Oxidative stress and immune system analysis after cycle ergometer use in critical patients
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/130843 |
Resumo: | OBJECTIVE: The passive cycle ergometer aims to prevent hypotrophy and improve muscle strength, with a consequent reduction in hospitalization time in the intensive care unit and functional improvement. However, its effects on oxidative stress and immune system parameters remain unknown. The aim of this study is to analyze the effects of a passive cycle ergometer on the immune system and oxidative stress in critical patients. METHODS: This paper describes a randomized controlled trial in a sample of 19 patients of both genders who were on mechanical ventilation and hospitalized in the intensive care unit of the Hospital Agamenom Magalhães. The patients were divided into two groups: one group underwent cycle ergometer passive exercise for 30 cycles/min on the lower limbs for 20 minutes; the other group did not undergo any therapeutic intervention during the study and served as the control group. A total of 20 ml of blood was analysed, in which nitric oxide levels and some specific inflammatory cytokines (tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukins 6 (IL-6) and 10 (IL-10)) were evaluated before and after the study protocol. RESULTS: Regarding the demographic and clinical variables, the groups were homogeneous in the early phases of the study. The nitric oxide analysis revealed a reduction in nitric oxide variation in stimulated cells (p=0.0021) and those stimulated (p=0.0076) after passive cycle ergometer use compared to the control group. No differences in the evaluated inflammatory cytokines were observed between the two groups. CONCLUSION: We can conclude that the passive cycle ergometer promoted reduced levels of nitric oxide, showing beneficial effects on oxidative stress reduction. As assessed by inflammatory cytokines, the treatment was not associated with changes in the immune system. However, further research in a larger population is necessary for more conclusive results. |
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oai:revistas.usp.br:article/130843 |
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Clinics |
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Oxidative stress and immune system analysis after cycle ergometer use in critical patientsCytokinesOxidative stressMusculoskeletal abnormalitiesOBJECTIVE: The passive cycle ergometer aims to prevent hypotrophy and improve muscle strength, with a consequent reduction in hospitalization time in the intensive care unit and functional improvement. However, its effects on oxidative stress and immune system parameters remain unknown. The aim of this study is to analyze the effects of a passive cycle ergometer on the immune system and oxidative stress in critical patients. METHODS: This paper describes a randomized controlled trial in a sample of 19 patients of both genders who were on mechanical ventilation and hospitalized in the intensive care unit of the Hospital Agamenom Magalhães. The patients were divided into two groups: one group underwent cycle ergometer passive exercise for 30 cycles/min on the lower limbs for 20 minutes; the other group did not undergo any therapeutic intervention during the study and served as the control group. A total of 20 ml of blood was analysed, in which nitric oxide levels and some specific inflammatory cytokines (tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukins 6 (IL-6) and 10 (IL-10)) were evaluated before and after the study protocol. RESULTS: Regarding the demographic and clinical variables, the groups were homogeneous in the early phases of the study. The nitric oxide analysis revealed a reduction in nitric oxide variation in stimulated cells (p=0.0021) and those stimulated (p=0.0076) after passive cycle ergometer use compared to the control group. No differences in the evaluated inflammatory cytokines were observed between the two groups. CONCLUSION: We can conclude that the passive cycle ergometer promoted reduced levels of nitric oxide, showing beneficial effects on oxidative stress reduction. As assessed by inflammatory cytokines, the treatment was not associated with changes in the immune system. However, further research in a larger population is necessary for more conclusive results.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/13084310.6061/clinics/2017(03)03Clinics; Vol. 72 No. 3 (2017); 143-149Clinics; v. 72 n. 3 (2017); 143-149Clinics; Vol. 72 Núm. 3 (2017); 143-1491980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/130843/127282Copyright (c) 2017 Clinicsinfo:eu-repo/semantics/openAccessFrança, Eduardo Eriko Tenório deRibeiro, Luana CarneiroLamenha, Gabriela GomesMagalhães, Isabela Kalline FidelixFigueiredo, Thainá de GomesCosta, Marthley José CorreiaElihimas Júnior, Ubiracé FernandoFeitosa, Bárbara LuanaAndrade, Maria do AmparoCorreia Júnior, Marco Aurélio ValoisRamos, Francimar FerrariCastro, Célia Maria Machado Barbosa de2017-04-10T16:00:51Zoai:revistas.usp.br:article/130843Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2017-04-10T16:00:51Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
