THE IMPORTANCE OF ABSOLUTE QUANTIFICATION OF REGULATORY T LYMPHOCYTES (TREG) IN THE COURSE OF HIV VIRUS INFECTION.: Quantification of lymphocytes (TReg) in HIV infection

• Autor(a) principal: Holanda Nascimento , Matheus
• Data de Publicação: 2024
• Outros Autores: Miralha Costa, Tiago, Silveira Paixão, Ana Paula, Suellen Lopes Castro Mendes, Nilmara, Cardoso de Brito Junior, Lacy
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: Revista de Atenção à Saúde
• Texto Completo: http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/8817
• topic: Linfócitos T Regulatórios; Vírus da Imunodeficiência Humana; HIV; Terapia Antirretroviral de Alta Atividade; Regulatory T cells (Treg); human immunodeficiency virus; HIV; antiretroviral therapy

INTRODUCTION. Regulatory T lymphocytes (TReg) are cells specialized in suppressing super-reactive immune responses as in HIV infection. OBJECTIVES. To verify the absolute concentration of TReg lymphocytes during the course of HIV infection in patients being diagnosed or already undergoing treatment. MATERIALS AND METHODS. Study carried out with 50 individuals who spontaneously sought a private laboratory in Belém - Pará to perform tests to quantify CD4+ and CD8+ T lymphocytes and viral load (Groups 2 and 3) or only blood count (Group 1 - control), in the period of July from 2018 to August 2019. Group 2 consisted of people who had detectable RT-PCR for HIV1/HIV2 at diagnosis; and Group 3 formed by people who had detectable RT-PCR for HIV1/HIV2 and were already on treatment. RESULTS. In Group 1, the median age was 56.5 years and there was a statistical dependence (p = 0.00451) between the absolute values of CD4+ T Lymphocytes and TReg Lymphocytes. In Group 2, the median age was 39.5 years and there was a statistical difference (p=0.00234) only when the viral load was undetectable and the absolute values of TReg lymphocytes were low. In Group 3, the median age was 40.5 years and there was statistical dependence (p = 0.00188) between the absolute values of CD4+ T Lymphocytes and TReg Lymphocytes. CONCLUSION. Our data reinforce the observation of other authors regarding the increase in absolute values of TReg lymphocytes in patients on specific antiretroviral therapy.