Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/1097-0142(19950415)75:8<2123 http://hdl.handle.net/11449/224002 |
Resumo: | Background. Ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly since the advent of mammography. However, the natural history of these lesions remains uncertain. Ductal carcinoma in situ of the breast does not represent a single entity but a heterogeneous group with histologic and clinical differences. The histologic subtype of DCIS seems to have an influence on its biologic behavior, but there are few studies correlating subtype with biologic markers. Methods. The authors studied a consecutive series of 40 cases of DCIS and after its histologic categorization verified its relationship with ploidy using image analysis and analyzing estrogen receptor (ER), progesterone receptor (PR), p53 and c‐erbB‐2 expression using immunohistochemistry. Results. The three groups proposed according to the grade of malignancy were correlated significantly with some of the additional parameters studied, including aneuploidy and c‐erbB‐2 expression. Aneuploidy was detected in 77.5% of cases of DCIS mainly in high and intermediate grade subtypes (100% and 80% vs. 35.7% in low grade) whereas immunoreactivity for c‐erbB‐2 was detected in 45% of cases of DCIS mainly in the high grade group. Expression of ER and PR were observed frequently in this study (63.9% and 65.7% respectively), but without correlation with the histologic subtype of DCIS, although we found a somewhat significant association between high grade DCIS and lack of ER. p53 protein expression was detected in 36.8% of these cases, but no relationship between this expression and histologic subtype or grading of DCIS was found. Conclusions. These results provide further evidence for the morphologic and biologic heterogeneity of DCIS. Besides histologic classification and nuclear grading, some biologic markers such as aneuploidy and c‐erbB‐2 expression constitute additional criteria of high grade of malignancy. Copyright © 1995 American Cancer Society |
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Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 proteinbreast ductal carcinoma in situ (DCIS)c‐erbB‐2 expressionDCIS subtypeshormone receptorsp53ploidyBackground. Ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly since the advent of mammography. However, the natural history of these lesions remains uncertain. Ductal carcinoma in situ of the breast does not represent a single entity but a heterogeneous group with histologic and clinical differences. The histologic subtype of DCIS seems to have an influence on its biologic behavior, but there are few studies correlating subtype with biologic markers. Methods. The authors studied a consecutive series of 40 cases of DCIS and after its histologic categorization verified its relationship with ploidy using image analysis and analyzing estrogen receptor (ER), progesterone receptor (PR), p53 and c‐erbB‐2 expression using immunohistochemistry. Results. The three groups proposed according to the grade of malignancy were correlated significantly with some of the additional parameters studied, including aneuploidy and c‐erbB‐2 expression. Aneuploidy was detected in 77.5% of cases of DCIS mainly in high and intermediate grade subtypes (100% and 80% vs. 35.7% in low grade) whereas immunoreactivity for c‐erbB‐2 was detected in 45% of cases of DCIS mainly in the high grade group. Expression of ER and PR were observed frequently in this study (63.9% and 65.7% respectively), but without correlation with the histologic subtype of DCIS, although we found a somewhat significant association between high grade DCIS and lack of ER. p53 protein expression was detected in 36.8% of these cases, but no relationship between this expression and histologic subtype or grading of DCIS was found. Conclusions. These results provide further evidence for the morphologic and biologic heterogeneity of DCIS. Besides histologic classification and nuclear grading, some biologic markers such as aneuploidy and c‐erbB‐2 expression constitute additional criteria of high grade of malignancy. Copyright © 1995 American Cancer SocietyDepartment of Pathology Cancer Institute, PortoDepartment of Epidemiology Cancer Institute, PortoDepartment of Surgery Cancer Institute, PortoDepartment of Pathology Botucatu School of Medicine Universidade Estadual Paulista, Botucatu, Sã PauloUnit of Molecular Pathology IPATIMUP Porto Medical School, PortoUnit of Molecular Pathology IPATIMUP, PortoDepartment of Pathology Botucatu School of Medicine Universidade Estadual Paulista, Botucatu, Sã PauloCancer InstituteUniversidade Estadual Paulista (UNESP)Porto Medical SchoolIPATIMUPLeal, Conceição B.Schmitt, Fernando C. [UNESP]Bento, Maria J.Maia, Nuno C.Lopes, Carlos S.2022-04-28T19:54:16Z2022-04-28T19:54:16Z1995-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2123-2131http://dx.doi.org/10.1002/1097-0142(19950415)75:8<2123Cancer, v. 75, n. 8, p. 2123-2131, 1995.1097-01420008-543Xhttp://hdl.handle.net/11449/22400210.1002/1097-0142(19950415)75:8<21232-s2.0-0028952065Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCancerinfo:eu-repo/semantics/openAccess2024-09-03T13:18:44Zoai:repositorio.unesp.br:11449/224002Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:44Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
