Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRPE |
Texto Completo: | http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/8611 |
Resumo: | In Brazil and in the world, cancer is a condition that becomes relevant for its epidemiological profile. In this sense, the theme becomes attractive to new studies, gaining momentum in the scientific community with an emphasis on ovarian cancer as one of the malignancies with a poor prognosis. The pineal gland is a tiny endocrine gland that produces melatonin. It is believed that this derivative of serotonin exerts a suppressive effect on gonadotropin secretion and therefore inhibits the growth and function of the gonads. Several studies have evaluated the action of the pineal pinealectomy in experimental animals submitted under different anesthetic protocols, surgical instruments and suture materials. The N -nitroso - N - Methylurea (NMU) has direct carcinogenic action, inducing tumors in various organs in various species. Objective was to establish an experimental model for induction of tumors in the ovaries of 36 Wistar rats into 6 groups, subdivided according to age. Pinealectomizadas not pinealectomizadas and NMU members or as single agents. It is concluded that the improvements in the surgical technique of pinealectomy are applicable in Wistar rats, however, the experimental model of ovarian carcinogenesis in Wistar rats, using with or without pinealectomy intraperitoneal NMU showed practical impossibility in this study due to the absence of tumors. There is the prospect that this work will serve as input for the improvement and optimization of the experimental model of ovarian tumor -inducing agents and, from these, possible treatments. |
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ALMEIDA, Edvaldo Lopes deGUILHERME, Betânia CristinaXAVIER, Gileno Antônio AraújoDUARTE, Helena SimõesSANTOS, Rosilda Maria Barretohttp://lattes.cnpq.br/3776642205741967BURGOS, Fábia Regina Nascimento Fernando2022-07-21T11:57:53Z2014-02-18BURGOS, Fábia Regina Nascimento Fernando. Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados. 2014. 81 f. Tese (Programa de Pós-Graduação em Ciência Veterinária) - Universidade Federal Rural de Pernambuco, Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/8611In Brazil and in the world, cancer is a condition that becomes relevant for its epidemiological profile. In this sense, the theme becomes attractive to new studies, gaining momentum in the scientific community with an emphasis on ovarian cancer as one of the malignancies with a poor prognosis. The pineal gland is a tiny endocrine gland that produces melatonin. It is believed that this derivative of serotonin exerts a suppressive effect on gonadotropin secretion and therefore inhibits the growth and function of the gonads. Several studies have evaluated the action of the pineal pinealectomy in experimental animals submitted under different anesthetic protocols, surgical instruments and suture materials. The N -nitroso - N - Methylurea (NMU) has direct carcinogenic action, inducing tumors in various organs in various species. Objective was to establish an experimental model for induction of tumors in the ovaries of 36 Wistar rats into 6 groups, subdivided according to age. Pinealectomizadas not pinealectomizadas and NMU members or as single agents. It is concluded that the improvements in the surgical technique of pinealectomy are applicable in Wistar rats, however, the experimental model of ovarian carcinogenesis in Wistar rats, using with or without pinealectomy intraperitoneal NMU showed practical impossibility in this study due to the absence of tumors. There is the prospect that this work will serve as input for the improvement and optimization of the experimental model of ovarian tumor -inducing agents and, from these, possible treatments.No Brasil e no mundo, o câncer é uma patologia que ganha relevância pelo seu perfil epidemiológico. Por esse sentido, o tema se torna atraente para novos estudos, conquistando espaço no meio científico com destaque para o câncer de ovário por ser uma das neoplasias malignas de prognóstico reservado. A pineal é uma minúscula glândula endócrina que produz melatonina. Acredita-se que este derivado da serotonina exerça um efeito supressivo na secreção de gonadotrofinas, e por isso iniba o crescimento e a função das gônadas. Vários estudos têm avaliado a ação da pineal em animais experimentais submetidos pinealectomia sob diferentes protocolos anestésicos, instrumentais cirúrgicos e materiais de sutura. O N-Nitroso-N-Methylurea (NMU) tem ação cancerígena direta, induzindo tumores em várias espécies em diversos órgãos. Objetivou-se estabelecer um modelo experimental para indução de tumores nos ovários de 36 Ratas Wistar, em 6 grupos, subdivididas de acordo com a idade. Pinealectomizadas e não pinealectomizadas, e NMU associados ou como agentes únicos. Conclui-se que os aprimoramentos da técnica cirúrgica de pinealectomia são aplicáveis em Ratas Wistar, no entanto, o modelo experimental de carcinogênese ovariana em Ratas Wistar, utilizando o NMU intraperitoneal associado ou não à pinealectomia mostrou inviabilidade prática neste estudo, devido a ausência de tumores. Tem-se a perspectiva de que este trabalho sirva de subsídio para o aperfeiçoamento e otimização do modelo experimental de agentes indutores tumorais ovarianos e, a partir destes, possíveis tratamentos.Submitted by Mario BC (mario@bc.ufrpe.br) on 2022-07-21T11:57:53Z No. of bitstreams: 1 Fabia Regina Nascimento Fernando Burgos.pdf: 1583004 bytes, checksum: 173f5190b7677786802edfe288cdc662 (MD5)Made available in DSpace on 2022-07-21T11:57:53Z (GMT). No. of bitstreams: 1 Fabia Regina Nascimento Fernando Burgos.pdf: 1583004 bytes, checksum: 173f5190b7677786802edfe288cdc662 (MD5) Previous issue date: 2014-02-18application/pdfporUniversidade Federal Rural de PernambucoPrograma de Pós-Graduação em Ciência VeterináriaUFRPEBrasilDepartamento de Medicina VeterináriaIndução tumoralCâncer de ovárioPinealectomiaProcedimento cirúrgicoCIENCIAS AGRARIAS::MEDICINA VETERINARIAAnálise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associadosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis-3061482854177903105600600600-3020210563763616780453670264235017319info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRPEinstname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPEORIGINALFabia Regina Nascimento Fernando Burgos.pdfFabia Regina Nascimento Fernando Burgos.pdfapplication/pdf1583004http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/8611/2/Fabia+Regina+Nascimento+Fernando+Burgos.pdf173f5190b7677786802edfe288cdc662MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/8611/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede2/86112022-07-21 08:57:53.036oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.tede2.ufrpe.br:8080/tede/PUBhttp://www.tede2.ufrpe.br:8080/oai/requestbdtd@ufrpe.br ||bdtd@ufrpe.bropendoar:2024-05-28T12:37:12.596004Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE)false |
dc.title.por.fl_str_mv |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
title |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
spellingShingle |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados BURGOS, Fábia Regina Nascimento Fernando Indução tumoral Câncer de ovário Pinealectomia Procedimento cirúrgico CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
title_full |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
title_fullStr |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
title_full_unstemmed |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
title_sort |
Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados |
author |
BURGOS, Fábia Regina Nascimento Fernando |
author_facet |
BURGOS, Fábia Regina Nascimento Fernando |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
ALMEIDA, Edvaldo Lopes de |
dc.contributor.referee1.fl_str_mv |
GUILHERME, Betânia Cristina |
dc.contributor.referee2.fl_str_mv |
XAVIER, Gileno Antônio Araújo |
dc.contributor.referee3.fl_str_mv |
DUARTE, Helena Simões |
dc.contributor.referee4.fl_str_mv |
SANTOS, Rosilda Maria Barreto |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3776642205741967 |
dc.contributor.author.fl_str_mv |
BURGOS, Fábia Regina Nascimento Fernando |
contributor_str_mv |
ALMEIDA, Edvaldo Lopes de GUILHERME, Betânia Cristina XAVIER, Gileno Antônio Araújo DUARTE, Helena Simões SANTOS, Rosilda Maria Barreto |
dc.subject.por.fl_str_mv |
Indução tumoral Câncer de ovário Pinealectomia Procedimento cirúrgico |
topic |
Indução tumoral Câncer de ovário Pinealectomia Procedimento cirúrgico CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
In Brazil and in the world, cancer is a condition that becomes relevant for its epidemiological profile. In this sense, the theme becomes attractive to new studies, gaining momentum in the scientific community with an emphasis on ovarian cancer as one of the malignancies with a poor prognosis. The pineal gland is a tiny endocrine gland that produces melatonin. It is believed that this derivative of serotonin exerts a suppressive effect on gonadotropin secretion and therefore inhibits the growth and function of the gonads. Several studies have evaluated the action of the pineal pinealectomy in experimental animals submitted under different anesthetic protocols, surgical instruments and suture materials. The N -nitroso - N - Methylurea (NMU) has direct carcinogenic action, inducing tumors in various organs in various species. Objective was to establish an experimental model for induction of tumors in the ovaries of 36 Wistar rats into 6 groups, subdivided according to age. Pinealectomizadas not pinealectomizadas and NMU members or as single agents. It is concluded that the improvements in the surgical technique of pinealectomy are applicable in Wistar rats, however, the experimental model of ovarian carcinogenesis in Wistar rats, using with or without pinealectomy intraperitoneal NMU showed practical impossibility in this study due to the absence of tumors. There is the prospect that this work will serve as input for the improvement and optimization of the experimental model of ovarian tumor -inducing agents and, from these, possible treatments. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-02-18 |
dc.date.accessioned.fl_str_mv |
2022-07-21T11:57:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BURGOS, Fábia Regina Nascimento Fernando. Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados. 2014. 81 f. Tese (Programa de Pós-Graduação em Ciência Veterinária) - Universidade Federal Rural de Pernambuco, Recife. |
dc.identifier.uri.fl_str_mv |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/8611 |
identifier_str_mv |
BURGOS, Fábia Regina Nascimento Fernando. Análise clínica cirúrgica e histopatológica em ratas Wistar (Rattus novergicus albinus) submetidas à pinealectomia e N-nitroso-N-methylurea isolados e associados. 2014. 81 f. Tese (Programa de Pós-Graduação em Ciência Veterinária) - Universidade Federal Rural de Pernambuco, Recife. |
url |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/8611 |
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por |
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por |
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openAccess |
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Universidade Federal Rural de Pernambuco |
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Universidade Federal Rural de Pernambuco |
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