Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758)
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992007000400014 http://hdl.handle.net/11449/70083 |
Resumo: | Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15 th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing. |
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Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758)CorneaCorneal ulcerFibrin glueKeratoplastySnake venomAnimaliaCanis familiarisFibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15 th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing.Veterinary Hospital School of Veterinary Medicine Uberaba University (UNIUBE), Uberaba, Minas Gerais StateDepartment of Veterinary Surgery School of Veterinary Medicine and Animal Husbandry (FMVZ) São Paulo State University (UNESP), Botucatu, São Paulo StateLaboratory of Hemostasis Botucatu Medical School (FMB) UNESP, Botucatu, São Paulo StateCenter for the Study of Venoms and Venomous Animals (CEVAP) UNESP, Botucatu, São Paulo StateDepartment of Dermatology and Radiotherapy (FMB) UNESP, Botucatu, São Paulo StateDepartment of Clinical Analysis Araraquara School of Pharmaceutical Sciences (FCFAr) UNESP, Araraquara, São Paulo State, Avenida Afrânio Azevedo, 2140, Olinda, 38020-450, Uberaba, Minas GeraisDepartment of Veterinary Surgery School of Veterinary Medicine and Animal Husbandry (FMVZ) São Paulo State University (UNESP), Botucatu, São Paulo StateLaboratory of Hemostasis Botucatu Medical School (FMB) UNESP, Botucatu, São Paulo StateCenter for the Study of Venoms and Venomous Animals (CEVAP) UNESP, Botucatu, São Paulo StateDepartment of Dermatology and Radiotherapy (FMB) UNESP, Botucatu, São Paulo StateDepartment of Clinical Analysis Araraquara School of Pharmaceutical Sciences (FCFAr) UNESP, Araraquara, São Paulo StateUberaba University (UNIUBE)Universidade Estadual Paulista (Unesp)Sampaio, Renato LinharesRanzani, José Joaquim Titton [UNESP]Brandão, Claudia Valeria Seullner [UNESP]Thomazini-Santos, I. A. [UNESP]Barraviera, B. [UNESP]Barraviera, S. R. C. S. [UNESP]Mendes Giannini, Maria José Soares [UNESP]2014-05-27T11:22:41Z2014-05-27T11:22:41Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article857-873application/pdfhttp://dx.doi.org/10.1590/S1678-91992007000400014Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 857-873, 2007.1678-9199http://hdl.handle.net/11449/7008310.1590/S1678-91992007000400014S1678-91992007000400014WOS:0002513252000142-s2.0-383491586522-s2.0-38349158652.pdf681441767684028610876153890136550000-0002-8059-08260000-0002-2011-5214Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2024-08-14T18:46:08Zoai:repositorio.unesp.br:11449/70083Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T18:46:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
title |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
spellingShingle |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) Sampaio, Renato Linhares Cornea Corneal ulcer Fibrin glue Keratoplasty Snake venom Animalia Canis familiaris |
title_short |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
title_full |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
title_fullStr |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
title_full_unstemmed |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
title_sort |
Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers - Experimental study in dogs (Canis familiaris, Linnaeus, 1758) |
author |
Sampaio, Renato Linhares |
author_facet |
Sampaio, Renato Linhares Ranzani, José Joaquim Titton [UNESP] Brandão, Claudia Valeria Seullner [UNESP] Thomazini-Santos, I. A. [UNESP] Barraviera, B. [UNESP] Barraviera, S. R. C. S. [UNESP] Mendes Giannini, Maria José Soares [UNESP] |
author_role |
author |
author2 |
Ranzani, José Joaquim Titton [UNESP] Brandão, Claudia Valeria Seullner [UNESP] Thomazini-Santos, I. A. [UNESP] Barraviera, B. [UNESP] Barraviera, S. R. C. S. [UNESP] Mendes Giannini, Maria José Soares [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Uberaba University (UNIUBE) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Sampaio, Renato Linhares Ranzani, José Joaquim Titton [UNESP] Brandão, Claudia Valeria Seullner [UNESP] Thomazini-Santos, I. A. [UNESP] Barraviera, B. [UNESP] Barraviera, S. R. C. S. [UNESP] Mendes Giannini, Maria José Soares [UNESP] |
dc.subject.por.fl_str_mv |
Cornea Corneal ulcer Fibrin glue Keratoplasty Snake venom Animalia Canis familiaris |
topic |
Cornea Corneal ulcer Fibrin glue Keratoplasty Snake venom Animalia Canis familiaris |
description |
Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15 th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:41Z 2014-05-27T11:22:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992007000400014 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 857-873, 2007. 1678-9199 http://hdl.handle.net/11449/70083 10.1590/S1678-91992007000400014 S1678-91992007000400014 WOS:000251325200014 2-s2.0-38349158652 2-s2.0-38349158652.pdf 6814417676840286 1087615389013655 0000-0002-8059-0826 0000-0002-2011-5214 |
url |
http://dx.doi.org/10.1590/S1678-91992007000400014 http://hdl.handle.net/11449/70083 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 857-873, 2007. 1678-9199 10.1590/S1678-91992007000400014 S1678-91992007000400014 WOS:000251325200014 2-s2.0-38349158652 2-s2.0-38349158652.pdf 6814417676840286 1087615389013655 0000-0002-8059-0826 0000-0002-2011-5214 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases 1.782 0,573 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
857-873 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128180019527680 |