Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques

Detalhes bibliográficos
Autor(a) principal: Álvarez-Román, R.
Data de Publicação: 2020
Outros Autores: Silva-Flores, P. G., Galindo-Rodríguez, S. A., Huerta-Heredia, A. A., Vilegas, W. [UNESP], Paniagua-Vega, D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.sajb.2019.10.011
http://hdl.handle.net/11449/199745
Resumo: The phytochemical profile, formulations (nanoparticles and gel), moisturizing and antioxidant potential of a hydroalcoholic fraction of Moringa oleifera leaves (HFM) were determined. These were obtained through the application of eco-friendly strategies of cultivation and processing. The HFM phytochemical analysis by ESI-IT-MSn showed the presence of seven compounds (flavonoids and phenolic acids). The viscosity, pH and particle size of HFM formulations ensure the suitability for topical application. Antioxidant activity was determined by inhibition of lipid peroxidation and ferric thiocyanate in vitro; it was confirmed that HFM and in formulations showed a significant inhibition of oxidation. In relation to the in vitro skin biophysical evaluation for topical formulations of HFM, water content, lipids and trans-epidermal water loss on the skin were favored with the presence of HFM. In addition, skin pH was not been modified. Our results emphasize the moisturizing and antioxidant potential of the moringa-formulation as a new skin drug delivery system.
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spelling Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniquesESI-IT-MSnGelHydroalcoholic extractMoringa oleíferaNanoparticlesProtected croppingSkin bioengineering techniquesSPEThe phytochemical profile, formulations (nanoparticles and gel), moisturizing and antioxidant potential of a hydroalcoholic fraction of Moringa oleifera leaves (HFM) were determined. These were obtained through the application of eco-friendly strategies of cultivation and processing. The HFM phytochemical analysis by ESI-IT-MSn showed the presence of seven compounds (flavonoids and phenolic acids). The viscosity, pH and particle size of HFM formulations ensure the suitability for topical application. Antioxidant activity was determined by inhibition of lipid peroxidation and ferric thiocyanate in vitro; it was confirmed that HFM and in formulations showed a significant inhibition of oxidation. In relation to the in vitro skin biophysical evaluation for topical formulations of HFM, water content, lipids and trans-epidermal water loss on the skin were favored with the presence of HFM. In addition, skin pH was not been modified. Our results emphasize the moisturizing and antioxidant potential of the moringa-formulation as a new skin drug delivery system.Consejo Nacional de Ciencia y TecnologíaDepartamento de Química Analítica Facultad de Medicina Universidad Autónoma de Nuevo León, Av. Fco. I. Madero y Dr. E. Aguirre Pequeño s/nDepartamento de Química Analítica Facultad de Ciencias Biológicas Universidad Autónoma de Nuevo León, Av. Pedro de Alba s/nInstituto de Biotecnología. Universidad del Papaloapan, Av. Circuito Central No. 200 Col. Parque Industrial. TuxtepecInstituto de Biociências – Câmpus do litoral Paulista UNESP – Universidade Estadual Paulista, Praça Dom Infante Henrique s/n, Parque Bitaru CEP 11330-900, São VicenteCátedras CONACYT-UANLCátedras CONACYT-UNPAInstituto de Biociências – Câmpus do litoral Paulista UNESP – Universidade Estadual Paulista, Praça Dom Infante Henrique s/n, Parque Bitaru CEP 11330-900, São VicenteConsejo Nacional de Ciencia y Tecnología: -Consejo Nacional de Ciencia y Tecnología: 284813Consejo Nacional de Ciencia y Tecnología: CB/2016Universidad Autónoma de Nuevo LeónInstituto de Biotecnología. Universidad del PapaloapanUniversidade Estadual Paulista (Unesp)Cátedras CONACYT-UANLCátedras CONACYT-UNPAÁlvarez-Román, R.Silva-Flores, P. G.Galindo-Rodríguez, S. A.Huerta-Heredia, A. A.Vilegas, W. [UNESP]Paniagua-Vega, D.2020-12-12T01:48:12Z2020-12-12T01:48:12Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article404-411http://dx.doi.org/10.1016/j.sajb.2019.10.011South African Journal of Botany, v. 129, p. 404-411.0254-6299http://hdl.handle.net/11449/19974510.1016/j.sajb.2019.10.0112-s2.0-85075871834Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSouth African Journal of Botanyinfo:eu-repo/semantics/openAccess2021-10-23T09:26:34Zoai:repositorio.unesp.br:11449/199745Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:06:48.981249Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
title Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
spellingShingle Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
Álvarez-Román, R.
ESI-IT-MSn
Gel
Hydroalcoholic extract
Moringa oleífera
Nanoparticles
Protected cropping
Skin bioengineering techniques
SPE
title_short Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
title_full Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
title_fullStr Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
title_full_unstemmed Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
title_sort Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques
author Álvarez-Román, R.
author_facet Álvarez-Román, R.
Silva-Flores, P. G.
Galindo-Rodríguez, S. A.
Huerta-Heredia, A. A.
Vilegas, W. [UNESP]
Paniagua-Vega, D.
author_role author
author2 Silva-Flores, P. G.
Galindo-Rodríguez, S. A.
Huerta-Heredia, A. A.
Vilegas, W. [UNESP]
Paniagua-Vega, D.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Autónoma de Nuevo León
Instituto de Biotecnología. Universidad del Papaloapan
Universidade Estadual Paulista (Unesp)
Cátedras CONACYT-UANL
Cátedras CONACYT-UNPA
dc.contributor.author.fl_str_mv Álvarez-Román, R.
Silva-Flores, P. G.
Galindo-Rodríguez, S. A.
Huerta-Heredia, A. A.
Vilegas, W. [UNESP]
Paniagua-Vega, D.
dc.subject.por.fl_str_mv ESI-IT-MSn
Gel
Hydroalcoholic extract
Moringa oleífera
Nanoparticles
Protected cropping
Skin bioengineering techniques
SPE
topic ESI-IT-MSn
Gel
Hydroalcoholic extract
Moringa oleífera
Nanoparticles
Protected cropping
Skin bioengineering techniques
SPE
description The phytochemical profile, formulations (nanoparticles and gel), moisturizing and antioxidant potential of a hydroalcoholic fraction of Moringa oleifera leaves (HFM) were determined. These were obtained through the application of eco-friendly strategies of cultivation and processing. The HFM phytochemical analysis by ESI-IT-MSn showed the presence of seven compounds (flavonoids and phenolic acids). The viscosity, pH and particle size of HFM formulations ensure the suitability for topical application. Antioxidant activity was determined by inhibition of lipid peroxidation and ferric thiocyanate in vitro; it was confirmed that HFM and in formulations showed a significant inhibition of oxidation. In relation to the in vitro skin biophysical evaluation for topical formulations of HFM, water content, lipids and trans-epidermal water loss on the skin were favored with the presence of HFM. In addition, skin pH was not been modified. Our results emphasize the moisturizing and antioxidant potential of the moringa-formulation as a new skin drug delivery system.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T01:48:12Z
2020-12-12T01:48:12Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.sajb.2019.10.011
South African Journal of Botany, v. 129, p. 404-411.
0254-6299
http://hdl.handle.net/11449/199745
10.1016/j.sajb.2019.10.011
2-s2.0-85075871834
url http://dx.doi.org/10.1016/j.sajb.2019.10.011
http://hdl.handle.net/11449/199745
identifier_str_mv South African Journal of Botany, v. 129, p. 404-411.
0254-6299
10.1016/j.sajb.2019.10.011
2-s2.0-85075871834
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv South African Journal of Botany
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 404-411
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128317197385728

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