Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ejmech.2022.114640 http://hdl.handle.net/11449/241502 |
Resumo: | Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant results in the fight against some diseases. Antimicrobial peptides (AMPs) are biomacromolecules with potential activity against multi/extensively drug-resistant bacteria, with a lower risk of generating bacterial resistance. They can be considered an excellent biotechnological alternative to conventional drugs. However, the application of several AMPs to biological systems is hampered by their poor stability and lifetime, inactivating them completely. Therefore, nanotechnology plays an important role in the development of new AMP-based drugs, protecting and carrying the bioactive to the target. This is the first review article on the different reported nanosystems using AMPs against bacteria listed on the WHO priority list. The current shortage of information implies a nanobiotechnological potential to obtain new drugs or repurpose drugs based on the AMP-drug synergistic effect. |
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Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteriaAMPCarbapenem-resistantCephalosporin-resistantFluoroquinolone-resistantNanosystemsNanotechnologyNanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant results in the fight against some diseases. Antimicrobial peptides (AMPs) are biomacromolecules with potential activity against multi/extensively drug-resistant bacteria, with a lower risk of generating bacterial resistance. They can be considered an excellent biotechnological alternative to conventional drugs. However, the application of several AMPs to biological systems is hampered by their poor stability and lifetime, inactivating them completely. Therefore, nanotechnology plays an important role in the development of new AMP-based drugs, protecting and carrying the bioactive to the target. This is the first review article on the different reported nanosystems using AMPs against bacteria listed on the WHO priority list. The current shortage of information implies a nanobiotechnological potential to obtain new drugs or repurpose drugs based on the AMP-drug synergistic effect.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory, AraraquaraUniversidad Católica de Santa María Vicerrectorado de Investigación Facultad de Ciencias Farmacéuticas Bioquímicas y BiotecnológicasLaboratory of Nanobiotechnology Department of Genetics and Morphology Institute of Biological Sciences University of BrasiliaSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines, AraraquaraSão Paulo State University (UNESP) School of Sciences and Engineering, TupãSão Paulo State University (UNESP) Institute of Chemistry, AraraquaraSão Paulo State University (UNESP) School of Pharmaceutical Sciences Tuberculosis Research Laboratory, AraraquaraSão Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Drugs and Medicines, AraraquaraSão Paulo State University (UNESP) School of Sciences and Engineering, TupãSão Paulo State University (UNESP) Institute of Chemistry, AraraquaraFAPESP: 2018/25707-3FAPESP: 2020/13497-4FAPESP: 2020/16573-3FAPESP: 2021/14603-5CNPq: 404181/2019-8CNPq: 429139/2018-7Universidade Estadual Paulista (UNESP)Facultad de Ciencias Farmacéuticas Bioquímicas y BiotecnológicasUniversity of BrasiliaRoque-Borda, Cesar Augusto [UNESP]Bento da Silva, PatriciaRodrigues, Mosar CorrêaDi Filippo, Leonardo Delello [UNESP]Duarte, Jonatas L. [UNESP]Chorilli, Marlus [UNESP]Vicente, Eduardo Festozo [UNESP]Garrido, Saulo Santesso [UNESP]Rogério Pavan, Fernando [UNESP]2023-03-01T21:06:44Z2023-03-01T21:06:44Z2022-11-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.ejmech.2022.114640European Journal of Medicinal Chemistry, v. 241.1768-32540223-5234http://hdl.handle.net/11449/24150210.1016/j.ejmech.2022.1146402-s2.0-85135822708Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Medicinal Chemistryinfo:eu-repo/semantics/openAccess2024-06-24T13:44:53Zoai:repositorio.unesp.br:11449/241502Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:57:59.909120Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
title |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
spellingShingle |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria Roque-Borda, Cesar Augusto [UNESP] AMP Carbapenem-resistant Cephalosporin-resistant Fluoroquinolone-resistant Nanosystems Nanotechnology |
title_short |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
title_full |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
title_fullStr |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
title_full_unstemmed |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
title_sort |
Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria |
author |
Roque-Borda, Cesar Augusto [UNESP] |
author_facet |
Roque-Borda, Cesar Augusto [UNESP] Bento da Silva, Patricia Rodrigues, Mosar Corrêa Di Filippo, Leonardo Delello [UNESP] Duarte, Jonatas L. [UNESP] Chorilli, Marlus [UNESP] Vicente, Eduardo Festozo [UNESP] Garrido, Saulo Santesso [UNESP] Rogério Pavan, Fernando [UNESP] |
author_role |
author |
author2 |
Bento da Silva, Patricia Rodrigues, Mosar Corrêa Di Filippo, Leonardo Delello [UNESP] Duarte, Jonatas L. [UNESP] Chorilli, Marlus [UNESP] Vicente, Eduardo Festozo [UNESP] Garrido, Saulo Santesso [UNESP] Rogério Pavan, Fernando [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Facultad de Ciencias Farmacéuticas Bioquímicas y Biotecnológicas University of Brasilia |
dc.contributor.author.fl_str_mv |
Roque-Borda, Cesar Augusto [UNESP] Bento da Silva, Patricia Rodrigues, Mosar Corrêa Di Filippo, Leonardo Delello [UNESP] Duarte, Jonatas L. [UNESP] Chorilli, Marlus [UNESP] Vicente, Eduardo Festozo [UNESP] Garrido, Saulo Santesso [UNESP] Rogério Pavan, Fernando [UNESP] |
dc.subject.por.fl_str_mv |
AMP Carbapenem-resistant Cephalosporin-resistant Fluoroquinolone-resistant Nanosystems Nanotechnology |
topic |
AMP Carbapenem-resistant Cephalosporin-resistant Fluoroquinolone-resistant Nanosystems Nanotechnology |
description |
Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant results in the fight against some diseases. Antimicrobial peptides (AMPs) are biomacromolecules with potential activity against multi/extensively drug-resistant bacteria, with a lower risk of generating bacterial resistance. They can be considered an excellent biotechnological alternative to conventional drugs. However, the application of several AMPs to biological systems is hampered by their poor stability and lifetime, inactivating them completely. Therefore, nanotechnology plays an important role in the development of new AMP-based drugs, protecting and carrying the bioactive to the target. This is the first review article on the different reported nanosystems using AMPs against bacteria listed on the WHO priority list. The current shortage of information implies a nanobiotechnological potential to obtain new drugs or repurpose drugs based on the AMP-drug synergistic effect. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-05 2023-03-01T21:06:44Z 2023-03-01T21:06:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ejmech.2022.114640 European Journal of Medicinal Chemistry, v. 241. 1768-3254 0223-5234 http://hdl.handle.net/11449/241502 10.1016/j.ejmech.2022.114640 2-s2.0-85135822708 |
url |
http://dx.doi.org/10.1016/j.ejmech.2022.114640 http://hdl.handle.net/11449/241502 |
identifier_str_mv |
European Journal of Medicinal Chemistry, v. 241. 1768-3254 0223-5234 10.1016/j.ejmech.2022.114640 2-s2.0-85135822708 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Medicinal Chemistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128296541487104 |