Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/214376 |
Resumo: | Inflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have an undeniable significance in fine-tuning the magnitude of mediators that directly affect hyper-inflammatory responses and tissue destruction. Fibroblasts, the dominant cells in the gingival connective tissue, are a very heterogeneous population of cells, and more recently they have been receiving well deserved attention as central players and often the ‘principal dancers’ of many pathological processes ranging from inflammation and fibrosis to altered immunity and cancer. The goal of the current investigation is to dive into the exact role of the stromal fibroblast and the responsible mechanistic factors involved in both regulation and dysregulation of the inflammatory responses. This article reviews the most recent literature on how fibroblasts, in their different activation states or subtypes, play a crucial role in contributing to inflammatory outcomes. We will focus on recent findings on inflammatory diseases. We will also provide connections regarding the stromal-immune relationship, which supports the idea of fibroblast coming out from the ‘ensemble’ of cell types to the protagonist role in immunometabolism and inflammaging. Additionally, we discuss the current advances in variation of fibroblast nomenclature and division into clusters with their own suggested function and particularities in gene expression. Here, we provide a perspective for the periodontal implications, discussing the fibroblast role in the infection-driven and inflammatory mediated diseases such as periodontitis. |
id |
USP-17_68fa43a189bea7ffae75416dea8c5ae8 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/214376 |
network_acronym_str |
USP-17 |
network_name_str |
Journal of applied oral science (Online) |
repository_id_str |
|
spelling |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammagingFibroblastsStromal cellsInflammationAgingMetabolismInflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have an undeniable significance in fine-tuning the magnitude of mediators that directly affect hyper-inflammatory responses and tissue destruction. Fibroblasts, the dominant cells in the gingival connective tissue, are a very heterogeneous population of cells, and more recently they have been receiving well deserved attention as central players and often the ‘principal dancers’ of many pathological processes ranging from inflammation and fibrosis to altered immunity and cancer. The goal of the current investigation is to dive into the exact role of the stromal fibroblast and the responsible mechanistic factors involved in both regulation and dysregulation of the inflammatory responses. This article reviews the most recent literature on how fibroblasts, in their different activation states or subtypes, play a crucial role in contributing to inflammatory outcomes. We will focus on recent findings on inflammatory diseases. We will also provide connections regarding the stromal-immune relationship, which supports the idea of fibroblast coming out from the ‘ensemble’ of cell types to the protagonist role in immunometabolism and inflammaging. Additionally, we discuss the current advances in variation of fibroblast nomenclature and division into clusters with their own suggested function and particularities in gene expression. Here, we provide a perspective for the periodontal implications, discussing the fibroblast role in the infection-driven and inflammatory mediated diseases such as periodontitis.Universidade de São Paulo. Faculdade de Odontologia de Bauru2023-07-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/21437610.1590/1678-7757-2023-0050Journal of Applied Oral Science; Vol. 31 (2023); e20230050Journal of Applied Oral Science; Vol. 31 (2023); e20230050Journal of Applied Oral Science; v. 31 (2023); e202300501678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/214376/196612Copyright (c) 2023 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSerrano-Lopez, RogelioMorandini, Ana Carolina2023-07-17T17:15:54Zoai:revistas.usp.br:article/214376Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2023-07-17T17:15:54Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
title |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
spellingShingle |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging Serrano-Lopez, Rogelio Fibroblasts Stromal cells Inflammation Aging Metabolism |
title_short |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
title_full |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
title_fullStr |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
title_full_unstemmed |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
title_sort |
Fibroblasts at the curtain call: from ensemble to principal dancers in immunometabolism and inflammaging |
author |
Serrano-Lopez, Rogelio |
author_facet |
Serrano-Lopez, Rogelio Morandini, Ana Carolina |
author_role |
author |
author2 |
Morandini, Ana Carolina |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Serrano-Lopez, Rogelio Morandini, Ana Carolina |
dc.subject.por.fl_str_mv |
Fibroblasts Stromal cells Inflammation Aging Metabolism |
topic |
Fibroblasts Stromal cells Inflammation Aging Metabolism |
description |
Inflammation is a necessary step in response to injuries, being vital in restoring homeostasis and facilitating tissue healing. Among the cells that play a crucial role in inflammatory responses, stromal cells, including fibroblasts, have an undeniable significance in fine-tuning the magnitude of mediators that directly affect hyper-inflammatory responses and tissue destruction. Fibroblasts, the dominant cells in the gingival connective tissue, are a very heterogeneous population of cells, and more recently they have been receiving well deserved attention as central players and often the ‘principal dancers’ of many pathological processes ranging from inflammation and fibrosis to altered immunity and cancer. The goal of the current investigation is to dive into the exact role of the stromal fibroblast and the responsible mechanistic factors involved in both regulation and dysregulation of the inflammatory responses. This article reviews the most recent literature on how fibroblasts, in their different activation states or subtypes, play a crucial role in contributing to inflammatory outcomes. We will focus on recent findings on inflammatory diseases. We will also provide connections regarding the stromal-immune relationship, which supports the idea of fibroblast coming out from the ‘ensemble’ of cell types to the protagonist role in immunometabolism and inflammaging. Additionally, we discuss the current advances in variation of fibroblast nomenclature and division into clusters with their own suggested function and particularities in gene expression. Here, we provide a perspective for the periodontal implications, discussing the fibroblast role in the infection-driven and inflammatory mediated diseases such as periodontitis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/214376 10.1590/1678-7757-2023-0050 |
url |
https://www.revistas.usp.br/jaos/article/view/214376 |
identifier_str_mv |
10.1590/1678-7757-2023-0050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/214376/196612 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 31 (2023); e20230050 Journal of Applied Oral Science; Vol. 31 (2023); e20230050 Journal of Applied Oral Science; v. 31 (2023); e20230050 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221683586433024 |