Fructose and cardiometabolic disorders: the controversy will, and must, continue
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18343 |
Resumo: | The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growing industrial use as a sweetener, especially in soft drinks, has focused attention on its potential harmfulness, possibly leading to dyslipidemia, obesity, insulin resistance/metabolic syndrome and even diabetes. Many new data have been generated over the last years, confirming the lipogenic effect of fructose as well as risks of vascular dysfunction and hypertension. Fructose exerts various direct effects in the liver, affecting both hepatocytes and Kupffer cells and resulting in non-alcoholic steatotic hepatitis, a well known precursor of the metabolic syndrome. Hepatic metabolic abnormalities underlie indirect peripheral metabolic and vascular disturbances, for which uric acid is possibly the culprit. Nevertheless major caveats exist (species, gender, source of fructose, study protocols) which are detailed in this review and presently prevent any firm conclusion. New studies taking into account these confounding factors should be undertaken in order to ascertain whether or not high fructose diet is harmful. |
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Fructose and cardiometabolic disorders: the controversy will, and must, continue FructoseTriglyceridesMetabolic syndromeUric acidHypertensionDiet The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growing industrial use as a sweetener, especially in soft drinks, has focused attention on its potential harmfulness, possibly leading to dyslipidemia, obesity, insulin resistance/metabolic syndrome and even diabetes. Many new data have been generated over the last years, confirming the lipogenic effect of fructose as well as risks of vascular dysfunction and hypertension. Fructose exerts various direct effects in the liver, affecting both hepatocytes and Kupffer cells and resulting in non-alcoholic steatotic hepatitis, a well known precursor of the metabolic syndrome. Hepatic metabolic abnormalities underlie indirect peripheral metabolic and vascular disturbances, for which uric acid is possibly the culprit. Nevertheless major caveats exist (species, gender, source of fructose, study protocols) which are detailed in this review and presently prevent any firm conclusion. New studies taking into account these confounding factors should be undertaken in order to ascertain whether or not high fructose diet is harmful. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1834310.1590/S1807-59322010000700013Clinics; Vol. 65 No. 7 (2010); 729-738 Clinics; v. 65 n. 7 (2010); 729-738 Clinics; Vol. 65 Núm. 7 (2010); 729-738 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18343/20406Wiernsperger, NicolasGeloen, AlainRapin, Jean-Robertinfo:eu-repo/semantics/openAccess2012-05-23T11:15:07Zoai:revistas.usp.br:article/18343Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:15:07Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
title |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
spellingShingle |
Fructose and cardiometabolic disorders: the controversy will, and must, continue Wiernsperger, Nicolas Fructose Triglycerides Metabolic syndrome Uric acid Hypertension Diet |
title_short |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
title_full |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
title_fullStr |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
title_full_unstemmed |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
title_sort |
Fructose and cardiometabolic disorders: the controversy will, and must, continue |
author |
Wiernsperger, Nicolas |
author_facet |
Wiernsperger, Nicolas Geloen, Alain Rapin, Jean-Robert |
author_role |
author |
author2 |
Geloen, Alain Rapin, Jean-Robert |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Wiernsperger, Nicolas Geloen, Alain Rapin, Jean-Robert |
dc.subject.por.fl_str_mv |
Fructose Triglycerides Metabolic syndrome Uric acid Hypertension Diet |
topic |
Fructose Triglycerides Metabolic syndrome Uric acid Hypertension Diet |
description |
The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growing industrial use as a sweetener, especially in soft drinks, has focused attention on its potential harmfulness, possibly leading to dyslipidemia, obesity, insulin resistance/metabolic syndrome and even diabetes. Many new data have been generated over the last years, confirming the lipogenic effect of fructose as well as risks of vascular dysfunction and hypertension. Fructose exerts various direct effects in the liver, affecting both hepatocytes and Kupffer cells and resulting in non-alcoholic steatotic hepatitis, a well known precursor of the metabolic syndrome. Hepatic metabolic abnormalities underlie indirect peripheral metabolic and vascular disturbances, for which uric acid is possibly the culprit. Nevertheless major caveats exist (species, gender, source of fructose, study protocols) which are detailed in this review and presently prevent any firm conclusion. New studies taking into account these confounding factors should be undertaken in order to ascertain whether or not high fructose diet is harmful. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18343 10.1590/S1807-59322010000700013 |
url |
https://www.revistas.usp.br/clinics/article/view/18343 |
identifier_str_mv |
10.1590/S1807-59322010000700013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18343/20406 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 7 (2010); 729-738 Clinics; v. 65 n. 7 (2010); 729-738 Clinics; Vol. 65 Núm. 7 (2010); 729-738 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222754837889024 |