Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.sajb.2019.10.011 http://hdl.handle.net/11449/199745 |
Resumo: | The phytochemical profile, formulations (nanoparticles and gel), moisturizing and antioxidant potential of a hydroalcoholic fraction of Moringa oleifera leaves (HFM) were determined. These were obtained through the application of eco-friendly strategies of cultivation and processing. The HFM phytochemical analysis by ESI-IT-MSn showed the presence of seven compounds (flavonoids and phenolic acids). The viscosity, pH and particle size of HFM formulations ensure the suitability for topical application. Antioxidant activity was determined by inhibition of lipid peroxidation and ferric thiocyanate in vitro; it was confirmed that HFM and in formulations showed a significant inhibition of oxidation. In relation to the in vitro skin biophysical evaluation for topical formulations of HFM, water content, lipids and trans-epidermal water loss on the skin were favored with the presence of HFM. In addition, skin pH was not been modified. Our results emphasize the moisturizing and antioxidant potential of the moringa-formulation as a new skin drug delivery system. |
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Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniquesESI-IT-MSnGelHydroalcoholic extractMoringa oleíferaNanoparticlesProtected croppingSkin bioengineering techniquesSPEThe phytochemical profile, formulations (nanoparticles and gel), moisturizing and antioxidant potential of a hydroalcoholic fraction of Moringa oleifera leaves (HFM) were determined. These were obtained through the application of eco-friendly strategies of cultivation and processing. The HFM phytochemical analysis by ESI-IT-MSn showed the presence of seven compounds (flavonoids and phenolic acids). The viscosity, pH and particle size of HFM formulations ensure the suitability for topical application. Antioxidant activity was determined by inhibition of lipid peroxidation and ferric thiocyanate in vitro; it was confirmed that HFM and in formulations showed a significant inhibition of oxidation. In relation to the in vitro skin biophysical evaluation for topical formulations of HFM, water content, lipids and trans-epidermal water loss on the skin were favored with the presence of HFM. In addition, skin pH was not been modified. Our results emphasize the moisturizing and antioxidant potential of the moringa-formulation as a new skin drug delivery system.Consejo Nacional de Ciencia y TecnologíaDepartamento de Química Analítica Facultad de Medicina Universidad Autónoma de Nuevo León, Av. Fco. I. Madero y Dr. E. Aguirre Pequeño s/nDepartamento de Química Analítica Facultad de Ciencias Biológicas Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/nInstituto de Biotecnología. Universidad del Papaloapan, Av. Circuito Central No. 200 Col. Parque Industrial. TuxtepecInstituto de Biociências – Câmpus do litoral Paulista UNESP – Universidade Estadual Paulista, Praça Dom Infante Henrique s/n, Parque Bitaru CEP 11330-900, São VicenteCátedras CONACYT-UANLCátedras CONACYT-UNPAInstituto de Biociências – Câmpus do litoral Paulista UNESP – Universidade Estadual Paulista, Praça Dom Infante Henrique s/n, Parque Bitaru CEP 11330-900, São VicenteConsejo Nacional de Ciencia y Tecnología: -Consejo Nacional de Ciencia y Tecnología: 284813Consejo Nacional de Ciencia y Tecnología: CB/2016Universidad Autónoma de Nuevo LeónInstituto de Biotecnología. Universidad del PapaloapanUniversidade Estadual Paulista (Unesp)Cátedras CONACYT-UANLCátedras CONACYT-UNPAÁlvarez-Román, R.Silva-Flores, P. G.Galindo-Rodríguez, S. A.Huerta-Heredia, A. A.Vilegas, W. [UNESP]Paniagua-Vega, D.2020-12-12T01:48:12Z2020-12-12T01:48:12Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article404-411http://dx.doi.org/10.1016/j.sajb.2019.10.011South African Journal of Botany, v. 129, p. 404-411.0254-6299http://hdl.handle.net/11449/19974510.1016/j.sajb.2019.10.0112-s2.0-85075871834Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSouth African Journal of Botanyinfo:eu-repo/semantics/openAccess2021-10-23T09:26:34Zoai:repositorio.unesp.br:11449/199745Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:06:48.981249Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
title |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
spellingShingle |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques Álvarez-Román, R. ESI-IT-MSn Gel Hydroalcoholic extract Moringa oleífera Nanoparticles Protected cropping Skin bioengineering techniques SPE |
title_short |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
title_full |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
title_fullStr |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
title_full_unstemmed |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
title_sort |
Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques |
author |
Álvarez-Román, R. |
author_facet |
Álvarez-Román, R. Silva-Flores, P. G. Galindo-Rodríguez, S. A. Huerta-Heredia, A. A. Vilegas, W. [UNESP] Paniagua-Vega, D. |
author_role |
author |
author2 |
Silva-Flores, P. G. Galindo-Rodríguez, S. A. Huerta-Heredia, A. A. Vilegas, W. [UNESP] Paniagua-Vega, D. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidad Autónoma de Nuevo León Instituto de Biotecnología. Universidad del Papaloapan Universidade Estadual Paulista (Unesp) Cátedras CONACYT-UANL Cátedras CONACYT-UNPA |
dc.contributor.author.fl_str_mv |
Álvarez-Román, R. Silva-Flores, P. G. Galindo-Rodríguez, S. A. Huerta-Heredia, A. A. Vilegas, W. [UNESP] Paniagua-Vega, D. |
dc.subject.por.fl_str_mv |
ESI-IT-MSn Gel Hydroalcoholic extract Moringa oleífera Nanoparticles Protected cropping Skin bioengineering techniques SPE |
topic |
ESI-IT-MSn Gel Hydroalcoholic extract Moringa oleífera Nanoparticles Protected cropping Skin bioengineering techniques SPE |
description |
The phytochemical profile, formulations (nanoparticles and gel), moisturizing and antioxidant potential of a hydroalcoholic fraction of Moringa oleifera leaves (HFM) were determined. These were obtained through the application of eco-friendly strategies of cultivation and processing. The HFM phytochemical analysis by ESI-IT-MSn showed the presence of seven compounds (flavonoids and phenolic acids). The viscosity, pH and particle size of HFM formulations ensure the suitability for topical application. Antioxidant activity was determined by inhibition of lipid peroxidation and ferric thiocyanate in vitro; it was confirmed that HFM and in formulations showed a significant inhibition of oxidation. In relation to the in vitro skin biophysical evaluation for topical formulations of HFM, water content, lipids and trans-epidermal water loss on the skin were favored with the presence of HFM. In addition, skin pH was not been modified. Our results emphasize the moisturizing and antioxidant potential of the moringa-formulation as a new skin drug delivery system. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:48:12Z 2020-12-12T01:48:12Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.sajb.2019.10.011 South African Journal of Botany, v. 129, p. 404-411. 0254-6299 http://hdl.handle.net/11449/199745 10.1016/j.sajb.2019.10.011 2-s2.0-85075871834 |
url |
http://dx.doi.org/10.1016/j.sajb.2019.10.011 http://hdl.handle.net/11449/199745 |
identifier_str_mv |
South African Journal of Botany, v. 129, p. 404-411. 0254-6299 10.1016/j.sajb.2019.10.011 2-s2.0-85075871834 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
South African Journal of Botany |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
404-411 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128317197385728 |