Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572021000100409 |
Resumo: | Abstract Objective To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Methodology Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. Results The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p<0.001), clinical TNM staging (p<0.001) and nodal metastasis (p<0.001). The OSCC patients survived for less than 3 and 5 years were showed significantly higher Ki67 LI as compared to diseases free survived more than 3 and 5 years(p<0.001). The three years survival rate of OSCC patient significantly higher with low Ki67 LI (≤45) 96.2%, followed by moderate Ki67 LI (46 to 60) 60.7% and high Ki67 LI (≥61) 37.7% (p<0.001). The five years survival rate of OSCC patient statistically significantly higher with low Ki67 LI (≤45)93.3%, followed by moderate Ki67 LI (46 to 60) 46.8% and Ki67 LI (≥61) 23.3% (p<0.001). Conclusion The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC. |
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Journal of applied oral science (Online) |
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Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinomaOral Squamous Cell CarcinomaKi67 Labelling IndexProliferationPrognosisSurvivalAbstract Objective To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Methodology Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. Results The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p<0.001), clinical TNM staging (p<0.001) and nodal metastasis (p<0.001). The OSCC patients survived for less than 3 and 5 years were showed significantly higher Ki67 LI as compared to diseases free survived more than 3 and 5 years(p<0.001). The three years survival rate of OSCC patient significantly higher with low Ki67 LI (≤45) 96.2%, followed by moderate Ki67 LI (46 to 60) 60.7% and high Ki67 LI (≥61) 37.7% (p<0.001). The five years survival rate of OSCC patient statistically significantly higher with low Ki67 LI (≤45)93.3%, followed by moderate Ki67 LI (46 to 60) 46.8% and Ki67 LI (≥61) 23.3% (p<0.001). Conclusion The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC.Faculdade De Odontologia De Bauru - USP2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572021000100409Journal of Applied Oral Science v.29 2021reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1678-7757-2020-0751info:eu-repo/semantics/openAccessGADBAIL,Amol RamchandraSARODE,Sachin CCHAUDHARY,Minal SGONDIVKAR,Shailesh MTEKADE,Satyajit AshokYUWANATI,MonalPATIL,Shankargoudaeng2021-02-26T00:00:00Zoai:scielo:S1678-77572021000100409Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2021-02-26T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
title |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
spellingShingle |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma GADBAIL,Amol Ramchandra Oral Squamous Cell Carcinoma Ki67 Labelling Index Proliferation Prognosis Survival |
title_short |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
title_full |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
title_fullStr |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
title_full_unstemmed |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
title_sort |
Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma |
author |
GADBAIL,Amol Ramchandra |
author_facet |
GADBAIL,Amol Ramchandra SARODE,Sachin C CHAUDHARY,Minal S GONDIVKAR,Shailesh M TEKADE,Satyajit Ashok YUWANATI,Monal PATIL,Shankargouda |
author_role |
author |
author2 |
SARODE,Sachin C CHAUDHARY,Minal S GONDIVKAR,Shailesh M TEKADE,Satyajit Ashok YUWANATI,Monal PATIL,Shankargouda |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
GADBAIL,Amol Ramchandra SARODE,Sachin C CHAUDHARY,Minal S GONDIVKAR,Shailesh M TEKADE,Satyajit Ashok YUWANATI,Monal PATIL,Shankargouda |
dc.subject.por.fl_str_mv |
Oral Squamous Cell Carcinoma Ki67 Labelling Index Proliferation Prognosis Survival |
topic |
Oral Squamous Cell Carcinoma Ki67 Labelling Index Proliferation Prognosis Survival |
description |
Abstract Objective To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Methodology Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. Results The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p<0.001), clinical TNM staging (p<0.001) and nodal metastasis (p<0.001). The OSCC patients survived for less than 3 and 5 years were showed significantly higher Ki67 LI as compared to diseases free survived more than 3 and 5 years(p<0.001). The three years survival rate of OSCC patient significantly higher with low Ki67 LI (≤45) 96.2%, followed by moderate Ki67 LI (46 to 60) 60.7% and high Ki67 LI (≥61) 37.7% (p<0.001). The five years survival rate of OSCC patient statistically significantly higher with low Ki67 LI (≤45)93.3%, followed by moderate Ki67 LI (46 to 60) 46.8% and Ki67 LI (≥61) 23.3% (p<0.001). Conclusion The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572021000100409 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572021000100409 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-7757-2020-0751 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.29 2021 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936440930107392 |