Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10709-016-9894-1 http://hdl.handle.net/11449/172711 |
Resumo: | Ancestry information can be useful in investigations of diseases with a genetic or infectious background. As the Brazilian population is highly admixed physical traits tend to be poor indicators of ancestry. The assessment of ancestry by ancestry informative markers (AIMs) can exclude the subjectivity of self-declared ethnicity and reported family origin. We aimed to evaluate the reliability of self-reported ethnicity or reported family origin as indicators of genomic ancestry in a female population from the Southeast of Brazil. Two cohorts were included: 404 women asked to self-report their ethnicity (Pop1) and 234 women asked to report their family’s origin (Pop2). Identification of AIMs was performed using a panel of 61 markers and results were plotted against parental populations—Amerindian, Western European and Sub-Saharan African—using Structure v2.3.4. In Pop1 57.4 % of women self-reported as white, 34.6 % as brown and 8.0 % as black. Median global European, Amerindian and African contributions were 66.8, 12.6 and 16.6 %. In Pop2, 66.4 % of women declared European origin, 23.9 % African origin and 26.9 % Amerindian. Median global European, Amerindian and African contributions were 80.8, 7.3 and 7.6 %, respectively. Only 31.0 and 21.0 % of the global variation in African and European contributions, respectively, could be explained by self-reported ethnicity and reported family origin only accounted for 20.0 and 5.0 % of the variations observed in African and European ancestries, respectively. Amerindian ancestry did not influence self-reported ethnicity or declared family origin. Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry in these Brazilian populations. |
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Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestryAncestry informative markersEthnicityGeneticsHealthSoutheastern Brazilian populationAncestry information can be useful in investigations of diseases with a genetic or infectious background. As the Brazilian population is highly admixed physical traits tend to be poor indicators of ancestry. The assessment of ancestry by ancestry informative markers (AIMs) can exclude the subjectivity of self-declared ethnicity and reported family origin. We aimed to evaluate the reliability of self-reported ethnicity or reported family origin as indicators of genomic ancestry in a female population from the Southeast of Brazil. Two cohorts were included: 404 women asked to self-report their ethnicity (Pop1) and 234 women asked to report their family’s origin (Pop2). Identification of AIMs was performed using a panel of 61 markers and results were plotted against parental populations—Amerindian, Western European and Sub-Saharan African—using Structure v2.3.4. In Pop1 57.4 % of women self-reported as white, 34.6 % as brown and 8.0 % as black. Median global European, Amerindian and African contributions were 66.8, 12.6 and 16.6 %. In Pop2, 66.4 % of women declared European origin, 23.9 % African origin and 26.9 % Amerindian. Median global European, Amerindian and African contributions were 80.8, 7.3 and 7.6 %, respectively. Only 31.0 and 21.0 % of the global variation in African and European contributions, respectively, could be explained by self-reported ethnicity and reported family origin only accounted for 20.0 and 5.0 % of the variations observed in African and European ancestries, respectively. Amerindian ancestry did not influence self-reported ethnicity or declared family origin. Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry in these Brazilian populations.Department of Pathology Botucatu Medical School São Paulo State University – UNESP, Distrito de Rubião JúniorDepatment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University – UNESPDepatment of Genetics Biological Sciences Institute Pará Federal University – UFPADepartment of Obstetrics and Gynecology Weill Cornell Medical CollegeDepartment of Pathology Botucatu Medical School São Paulo State University – UNESP, Distrito de Rubião JúniorDepatment of Dermatology and Radiotherapy Botucatu Medical School São Paulo State University – UNESPUniversidade Estadual Paulista (Unesp)Universidade Federal do Pará (UFPA)Weill Cornell Medical Collegede Ramos, Bruna Ribeiro Andrade [UNESP]D’Elia, Maria Paula Barbieri [UNESP]Amador, Marcos Antônio TrindadeSantos, Ney Pereira CarneiroSantos, Sidney Emanuel Batistada Cruz Castelli, Erick [UNESP]Witkin, Steven S.Miot, Hélio Amante [UNESP]Miot, Luciane Donida Bartoli [UNESP]da Silva, Márcia Guimarães [UNESP]2018-12-11T17:01:52Z2018-12-11T17:01:52Z2016-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article259-265application/pdfhttp://dx.doi.org/10.1007/s10709-016-9894-1Genetica, v. 144, n. 3, p. 259-265, 2016.1573-68570016-6707http://hdl.handle.net/11449/17271110.1007/s10709-016-9894-12-s2.0-849612075592-s2.0-84961207559.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetica0,6490,649info:eu-repo/semantics/openAccess2024-09-03T13:15:38Zoai:repositorio.unesp.br:11449/172711Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
