Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1017/S1041610215002069 http://hdl.handle.net/11449/172328 |
Resumo: | Background: Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular consideration on severity levels of dementia. Methods: AD patients (n = 156) aged 76.7 years from Brazilian clinical centers were assessed to diagnose the five neuropsychiatric syndromes measured by the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): psychosis, agitation, affective, apathy, and sleep. These syndromes were then analyzed for their correlation with the Global Deterioration Scale (GDS). To analyze the association of neuropsychiatric syndromes with the GDS, considering the total sample and patients grouped by dementia severity levels, we applied the coefficient of multiple correlation (Ryy), adjusted multiple linear regression, and the coefficient of determination (R2yx). We tested the significance of correlation coefficients using the Student t-test for simple correlations (a single independent variable) and analysis of variance (ANOVA) for multiple correlations. ANOVA was also used to compare means of demographic and some clinical variables at different levels of dementia. Results: For the total sample, apathy and agitation syndromes were most strongly correlated (0.74; 0.72, respectively) with clinical deterioration according to the GDS, followed by psychosis (0.59), affective (0.45), and sleep syndromes (0.34). Agitation significantly correlated with mild and moderate dementia (CDR 1: 0.45; and CDR 2: 0.69, respectively). At CDR 2, agitation and affective syndromes were most strongly correlated (0.69; 0.59, respectively) with clinical deterioration while at CDR 3, the apathy syndrome was most strongly correlated with clinical deterioration (0.52). Conclusions: Agitation, apathy, and affective disorders were the syndromes most strongly correlated with global deterioration in AD patients, becoming more evident at severe stages of dementia. |
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Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patientsAlzheimer's diseasedementiaglobal deteriorationneuropsychiatric syndromesBackground: Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular consideration on severity levels of dementia. Methods: AD patients (n = 156) aged 76.7 years from Brazilian clinical centers were assessed to diagnose the five neuropsychiatric syndromes measured by the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): psychosis, agitation, affective, apathy, and sleep. These syndromes were then analyzed for their correlation with the Global Deterioration Scale (GDS). To analyze the association of neuropsychiatric syndromes with the GDS, considering the total sample and patients grouped by dementia severity levels, we applied the coefficient of multiple correlation (Ryy), adjusted multiple linear regression, and the coefficient of determination (R2yx). We tested the significance of correlation coefficients using the Student t-test for simple correlations (a single independent variable) and analysis of variance (ANOVA) for multiple correlations. ANOVA was also used to compare means of demographic and some clinical variables at different levels of dementia. Results: For the total sample, apathy and agitation syndromes were most strongly correlated (0.74; 0.72, respectively) with clinical deterioration according to the GDS, followed by psychosis (0.59), affective (0.45), and sleep syndromes (0.34). Agitation significantly correlated with mild and moderate dementia (CDR 1: 0.45; and CDR 2: 0.69, respectively). At CDR 2, agitation and affective syndromes were most strongly correlated (0.69; 0.59, respectively) with clinical deterioration while at CDR 3, the apathy syndrome was most strongly correlated with clinical deterioration (0.52). Conclusions: Agitation, apathy, and affective disorders were the syndromes most strongly correlated with global deterioration in AD patients, becoming more evident at severe stages of dementia.Biosciences Institute Campus of Rio Claro-SP UNESP - Universidade Estadual PaulistaDepartment and Institute of Psychiatry Faculty of Medicine University of Sao PauloCenter for Alzheimer's Disease and Related Disorders Institute of Psychiatry Federal University of Rio de Janeiro-RJDepartment of Statistics Applied Mathematics and Computer Sciences UNESP - Universidade Estadual Paulista Center of Environmental Studies (CEA)Department of Sociology and Gerontology Miami UniversityBiosciences Institute Campus of Rio Claro-SP UNESP - Universidade Estadual PaulistaDepartment of Statistics Applied Mathematics and Computer Sciences UNESP - Universidade Estadual Paulista Center of Environmental Studies (CEA)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Federal University of Rio de Janeiro-RJMiami UniversityStella, Florindo [UNESP]Laks, JersonGovone, José Sílvio [UNESP]De Medeiros, KateForlenza, Orestes Vicente2018-12-11T16:59:44Z2018-12-11T16:59:44Z2016-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article779-786application/pdfhttp://dx.doi.org/10.1017/S1041610215002069International Psychogeriatrics, v. 28, n. 5, p. 779-786, 2016.1741-203X1041-6102http://hdl.handle.net/11449/17232810.1017/S10416102150020692-s2.0-849502988392-s2.0-84950298839.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Psychogeriatrics1,048info:eu-repo/semantics/openAccess2024-04-10T19:22:25Zoai:repositorio.unesp.br:11449/172328Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:46:22.649187Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
