Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis

Bibliographic Details
Main Author: Cardoso,Camila Lopes
Publication Date: 2005
Other Authors: Prado,Renata Falchete do, Taveira,Luís Antônio de Assis
Format: Article
Language: eng
Source: Journal of applied oral science (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000300016
Summary: Studies have related the action of alcohol on the oral mucosa as a promoter of carcinogenesis, once most oral antiseptics contain alcohol. Its utilization for mouthrinses from 30 to 60 seconds, as indicated on the labels, yields a longer-lasting topical action when compared to the intake of alcoholic beverages. This study aimed at conducting a macroscopic and microscopic analysis of the tissue response of tongue mucosa of hamsters to daily topical applications of antiseptics (Anapyon, Listerine, Oral B) during 13 and 20 weeks, following the methodology for carcinogenesis investigation developed by the Discipline of Pathology of Bauru Dental School, University of São Paulo. After sacrificing the animals, their tongues were removed and fixed on 10% formalin. Macroscopic examination did not reveal significant alterations, and the specimens were processed by routine histotechnical procedures for HE staining. Three serial sections of each tongue were evaluated, and characteristics related to epithelial hyperkeratinization, atrophy, hyperplasia and dysplasia were organized in tables. Despite the observation for moderate dysplasia in one case in the Anapyon 20 week group, the further results were very similar to the control group (saline solution), eliminating the need of comparative statistical tests. By means of such methodology for testing the carcinogenesis-initiating action, it was concluded that oral antiseptics are unable to trigger the development of neoplasms.
id USP-17_9c3c3e48b18517ee27570ed8b0718e50
oai_identifier_str oai:scielo:S1678-77572005000300016
network_acronym_str USP-17
network_name_str Journal of applied oral science (Online)
repository_id_str
spelling Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesisAlcoholOral antisepticsCarcinogenesisStudies have related the action of alcohol on the oral mucosa as a promoter of carcinogenesis, once most oral antiseptics contain alcohol. Its utilization for mouthrinses from 30 to 60 seconds, as indicated on the labels, yields a longer-lasting topical action when compared to the intake of alcoholic beverages. This study aimed at conducting a macroscopic and microscopic analysis of the tissue response of tongue mucosa of hamsters to daily topical applications of antiseptics (Anapyon, Listerine, Oral B) during 13 and 20 weeks, following the methodology for carcinogenesis investigation developed by the Discipline of Pathology of Bauru Dental School, University of São Paulo. After sacrificing the animals, their tongues were removed and fixed on 10% formalin. Macroscopic examination did not reveal significant alterations, and the specimens were processed by routine histotechnical procedures for HE staining. Three serial sections of each tongue were evaluated, and characteristics related to epithelial hyperkeratinization, atrophy, hyperplasia and dysplasia were organized in tables. Despite the observation for moderate dysplasia in one case in the Anapyon 20 week group, the further results were very similar to the control group (saline solution), eliminating the need of comparative statistical tests. By means of such methodology for testing the carcinogenesis-initiating action, it was concluded that oral antiseptics are unable to trigger the development of neoplasms.Faculdade De Odontologia De Bauru - USP2005-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000300016Journal of Applied Oral Science v.13 n.3 2005reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572005000300016info:eu-repo/semantics/openAccessCardoso,Camila LopesPrado,Renata Falchete doTaveira,Luís Antônio de Assiseng2005-10-24T00:00:00Zoai:scielo:S1678-77572005000300016Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2005-10-24T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
title Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
spellingShingle Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
Cardoso,Camila Lopes
Alcohol
Oral antiseptics
Carcinogenesis
title_short Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
title_full Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
title_fullStr Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
title_full_unstemmed Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
title_sort Macroscopic and microscopic study of tissue response to oral antiseptics and its influence on carcinigenesis
author Cardoso,Camila Lopes
author_facet Cardoso,Camila Lopes
Prado,Renata Falchete do
Taveira,Luís Antônio de Assis
author_role author
author2 Prado,Renata Falchete do
Taveira,Luís Antônio de Assis
author2_role author
author
dc.contributor.author.fl_str_mv Cardoso,Camila Lopes
Prado,Renata Falchete do
Taveira,Luís Antônio de Assis
dc.subject.por.fl_str_mv Alcohol
Oral antiseptics
Carcinogenesis
topic Alcohol
Oral antiseptics
Carcinogenesis
description Studies have related the action of alcohol on the oral mucosa as a promoter of carcinogenesis, once most oral antiseptics contain alcohol. Its utilization for mouthrinses from 30 to 60 seconds, as indicated on the labels, yields a longer-lasting topical action when compared to the intake of alcoholic beverages. This study aimed at conducting a macroscopic and microscopic analysis of the tissue response of tongue mucosa of hamsters to daily topical applications of antiseptics (Anapyon, Listerine, Oral B) during 13 and 20 weeks, following the methodology for carcinogenesis investigation developed by the Discipline of Pathology of Bauru Dental School, University of São Paulo. After sacrificing the animals, their tongues were removed and fixed on 10% formalin. Macroscopic examination did not reveal significant alterations, and the specimens were processed by routine histotechnical procedures for HE staining. Three serial sections of each tongue were evaluated, and characteristics related to epithelial hyperkeratinization, atrophy, hyperplasia and dysplasia were organized in tables. Despite the observation for moderate dysplasia in one case in the Anapyon 20 week group, the further results were very similar to the control group (saline solution), eliminating the need of comparative statistical tests. By means of such methodology for testing the carcinogenesis-initiating action, it was concluded that oral antiseptics are unable to trigger the development of neoplasms.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000300016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000300016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572005000300016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.13 n.3 2005
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1748936433920376832