title |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
spellingShingle |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry de Ramos, Bruna Ribeiro Andrade [UNESP] Ancestry informative markers Ethnicity Genetics Health Southeastern Brazilian population |
title_short |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
title_full |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
title_fullStr |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
title_full_unstemmed |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
title_sort |
Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry |
author |
de Ramos, Bruna Ribeiro Andrade [UNESP] |
author_facet |
de Ramos, Bruna Ribeiro Andrade [UNESP] D’Elia, Maria Paula Barbieri [UNESP] Amador, Marcos Antônio Trindade Santos, Ney Pereira Carneiro Santos, Sidney Emanuel Batista da Cruz Castelli, Erick [UNESP] Witkin, Steven S. Miot, Hélio Amante [UNESP] Miot, Luciane Donida Bartoli [UNESP] da Silva, Márcia Guimarães [UNESP] |
author_role |
author |
author2 |
D’Elia, Maria Paula Barbieri [UNESP] Amador, Marcos Antônio Trindade Santos, Ney Pereira Carneiro Santos, Sidney Emanuel Batista da Cruz Castelli, Erick [UNESP] Witkin, Steven S. Miot, Hélio Amante [UNESP] Miot, Luciane Donida Bartoli [UNESP] da Silva, Márcia Guimarães [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Pará (UFPA) Weill Cornell Medical College |
dc.contributor.author.fl_str_mv |
de Ramos, Bruna Ribeiro Andrade [UNESP] D’Elia, Maria Paula Barbieri [UNESP] Amador, Marcos Antônio Trindade Santos, Ney Pereira Carneiro Santos, Sidney Emanuel Batista da Cruz Castelli, Erick [UNESP] Witkin, Steven S. Miot, Hélio Amante [UNESP] Miot, Luciane Donida Bartoli [UNESP] da Silva, Márcia Guimarães [UNESP] |
dc.subject.por.fl_str_mv |
Ancestry informative markers Ethnicity Genetics Health Southeastern Brazilian population |
topic |
Ancestry informative markers Ethnicity Genetics Health Southeastern Brazilian population |
description |
Ancestry information can be useful in investigations of diseases with a genetic or infectious background. As the Brazilian population is highly admixed physical traits tend to be poor indicators of ancestry. The assessment of ancestry by ancestry informative markers (AIMs) can exclude the subjectivity of self-declared ethnicity and reported family origin. We aimed to evaluate the reliability of self-reported ethnicity or reported family origin as indicators of genomic ancestry in a female population from the Southeast of Brazil. Two cohorts were included: 404 women asked to self-report their ethnicity (Pop1) and 234 women asked to report their family’s origin (Pop2). Identification of AIMs was performed using a panel of 61 markers and results were plotted against parental populations—Amerindian, Western European and Sub-Saharan African—using Structure v2.3.4. In Pop1 57.4 % of women self-reported as white, 34.6 % as brown and 8.0 % as black. Median global European, Amerindian and African contributions were 66.8, 12.6 and 16.6 %. In Pop2, 66.4 % of women declared European origin, 23.9 % African origin and 26.9 % Amerindian. Median global European, Amerindian and African contributions were 80.8, 7.3 and 7.6 %, respectively. Only 31.0 and 21.0 % of the global variation in African and European contributions, respectively, could be explained by self-reported ethnicity and reported family origin only accounted for 20.0 and 5.0 % of the variations observed in African and European ancestries, respectively. Amerindian ancestry did not influence self-reported ethnicity or declared family origin. Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry in these Brazilian populations. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 2018-12-11T17:01:52Z 2018-12-11T17:01:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10709-016-9894-1 Genetica, v. 144, n. 3, p. 259-265, 2016. 1573-6857 0016-6707 http://hdl.handle.net/11449/172711 10.1007/s10709-016-9894-1 2-s2.0-84961207559 2-s2.0-84961207559.pdf |
url |
http://dx.doi.org/10.1007/s10709-016-9894-1 http://hdl.handle.net/11449/172711 |
identifier_str_mv |
Genetica, v. 144, n. 3, p. 259-265, 2016. 1573-6857 0016-6707 10.1007/s10709-016-9894-1 2-s2.0-84961207559 2-s2.0-84961207559.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetica 0,649 0,649 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
259-265 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021397041250304 |