title |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
spellingShingle |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients Stella, Florindo [UNESP] Alzheimer's disease dementia global deterioration neuropsychiatric syndromes |
title_short |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
title_full |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
title_fullStr |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
title_full_unstemmed |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
title_sort |
Association of neuropsychiatric syndromes with global clinical deterioration in Alzheimer's disease patients |
author |
Stella, Florindo [UNESP] |
author_facet |
Stella, Florindo [UNESP] Laks, Jerson Govone, José Sílvio [UNESP] De Medeiros, Kate Forlenza, Orestes Vicente |
author_role |
author |
author2 |
Laks, Jerson Govone, José Sílvio [UNESP] De Medeiros, Kate Forlenza, Orestes Vicente |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Federal University of Rio de Janeiro-RJ Miami University |
dc.contributor.author.fl_str_mv |
Stella, Florindo [UNESP] Laks, Jerson Govone, José Sílvio [UNESP] De Medeiros, Kate Forlenza, Orestes Vicente |
dc.subject.por.fl_str_mv |
Alzheimer's disease dementia global deterioration neuropsychiatric syndromes |
topic |
Alzheimer's disease dementia global deterioration neuropsychiatric syndromes |
description |
Background: Data on the relationship between behavioral disturbances in Alzheimer's disease (AD) and global clinical deterioration is still controversial. The purpose of this study was to explore potential correlations of neuropsychiatric syndromes with global clinical deterioration in patients with AD, with particular consideration on severity levels of dementia. Methods: AD patients (n = 156) aged 76.7 years from Brazilian clinical centers were assessed to diagnose the five neuropsychiatric syndromes measured by the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): psychosis, agitation, affective, apathy, and sleep. These syndromes were then analyzed for their correlation with the Global Deterioration Scale (GDS). To analyze the association of neuropsychiatric syndromes with the GDS, considering the total sample and patients grouped by dementia severity levels, we applied the coefficient of multiple correlation (Ryy), adjusted multiple linear regression, and the coefficient of determination (R2yx). We tested the significance of correlation coefficients using the Student t-test for simple correlations (a single independent variable) and analysis of variance (ANOVA) for multiple correlations. ANOVA was also used to compare means of demographic and some clinical variables at different levels of dementia. Results: For the total sample, apathy and agitation syndromes were most strongly correlated (0.74; 0.72, respectively) with clinical deterioration according to the GDS, followed by psychosis (0.59), affective (0.45), and sleep syndromes (0.34). Agitation significantly correlated with mild and moderate dementia (CDR 1: 0.45; and CDR 2: 0.69, respectively). At CDR 2, agitation and affective syndromes were most strongly correlated (0.69; 0.59, respectively) with clinical deterioration while at CDR 3, the apathy syndrome was most strongly correlated with clinical deterioration (0.52). Conclusions: Agitation, apathy, and affective disorders were the syndromes most strongly correlated with global deterioration in AD patients, becoming more evident at severe stages of dementia. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-05-01 2018-12-11T16:59:44Z 2018-12-11T16:59:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1017/S1041610215002069 International Psychogeriatrics, v. 28, n. 5, p. 779-786, 2016. 1741-203X 1041-6102 http://hdl.handle.net/11449/172328 10.1017/S1041610215002069 2-s2.0-84950298839 2-s2.0-84950298839.pdf |
url |
http://dx.doi.org/10.1017/S1041610215002069 http://hdl.handle.net/11449/172328 |
identifier_str_mv |
International Psychogeriatrics, v. 28, n. 5, p. 779-786, 2016. 1741-203X 1041-6102 10.1017/S1041610215002069 2-s2.0-84950298839 2-s2.0-84950298839.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Psychogeriatrics 1,048 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
779-786 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128978449334272 |