Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C

Detalhes bibliográficos
Autor(a) principal: Pazin, Wallance M. [UNESP]
Data de Publicação: 2020
Outros Autores: Furini, Leonardo N. [UNESP], Solovyeva, Vita, Lemma, Tibebe [UNESP], Rubira, Rafael J. G. [UNESP], Jorgensen, Bjarke, Constantino, Carlos J. L. [UNESP], Brewer, Jonathan R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1177/0003702820904456
http://hdl.handle.net/11449/196894
Resumo: In the following work, the vibrational spectroscopic characteristics of artepillin C are reported by means of Fourier transform infrared (FT-IR) and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and coherent anti-Stokes Raman scattering (CARS) microscopy. Artepillin C is an interesting compound due to its pharmacological properties, including antitumor activity. It is found as the major component of Brazilian green propolis, a resinous mixture produced by bees to protect their hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm(-1), assigned to C=C stretching vibrations from the aromatic ring of artepillin C. From these data, direct visualization of artepillin C could be assessed by means of CARS microscopy, showing differences in the film hydration obtained for its neutral and deprotonated states. Raman-based methods show potential to visualize the uptake and action of artepillin C in biological systems, triggering its interaction with biological systems that are needed to understand its mechanism of action.
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spelling Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin CArtepillin CpropolisRaman spectroscopyCARS microscopysurface-enhanced Raman scatteringSERSimaging techniquesIn the following work, the vibrational spectroscopic characteristics of artepillin C are reported by means of Fourier transform infrared (FT-IR) and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and coherent anti-Stokes Raman scattering (CARS) microscopy. Artepillin C is an interesting compound due to its pharmacological properties, including antitumor activity. It is found as the major component of Brazilian green propolis, a resinous mixture produced by bees to protect their hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm(-1), assigned to C=C stretching vibrations from the aromatic ring of artepillin C. From these data, direct visualization of artepillin C could be assessed by means of CARS microscopy, showing differences in the film hydration obtained for its neutral and deprotonated states. Raman-based methods show potential to visualize the uptake and action of artepillin C in biological systems, triggering its interaction with biological systems that are needed to understand its mechanism of action.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Southern Denmark, Dept Biochem & Mol Biol BMB, Odense, DenmarkSao Paulo State Univ, Sch Technol & Appl Sci, Dept Phys, Presidente Prudente, BrazilUniv Fed Ceara, Dept Phys, Fortaleza, Ceara, BrazilCarl von Ossietzky Univ Oldenburg, Fac Math & Sci, Oldenburg, GermanyNewtec Engn AS, Odense, DenmarkSao Paulo State Univ, Sch Technol & Appl Sci, Dept Phys, Presidente Prudente, BrazilFAPESP: 2016/09633-4FAPESP: 2017/23426-4Sage Publications IncUniv Southern DenmarkUniversidade Estadual Paulista (Unesp)Univ Fed CearaCarl von Ossietzky Univ OldenburgNewtec Engn ASPazin, Wallance M. [UNESP]Furini, Leonardo N. [UNESP]Solovyeva, VitaLemma, Tibebe [UNESP]Rubira, Rafael J. G. [UNESP]Jorgensen, BjarkeConstantino, Carlos J. L. [UNESP]Brewer, Jonathan R.2020-12-10T19:59:34Z2020-12-10T19:59:34Z2020-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article751-757http://dx.doi.org/10.1177/0003702820904456Applied Spectroscopy. Thousand Oaks: Sage Publications Inc, v. 74, n. 7, p. 751-757, 2020.0003-7028http://hdl.handle.net/11449/19689410.1177/0003702820904456WOS:000534500000001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengApplied Spectroscopyinfo:eu-repo/semantics/openAccess2024-06-18T18:18:24Zoai:repositorio.unesp.br:11449/196894Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:10:16.512891Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
title Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
spellingShingle Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
Pazin, Wallance M. [UNESP]
Artepillin C
propolis
Raman spectroscopy
CARS microscopy
surface-enhanced Raman scattering
SERS
imaging techniques
title_short Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
title_full Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
title_fullStr Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
title_full_unstemmed Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
title_sort Vibrational Spectroscopic Characterization and Coherent Anti-Stokes Raman Spectroscopy (CARS) Imaging of Artepillin C
author Pazin, Wallance M. [UNESP]
author_facet Pazin, Wallance M. [UNESP]
Furini, Leonardo N. [UNESP]
Solovyeva, Vita
Lemma, Tibebe [UNESP]
Rubira, Rafael J. G. [UNESP]
Jorgensen, Bjarke
Constantino, Carlos J. L. [UNESP]
Brewer, Jonathan R.
author_role author
author2 Furini, Leonardo N. [UNESP]
Solovyeva, Vita
Lemma, Tibebe [UNESP]
Rubira, Rafael J. G. [UNESP]
Jorgensen, Bjarke
Constantino, Carlos J. L. [UNESP]
Brewer, Jonathan R.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Southern Denmark
Universidade Estadual Paulista (Unesp)
Univ Fed Ceara
Carl von Ossietzky Univ Oldenburg
Newtec Engn AS
dc.contributor.author.fl_str_mv Pazin, Wallance M. [UNESP]
Furini, Leonardo N. [UNESP]
Solovyeva, Vita
Lemma, Tibebe [UNESP]
Rubira, Rafael J. G. [UNESP]
Jorgensen, Bjarke
Constantino, Carlos J. L. [UNESP]
Brewer, Jonathan R.
dc.subject.por.fl_str_mv Artepillin C
propolis
Raman spectroscopy
CARS microscopy
surface-enhanced Raman scattering
SERS
imaging techniques
topic Artepillin C
propolis
Raman spectroscopy
CARS microscopy
surface-enhanced Raman scattering
SERS
imaging techniques
description In the following work, the vibrational spectroscopic characteristics of artepillin C are reported by means of Fourier transform infrared (FT-IR) and Raman spectroscopies, surface-enhanced Raman scattering (SERS), and coherent anti-Stokes Raman scattering (CARS) microscopy. Artepillin C is an interesting compound due to its pharmacological properties, including antitumor activity. It is found as the major component of Brazilian green propolis, a resinous mixture produced by bees to protect their hives against intruders. Vibrational spectroscopic techniques have shown a strong peak at 1599 cm(-1), assigned to C=C stretching vibrations from the aromatic ring of artepillin C. From these data, direct visualization of artepillin C could be assessed by means of CARS microscopy, showing differences in the film hydration obtained for its neutral and deprotonated states. Raman-based methods show potential to visualize the uptake and action of artepillin C in biological systems, triggering its interaction with biological systems that are needed to understand its mechanism of action.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-10T19:59:34Z
2020-12-10T19:59:34Z
2020-04-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1177/0003702820904456
Applied Spectroscopy. Thousand Oaks: Sage Publications Inc, v. 74, n. 7, p. 751-757, 2020.
0003-7028
http://hdl.handle.net/11449/196894
10.1177/0003702820904456
WOS:000534500000001
url http://dx.doi.org/10.1177/0003702820904456
http://hdl.handle.net/11449/196894
identifier_str_mv Applied Spectroscopy. Thousand Oaks: Sage Publications Inc, v. 74, n. 7, p. 751-757, 2020.
0003-7028
10.1177/0003702820904456
WOS:000534500000001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Applied Spectroscopy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 751-757
dc.publisher.none.fl_str_mv Sage Publications Inc
publisher.none.fl_str_mv Sage Publications Inc
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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