title |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
spellingShingle |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein Leal, Conceição B. breast ductal carcinoma in situ (DCIS) c‐erbB‐2 expression DCIS subtypes hormone receptors p53 ploidy |
title_short |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
title_full |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
title_fullStr |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
title_full_unstemmed |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
title_sort |
Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein |
author |
Leal, Conceição B. |
author_facet |
Leal, Conceição B. Schmitt, Fernando C. [UNESP] Bento, Maria J. Maia, Nuno C. Lopes, Carlos S. |
author_role |
author |
author2 |
Schmitt, Fernando C. [UNESP] Bento, Maria J. Maia, Nuno C. Lopes, Carlos S. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Cancer Institute Universidade Estadual Paulista (UNESP) Porto Medical School IPATIMUP |
dc.contributor.author.fl_str_mv |
Leal, Conceição B. Schmitt, Fernando C. [UNESP] Bento, Maria J. Maia, Nuno C. Lopes, Carlos S. |
dc.subject.por.fl_str_mv |
breast ductal carcinoma in situ (DCIS) c‐erbB‐2 expression DCIS subtypes hormone receptors p53 ploidy |
topic |
breast ductal carcinoma in situ (DCIS) c‐erbB‐2 expression DCIS subtypes hormone receptors p53 ploidy |
description |
Background. Ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly since the advent of mammography. However, the natural history of these lesions remains uncertain. Ductal carcinoma in situ of the breast does not represent a single entity but a heterogeneous group with histologic and clinical differences. The histologic subtype of DCIS seems to have an influence on its biologic behavior, but there are few studies correlating subtype with biologic markers. Methods. The authors studied a consecutive series of 40 cases of DCIS and after its histologic categorization verified its relationship with ploidy using image analysis and analyzing estrogen receptor (ER), progesterone receptor (PR), p53 and c‐erbB‐2 expression using immunohistochemistry. Results. The three groups proposed according to the grade of malignancy were correlated significantly with some of the additional parameters studied, including aneuploidy and c‐erbB‐2 expression. Aneuploidy was detected in 77.5% of cases of DCIS mainly in high and intermediate grade subtypes (100% and 80% vs. 35.7% in low grade) whereas immunoreactivity for c‐erbB‐2 was detected in 45% of cases of DCIS mainly in the high grade group. Expression of ER and PR were observed frequently in this study (63.9% and 65.7% respectively), but without correlation with the histologic subtype of DCIS, although we found a somewhat significant association between high grade DCIS and lack of ER. p53 protein expression was detected in 36.8% of these cases, but no relationship between this expression and histologic subtype or grading of DCIS was found. Conclusions. These results provide further evidence for the morphologic and biologic heterogeneity of DCIS. Besides histologic classification and nuclear grading, some biologic markers such as aneuploidy and c‐erbB‐2 expression constitute additional criteria of high grade of malignancy. Copyright © 1995 American Cancer Society |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-01-01 2022-04-28T19:54:16Z 2022-04-28T19:54:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/1097-0142(19950415)75:8<2123 Cancer, v. 75, n. 8, p. 2123-2131, 1995. 1097-0142 0008-543X http://hdl.handle.net/11449/224002 10.1002/1097-0142(19950415)75:8<2123 2-s2.0-0028952065 |
url |
http://dx.doi.org/10.1002/1097-0142(19950415)75:8<2123 http://hdl.handle.net/11449/224002 |
identifier_str_mv |
Cancer, v. 75, n. 8, p. 2123-2131, 1995. 1097-0142 0008-543X 10.1002/1097-0142(19950415)75:8<2123 2-s2.0-0028952065 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cancer |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2123-2131 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021427155304448 |