Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fnins.2022.878927 http://hdl.handle.net/11449/240123 |
Resumo: | The insular cortex (IC) has been described as a part of the central network implicated in the integration and processing of limbic information, being related to the behavioral and physiological responses to stressful events. Besides, a site-specific control of physiological functions has been reported along the rostrocaudal axis of the IC. However, a functional topography of the IC in the regulation of stress responses has never been reported. Therefore, this study aimed to investigate the impact of acute restraint stress in neuronal activation at different sites along the rostrocaudal axis of the IC. Furthermore, we evaluated the involvement of IC rostrocaudal subregions in the cardiovascular responses to acute restraint stress. We observed that an acute session of restraint stress increased the number of Fos-immunoreactive cells in the rostral posterior region of the IC, while fewer activated cells were identified in the anterior and caudal posterior regions. Bilateral injection of the non-selective synaptic inhibitor CoCl2 into the anterior region of the IC did not affect the blood pressure and heart rate increases and the sympathetically mediated cutaneous vasoconstriction to acute restraint stress. However, synaptic ablation of the rostral posterior IC decreased the restraint-evoked arterial pressure increase, whereas tachycardia was reduced in animals in which the caudal posterior IC was inhibited. Taken together, these pieces of evidence indicate a site-specific regulation of cardiovascular stress response along the rostrocaudal axis of the IC. |
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Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Ratscardiovascular functionFosprefrontal cortexrestraint stresssympathetic activitytopographyThe insular cortex (IC) has been described as a part of the central network implicated in the integration and processing of limbic information, being related to the behavioral and physiological responses to stressful events. Besides, a site-specific control of physiological functions has been reported along the rostrocaudal axis of the IC. However, a functional topography of the IC in the regulation of stress responses has never been reported. Therefore, this study aimed to investigate the impact of acute restraint stress in neuronal activation at different sites along the rostrocaudal axis of the IC. Furthermore, we evaluated the involvement of IC rostrocaudal subregions in the cardiovascular responses to acute restraint stress. We observed that an acute session of restraint stress increased the number of Fos-immunoreactive cells in the rostral posterior region of the IC, while fewer activated cells were identified in the anterior and caudal posterior regions. Bilateral injection of the non-selective synaptic inhibitor CoCl2 into the anterior region of the IC did not affect the blood pressure and heart rate increases and the sympathetically mediated cutaneous vasoconstriction to acute restraint stress. However, synaptic ablation of the rostral posterior IC decreased the restraint-evoked arterial pressure increase, whereas tachycardia was reduced in animals in which the caudal posterior IC was inhibited. Taken together, these pieces of evidence indicate a site-specific regulation of cardiovascular stress response along the rostrocaudal axis of the IC.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Laboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)Laboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2017/19249-0FAPESP: 2019/24478-3CNPq: 304108/2018-9CNPq: 431339/2018-0CAPES: code 001Universidade Estadual Paulista (UNESP)Tomeo, Rodrigo A. [UNESP]Gomes-de-Souza, Lucas [UNESP]Benini, Ricardo [UNESP]Reis-Silva, Lilian L. [UNESP]Crestani, Carlos C. [UNESP]2023-03-01T20:02:32Z2023-03-01T20:02:32Z2022-05-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fnins.2022.878927Frontiers in Neuroscience, v. 16.1662-453X1662-4548http://hdl.handle.net/11449/24012310.3389/fnins.2022.8789272-s2.0-85130715637Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Neuroscienceinfo:eu-repo/semantics/openAccess2023-03-01T20:02:32Zoai:repositorio.unesp.br:11449/240123Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:33:15.763650Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
title |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
spellingShingle |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats Tomeo, Rodrigo A. [UNESP] cardiovascular function Fos prefrontal cortex restraint stress sympathetic activity topography |
title_short |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
title_full |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
title_fullStr |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
title_full_unstemmed |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
title_sort |
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats |
author |
Tomeo, Rodrigo A. [UNESP] |
author_facet |
Tomeo, Rodrigo A. [UNESP] Gomes-de-Souza, Lucas [UNESP] Benini, Ricardo [UNESP] Reis-Silva, Lilian L. [UNESP] Crestani, Carlos C. [UNESP] |
author_role |
author |
author2 |
Gomes-de-Souza, Lucas [UNESP] Benini, Ricardo [UNESP] Reis-Silva, Lilian L. [UNESP] Crestani, Carlos C. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Tomeo, Rodrigo A. [UNESP] Gomes-de-Souza, Lucas [UNESP] Benini, Ricardo [UNESP] Reis-Silva, Lilian L. [UNESP] Crestani, Carlos C. [UNESP] |
dc.subject.por.fl_str_mv |
cardiovascular function Fos prefrontal cortex restraint stress sympathetic activity topography |
topic |
cardiovascular function Fos prefrontal cortex restraint stress sympathetic activity topography |
description |
The insular cortex (IC) has been described as a part of the central network implicated in the integration and processing of limbic information, being related to the behavioral and physiological responses to stressful events. Besides, a site-specific control of physiological functions has been reported along the rostrocaudal axis of the IC. However, a functional topography of the IC in the regulation of stress responses has never been reported. Therefore, this study aimed to investigate the impact of acute restraint stress in neuronal activation at different sites along the rostrocaudal axis of the IC. Furthermore, we evaluated the involvement of IC rostrocaudal subregions in the cardiovascular responses to acute restraint stress. We observed that an acute session of restraint stress increased the number of Fos-immunoreactive cells in the rostral posterior region of the IC, while fewer activated cells were identified in the anterior and caudal posterior regions. Bilateral injection of the non-selective synaptic inhibitor CoCl2 into the anterior region of the IC did not affect the blood pressure and heart rate increases and the sympathetically mediated cutaneous vasoconstriction to acute restraint stress. However, synaptic ablation of the rostral posterior IC decreased the restraint-evoked arterial pressure increase, whereas tachycardia was reduced in animals in which the caudal posterior IC was inhibited. Taken together, these pieces of evidence indicate a site-specific regulation of cardiovascular stress response along the rostrocaudal axis of the IC. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-10 2023-03-01T20:02:32Z 2023-03-01T20:02:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fnins.2022.878927 Frontiers in Neuroscience, v. 16. 1662-453X 1662-4548 http://hdl.handle.net/11449/240123 10.3389/fnins.2022.878927 2-s2.0-85130715637 |
url |
http://dx.doi.org/10.3389/fnins.2022.878927 http://hdl.handle.net/11449/240123 |
identifier_str_mv |
Frontiers in Neuroscience, v. 16. 1662-453X 1662-4548 10.3389/fnins.2022.878927 2-s2.0-85130715637 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Neuroscience |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128670312693760 |