Estudo in vivo do potencial anti-inflamatório de uma formulação de curcumina em gel em dentes de rato submetidos à clareação dentária

• Autor(a) principal: Bosisio, Ana Caroline [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149537; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-27/000866231.pdf
• topic: Clareamento dental; Curcumina; Pulpite; Teeth bleaching

Curcumin is a substance which has antioxidant, anti-inflammatory and immunomodulatory properties. Although widely studied by medicine, has not been explored by the dentin pulp complex. It is known that the hydrogen peroxide (H2O2) of bleaching gel can cause biological effects to pulp tissue, that vary from inflammation to necrosis. The objective of this study is to assess the anti-inflammatory potential of curcumin gel in teeth submitted to dental bleaching. 20 rats were divided into 4 groups of 10 each hemi-jaws were used. Was held the aplication of agent bleaching in molars of the right hemi-maxilla, for 30 minutes of application. The molars of the left hemi-maxilla received the bleaching agent vehicle and served as control. Half of the animals received application of curcumin gelfor 10 minutes in each molars. Other half received vehicle Curcumina gel, composed the following groups: G1A- bleaching agent followed by curcumin gel; G1B- vehicle bleaching agent followed by the curcumin gel; G2A- bleaching agent followed by vehicle curcumin gel; G2B - bleaching agent vehicle following the vehicle Curcumina gel. After 2 days, the animals were euthanized and the jaws removed and processed for evaluation in optical microscopy. Tissue sections stained with HE and evaluated by pre-established criteria by assigning scores to microscopic events. The results were analyzed statistically by the Kruskal Wallis and Dunn tests (p <0.05). Observed presence of severe inflammatory infiltrate to necrosis in groups where the bleaching agent was used regardless of the application of curcumin or its vehicle gel. It can be concluded that the gel curcumin applied topically for 10 minutes to the tooth surface after bleaching procedure with H2O2 35% was not able to minimize the effects of the bleaching agent in the pulp tissue