Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges

Detalhes bibliográficos
Autor(a) principal: Liu, Yanfen
Data de Publicação: 2020
Outros Autores: Lou, Xueyong
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/165898
Resumo: The gut microbiota is a group of over 38 trillion bacterial cells in the human microbiota that plays an important role in the regulation of human metabolism through its symbiotic relationship with the host. Changes in the gut microbial ecosystem are associated with increased susceptibility to metabolic disease in humans. However, the composition of the gut microbiota in those with type 2 diabetes mellitus and in the pathogenesis of metabolic diseases is not well understood. This article reviews the relationship between environmental factors and the gut microbiota in individuals with type 2 diabetes mellitus. Finally, we discuss the goal of treating type 2 diabetes mellitus by modifying the gut microbiota and the challenges that remain in this area.
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spelling Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challengesType 2 Diabetes MellitusGut MicrobiotaEnvironmental FactorsThe gut microbiota is a group of over 38 trillion bacterial cells in the human microbiota that plays an important role in the regulation of human metabolism through its symbiotic relationship with the host. Changes in the gut microbial ecosystem are associated with increased susceptibility to metabolic disease in humans. However, the composition of the gut microbiota in those with type 2 diabetes mellitus and in the pathogenesis of metabolic diseases is not well understood. This article reviews the relationship between environmental factors and the gut microbiota in individuals with type 2 diabetes mellitus. Finally, we discuss the goal of treating type 2 diabetes mellitus by modifying the gut microbiota and the challenges that remain in this area.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-01-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16589810.6061/clinics/2020/e1277Clinics; Vol. 75 (2020); e1277Clinics; v. 75 (2020); e1277Clinics; Vol. 75 (2020); e12771980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/165898/158763https://www.revistas.usp.br/clinics/article/view/165898/159728Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessLiu, YanfenLou, Xueyong2020-01-22T14:29:33Zoai:revistas.usp.br:article/165898Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-01-22T14:29:33Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
title Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
spellingShingle Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
Liu, Yanfen
Type 2 Diabetes Mellitus
Gut Microbiota
Environmental Factors
title_short Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
title_full Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
title_fullStr Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
title_full_unstemmed Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
title_sort Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges
author Liu, Yanfen
author_facet Liu, Yanfen
Lou, Xueyong
author_role author
author2 Lou, Xueyong
author2_role author
dc.contributor.author.fl_str_mv Liu, Yanfen
Lou, Xueyong
dc.subject.por.fl_str_mv Type 2 Diabetes Mellitus
Gut Microbiota
Environmental Factors
topic Type 2 Diabetes Mellitus
Gut Microbiota
Environmental Factors
description The gut microbiota is a group of over 38 trillion bacterial cells in the human microbiota that plays an important role in the regulation of human metabolism through its symbiotic relationship with the host. Changes in the gut microbial ecosystem are associated with increased susceptibility to metabolic disease in humans. However, the composition of the gut microbiota in those with type 2 diabetes mellitus and in the pathogenesis of metabolic diseases is not well understood. This article reviews the relationship between environmental factors and the gut microbiota in individuals with type 2 diabetes mellitus. Finally, we discuss the goal of treating type 2 diabetes mellitus by modifying the gut microbiota and the challenges that remain in this area.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/165898
10.6061/clinics/2020/e1277
url https://www.revistas.usp.br/clinics/article/view/165898
identifier_str_mv 10.6061/clinics/2020/e1277
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/165898/158763
https://www.revistas.usp.br/clinics/article/view/165898/159728
dc.rights.driver.fl_str_mv Copyright (c) 2020 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 75 (2020); e1277
Clinics; v. 75 (2020); e1277
Clinics; Vol. 75 (2020); e1277
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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