title |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
spellingShingle |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients França, Eduardo Eriko Tenório de Cytokines Oxidative stress Musculoskeletal abnormalities |
title_short |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
title_full |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
title_fullStr |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
title_full_unstemmed |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
title_sort |
Oxidative stress and immune system analysis after cycle ergometer use in critical patients |
author |
França, Eduardo Eriko Tenório de |
author_facet |
França, Eduardo Eriko Tenório de Ribeiro, Luana Carneiro Lamenha, Gabriela Gomes Magalhães, Isabela Kalline Fidelix Figueiredo, Thainá de Gomes Costa, Marthley José Correia Elihimas Júnior, Ubiracé Fernando Feitosa, Bárbara Luana Andrade, Maria do Amparo Correia Júnior, Marco Aurélio Valois Ramos, Francimar Ferrari Castro, Célia Maria Machado Barbosa de |
author_role |
author |
author2 |
Ribeiro, Luana Carneiro Lamenha, Gabriela Gomes Magalhães, Isabela Kalline Fidelix Figueiredo, Thainá de Gomes Costa, Marthley José Correia Elihimas Júnior, Ubiracé Fernando Feitosa, Bárbara Luana Andrade, Maria do Amparo Correia Júnior, Marco Aurélio Valois Ramos, Francimar Ferrari Castro, Célia Maria Machado Barbosa de |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
França, Eduardo Eriko Tenório de Ribeiro, Luana Carneiro Lamenha, Gabriela Gomes Magalhães, Isabela Kalline Fidelix Figueiredo, Thainá de Gomes Costa, Marthley José Correia Elihimas Júnior, Ubiracé Fernando Feitosa, Bárbara Luana Andrade, Maria do Amparo Correia Júnior, Marco Aurélio Valois Ramos, Francimar Ferrari Castro, Célia Maria Machado Barbosa de |
dc.subject.por.fl_str_mv |
Cytokines Oxidative stress Musculoskeletal abnormalities |
topic |
Cytokines Oxidative stress Musculoskeletal abnormalities |
description |
OBJECTIVE: The passive cycle ergometer aims to prevent hypotrophy and improve muscle strength, with a consequent reduction in hospitalization time in the intensive care unit and functional improvement. However, its effects on oxidative stress and immune system parameters remain unknown. The aim of this study is to analyze the effects of a passive cycle ergometer on the immune system and oxidative stress in critical patients. METHODS: This paper describes a randomized controlled trial in a sample of 19 patients of both genders who were on mechanical ventilation and hospitalized in the intensive care unit of the Hospital Agamenom Magalhães. The patients were divided into two groups: one group underwent cycle ergometer passive exercise for 30 cycles/min on the lower limbs for 20 minutes; the other group did not undergo any therapeutic intervention during the study and served as the control group. A total of 20 ml of blood was analysed, in which nitric oxide levels and some specific inflammatory cytokines (tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukins 6 (IL-6) and 10 (IL-10)) were evaluated before and after the study protocol. RESULTS: Regarding the demographic and clinical variables, the groups were homogeneous in the early phases of the study. The nitric oxide analysis revealed a reduction in nitric oxide variation in stimulated cells (p=0.0021) and those stimulated (p=0.0076) after passive cycle ergometer use compared to the control group. No differences in the evaluated inflammatory cytokines were observed between the two groups. CONCLUSION: We can conclude that the passive cycle ergometer promoted reduced levels of nitric oxide, showing beneficial effects on oxidative stress reduction. As assessed by inflammatory cytokines, the treatment was not associated with changes in the immune system. However, further research in a larger population is necessary for more conclusive results. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/130843 10.6061/clinics/2017(03)03 |
url |
https://www.revistas.usp.br/clinics/article/view/130843 |
identifier_str_mv |
10.6061/clinics/2017(03)03 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/130843/127282 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 72 No. 3 (2017); 143-149 Clinics; v. 72 n. 3 (2017); 143-149 Clinics; Vol. 72 Núm. 3 (2017); 143-149 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763132125184 |