Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.colsurfb.2019.06.039 http://hdl.handle.net/11449/184643 |
Resumo: | Flavonoid-metal complexes are widely studied because of their interesting luminescent behavior and biological activity. Despite the extensive exploration of flavonoid-metal coordination processes in solution, the formation of complexes using the flavonoid molecule inserted in a lipid membrane has been little investigated. This effect could provide important insight into the biological activity of flavonoids at lipid membranes and could represent an attractive strategy to design supramolecular structures. Here, we studied the complexation between Sr2+ and morin inserted in an octadecylphosphonic acid (OPA) Langmuir monolayer. This is a relevant system due to the synergism imposed by the association of the Sr2+ ability to control bone formation/resorption with the morin antioxidative effect. Morin incorporation into the OPA monolayers and further Sr2+ complexation were monitored by surface pressure isotherms. Electronic absorption spectroscopy and fluorescence techniques showed Srmorin complexation both in solution and at the air-liquid interface. Although morin complexation has been described to occur only at basic pH, the specific thermodynamic properties at the air-liquid interface drove metal complexation. LB films were deposited on Ti surfaces, and the resulting OPA/Sr-morin coatings exhibited high surface free energy and increase on its polar component. This optimized surface feature supported further serum protein adsorption and osteoblast growth and differentiation, indicating that these lipid-based coatings are promising for bioactive coating design. This study paves the way for the use of this lipid-based coating in the design of implants for faster osteointegration. Moreover, flavonoid-metal complexation at membranes could also help to shed light on the biological role played by flavonoids. |
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Repositório Institucional da UNESP |
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2946 |
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Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating designFlavonoid-metal complexesLangmuir monolayersFluorescenceSurface modificationTitaniumOsteoblastsFlavonoid-metal complexes are widely studied because of their interesting luminescent behavior and biological activity. Despite the extensive exploration of flavonoid-metal coordination processes in solution, the formation of complexes using the flavonoid molecule inserted in a lipid membrane has been little investigated. This effect could provide important insight into the biological activity of flavonoids at lipid membranes and could represent an attractive strategy to design supramolecular structures. Here, we studied the complexation between Sr2+ and morin inserted in an octadecylphosphonic acid (OPA) Langmuir monolayer. This is a relevant system due to the synergism imposed by the association of the Sr2+ ability to control bone formation/resorption with the morin antioxidative effect. Morin incorporation into the OPA monolayers and further Sr2+ complexation were monitored by surface pressure isotherms. Electronic absorption spectroscopy and fluorescence techniques showed Srmorin complexation both in solution and at the air-liquid interface. Although morin complexation has been described to occur only at basic pH, the specific thermodynamic properties at the air-liquid interface drove metal complexation. LB films were deposited on Ti surfaces, and the resulting OPA/Sr-morin coatings exhibited high surface free energy and increase on its polar component. This optimized surface feature supported further serum protein adsorption and osteoblast growth and differentiation, indicating that these lipid-based coatings are promising for bioactive coating design. This study paves the way for the use of this lipid-based coating in the design of implants for faster osteointegration. Moreover, flavonoid-metal complexation at membranes could also help to shed light on the biological role played by flavonoids.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo, BrazilUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, BrazilUniv Sao Paulo, Dept Fis, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo, BrazilUniv Estadual Paulista, Dept Fis, Fac Ciencias & Tecnol, Sao Paulo, BrazilUniv Estadual Paulista, Dept Fis, Fac Ciencias & Tecnol, Sao Paulo, BrazilFAPESP: 2015/08774-0FAPESP: 2017/08892-9FAPESP: 2016/21236-0Elsevier B.V.Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Cruz, M. A. E.Soares, M. P. R.Pazin, W. [UNESP]Ito, A. S.Fukada, S. Y.Ciancaglini, P.Ramos, A. P.2019-10-04T12:15:33Z2019-10-04T12:15:33Z2019-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article856-863http://dx.doi.org/10.1016/j.colsurfb.2019.06.039Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier, v. 181, p. 856-863, 2019.0927-7765http://hdl.handle.net/11449/18464310.1016/j.colsurfb.2019.06.039WOS:000481565300099Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengColloids And Surfaces B-biointerfacesinfo:eu-repo/semantics/openAccess2021-10-23T02:05:51Zoai:repositorio.unesp.br:11449/184643Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:16:24.368456Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
title |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
spellingShingle |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design Cruz, M. A. E. Flavonoid-metal complexes Langmuir monolayers Fluorescence Surface modification Titanium Osteoblasts |
title_short |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
title_full |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
title_fullStr |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
title_full_unstemmed |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
title_sort |
Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design |
author |
Cruz, M. A. E. |
author_facet |
Cruz, M. A. E. Soares, M. P. R. Pazin, W. [UNESP] Ito, A. S. Fukada, S. Y. Ciancaglini, P. Ramos, A. P. |
author_role |
author |
author2 |
Soares, M. P. R. Pazin, W. [UNESP] Ito, A. S. Fukada, S. Y. Ciancaglini, P. Ramos, A. P. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Cruz, M. A. E. Soares, M. P. R. Pazin, W. [UNESP] Ito, A. S. Fukada, S. Y. Ciancaglini, P. Ramos, A. P. |
dc.subject.por.fl_str_mv |
Flavonoid-metal complexes Langmuir monolayers Fluorescence Surface modification Titanium Osteoblasts |
topic |
Flavonoid-metal complexes Langmuir monolayers Fluorescence Surface modification Titanium Osteoblasts |
description |
Flavonoid-metal complexes are widely studied because of their interesting luminescent behavior and biological activity. Despite the extensive exploration of flavonoid-metal coordination processes in solution, the formation of complexes using the flavonoid molecule inserted in a lipid membrane has been little investigated. This effect could provide important insight into the biological activity of flavonoids at lipid membranes and could represent an attractive strategy to design supramolecular structures. Here, we studied the complexation between Sr2+ and morin inserted in an octadecylphosphonic acid (OPA) Langmuir monolayer. This is a relevant system due to the synergism imposed by the association of the Sr2+ ability to control bone formation/resorption with the morin antioxidative effect. Morin incorporation into the OPA monolayers and further Sr2+ complexation were monitored by surface pressure isotherms. Electronic absorption spectroscopy and fluorescence techniques showed Srmorin complexation both in solution and at the air-liquid interface. Although morin complexation has been described to occur only at basic pH, the specific thermodynamic properties at the air-liquid interface drove metal complexation. LB films were deposited on Ti surfaces, and the resulting OPA/Sr-morin coatings exhibited high surface free energy and increase on its polar component. This optimized surface feature supported further serum protein adsorption and osteoblast growth and differentiation, indicating that these lipid-based coatings are promising for bioactive coating design. This study paves the way for the use of this lipid-based coating in the design of implants for faster osteointegration. Moreover, flavonoid-metal complexation at membranes could also help to shed light on the biological role played by flavonoids. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:15:33Z 2019-10-04T12:15:33Z 2019-09-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.colsurfb.2019.06.039 Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier, v. 181, p. 856-863, 2019. 0927-7765 http://hdl.handle.net/11449/184643 10.1016/j.colsurfb.2019.06.039 WOS:000481565300099 |
url |
http://dx.doi.org/10.1016/j.colsurfb.2019.06.039 http://hdl.handle.net/11449/184643 |
identifier_str_mv |
Colloids And Surfaces B-biointerfaces. Amsterdam: Elsevier, v. 181, p. 856-863, 2019. 0927-7765 10.1016/j.colsurfb.2019.06.039 WOS:000481565300099 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Colloids And Surfaces B-biointerfaces |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
856-863 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128491762221056 |