577/0103-5053.20200230
S0103-50532021000400786
2-s2.0-85102427367
S0103-50532021000400786.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the Brazilian Chemical Society
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 786-799
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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