Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19366 |
Resumo: | BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy have not been previously studied. METHODS: Nine patients with type 2 diabetes mellitus and a body mass index ranging from 29 to 34.8 kg/m² underwent an entero-omentectomy procedure that consisted of an enterectomy of the middle jejunum and exeresis of the major part of the omentum performed through a mini-laparotomy. Glucagon-like peptide-1 and peptide YY were measured preoperatively and three months following the operation. Fasting and postprandial variations in glycemia, insulinemia, triglyceridemia, hemoglobin A1c, and body mass index were determined in the preoperative period and 3, 18 and, 36 months after the operation. RESULTS: All patients significantly improved the control of their type 2 diabetes mellitus. Postprandial secretion of peptide YY and Glucagon-like peptide-1 were enhanced, whereas hemoglobin A1c, fasting and postprandial glucose, insulin, and triglyceride levels were significantly reduced. Mean body mass index was reduced from 31.1 to 27.3 kg/m². No major surgical or nutritional complications occurred. CONCLUSIONS: Entero-omentectomy is easy and safe to perform. A simple reduction in jejunal extension and visceral fat causes important improvements in the metabolic profile. |
id |
USP-19_6df8e0a0f2dd5a2b3fcc38a20c723f57 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/19366 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years Type 2 diabetes mellitusGLP-1PYYEnterectomyOmentectomyMetabolic surgery BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy have not been previously studied. METHODS: Nine patients with type 2 diabetes mellitus and a body mass index ranging from 29 to 34.8 kg/m² underwent an entero-omentectomy procedure that consisted of an enterectomy of the middle jejunum and exeresis of the major part of the omentum performed through a mini-laparotomy. Glucagon-like peptide-1 and peptide YY were measured preoperatively and three months following the operation. Fasting and postprandial variations in glycemia, insulinemia, triglyceridemia, hemoglobin A1c, and body mass index were determined in the preoperative period and 3, 18 and, 36 months after the operation. RESULTS: All patients significantly improved the control of their type 2 diabetes mellitus. Postprandial secretion of peptide YY and Glucagon-like peptide-1 were enhanced, whereas hemoglobin A1c, fasting and postprandial glucose, insulin, and triglyceride levels were significantly reduced. Mean body mass index was reduced from 31.1 to 27.3 kg/m². No major surgical or nutritional complications occurred. CONCLUSIONS: Entero-omentectomy is easy and safe to perform. A simple reduction in jejunal extension and visceral fat causes important improvements in the metabolic profile. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1936610.1590/S1807-59322011000700018Clinics; Vol. 66 No. 7 (2011); 1227-1233 Clinics; v. 66 n. 7 (2011); 1227-1233 Clinics; Vol. 66 Núm. 7 (2011); 1227-1233 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19366/21429Milleo, Fábio QuiriloCampos, Antonio Carlos LigockiSantoro, SérgioLacombe, ArnaldoSanto, Marco AurélioVicari, Marcelo RicardoNogaroto, VivianeArtoni, Roberto Ferreirainfo:eu-repo/semantics/openAccess2012-05-23T16:36:31Zoai:revistas.usp.br:article/19366Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:36:31Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
title |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
spellingShingle |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years Milleo, Fábio Quirilo Type 2 diabetes mellitus GLP-1 PYY Enterectomy Omentectomy Metabolic surgery |
title_short |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
title_full |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
title_fullStr |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
title_full_unstemmed |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
title_sort |
Metabolic effects of an entero-omentectomy in mildly obese type 2 diabetes mellitus patients after three years |
author |
Milleo, Fábio Quirilo |
author_facet |
Milleo, Fábio Quirilo Campos, Antonio Carlos Ligocki Santoro, Sérgio Lacombe, Arnaldo Santo, Marco Aurélio Vicari, Marcelo Ricardo Nogaroto, Viviane Artoni, Roberto Ferreira |
author_role |
author |
author2 |
Campos, Antonio Carlos Ligocki Santoro, Sérgio Lacombe, Arnaldo Santo, Marco Aurélio Vicari, Marcelo Ricardo Nogaroto, Viviane Artoni, Roberto Ferreira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Milleo, Fábio Quirilo Campos, Antonio Carlos Ligocki Santoro, Sérgio Lacombe, Arnaldo Santo, Marco Aurélio Vicari, Marcelo Ricardo Nogaroto, Viviane Artoni, Roberto Ferreira |
dc.subject.por.fl_str_mv |
Type 2 diabetes mellitus GLP-1 PYY Enterectomy Omentectomy Metabolic surgery |
topic |
Type 2 diabetes mellitus GLP-1 PYY Enterectomy Omentectomy Metabolic surgery |
description |
BACKGROUND: Various digestive tract procedures effectively improve metabolic syndrome, especially the control of type 2 diabetes mellitus. Very good metabolic results have been shown with vertical gastrectomy and entero-omentectomy; however, the metabolic effects of an isolated entero-omentectomy have not been previously studied. METHODS: Nine patients with type 2 diabetes mellitus and a body mass index ranging from 29 to 34.8 kg/m² underwent an entero-omentectomy procedure that consisted of an enterectomy of the middle jejunum and exeresis of the major part of the omentum performed through a mini-laparotomy. Glucagon-like peptide-1 and peptide YY were measured preoperatively and three months following the operation. Fasting and postprandial variations in glycemia, insulinemia, triglyceridemia, hemoglobin A1c, and body mass index were determined in the preoperative period and 3, 18 and, 36 months after the operation. RESULTS: All patients significantly improved the control of their type 2 diabetes mellitus. Postprandial secretion of peptide YY and Glucagon-like peptide-1 were enhanced, whereas hemoglobin A1c, fasting and postprandial glucose, insulin, and triglyceride levels were significantly reduced. Mean body mass index was reduced from 31.1 to 27.3 kg/m². No major surgical or nutritional complications occurred. CONCLUSIONS: Entero-omentectomy is easy and safe to perform. A simple reduction in jejunal extension and visceral fat causes important improvements in the metabolic profile. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19366 10.1590/S1807-59322011000700018 |
url |
https://www.revistas.usp.br/clinics/article/view/19366 |
identifier_str_mv |
10.1590/S1807-59322011000700018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19366/21429 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 7 (2011); 1227-1233 Clinics; v. 66 n. 7 (2011); 1227-1233 Clinics; Vol. 66 Núm. 7 (2011); 1227-1233 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222756842766336 |