Protective effects of Tualang honey on bone structure in experimental postmenopausal rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/40154 |
Resumo: | OBJECTIVE: The objective of this study was to evaluate the effects of Tualang honey on trabecular structure and compare these effects with those of calcium supplementation in ovariectomized rats. METHODS: Forty female, Sprague-Dawley rats were randomly divided into five groups (n =8): four controls and one test arm. The control arm comprised a baseline control, sham-operated control, ovariectomized control, and ovariectomized calcium-treated rats (receiving 1% calcium in drinking water ad libitum). The test arm was composed of ovariectomized, Tualang honey-treated rats (received 0.2 g/kg body weight of Tualang honey). Both the sham-operated control and ovariectomized control groups received vehicle treatment (deionized water), and the baseline control group was sacrificed without treatment. RESULTS: All rats were orally gavaged daily for six weeks after day one post-surgery. The bone structural analysis of rats in the test arm group showed a significant increase in the bone volume per tissue volume (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N) and a significant decrease in inter-trabecular space (Tb.Sp) compared with the ovariectomized control group. The trabecular thickness (Tb.Th) in the test arm group was significantly higher compared with the ovariectomized-calcium treated group, and the inter-trabecular space (Tb.Sp) in the test arm group was significantly narrower compared with the ovariectomized-calcium treated group. CONCLUSION: In conclusion, ovariectomized rats that received Tualang honey showed more improvements in trabecular bone structure than the rats that received calcium. |
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oai:revistas.usp.br:article/40154 |
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Clinics |
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Protective effects of Tualang honey on bone structure in experimental postmenopausal ratsTualang honeyOvariectomyOsteoporosisTrabecularStructuralOBJECTIVE: The objective of this study was to evaluate the effects of Tualang honey on trabecular structure and compare these effects with those of calcium supplementation in ovariectomized rats. METHODS: Forty female, Sprague-Dawley rats were randomly divided into five groups (n =8): four controls and one test arm. The control arm comprised a baseline control, sham-operated control, ovariectomized control, and ovariectomized calcium-treated rats (receiving 1% calcium in drinking water ad libitum). The test arm was composed of ovariectomized, Tualang honey-treated rats (received 0.2 g/kg body weight of Tualang honey). Both the sham-operated control and ovariectomized control groups received vehicle treatment (deionized water), and the baseline control group was sacrificed without treatment. RESULTS: All rats were orally gavaged daily for six weeks after day one post-surgery. The bone structural analysis of rats in the test arm group showed a significant increase in the bone volume per tissue volume (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N) and a significant decrease in inter-trabecular space (Tb.Sp) compared with the ovariectomized control group. The trabecular thickness (Tb.Th) in the test arm group was significantly higher compared with the ovariectomized-calcium treated group, and the inter-trabecular space (Tb.Sp) in the test arm group was significantly narrower compared with the ovariectomized-calcium treated group. CONCLUSION: In conclusion, ovariectomized rats that received Tualang honey showed more improvements in trabecular bone structure than the rats that received calcium.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4015410.6061/clinics/2012(07)13Clinics; Vol. 67 No. 7 (2012); 779-784Clinics; v. 67 n. 7 (2012); 779-784Clinics; Vol. 67 Núm. 7 (2012); 779-7841980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/40154/43020Zaid, Siti Sarah MohamadSulaiman, Siti AmrahOthman, Nor HayatiSoelaiman, Ima-NirwanaShuid, Ahmad NazrunMohamad, NorazlinaMuhamad, Norlizainfo:eu-repo/semantics/openAccess2012-08-23T18:32:01Zoai:revistas.usp.br:article/40154Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-08-23T18:32:01Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
title |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
spellingShingle |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats Zaid, Siti Sarah Mohamad Tualang honey Ovariectomy Osteoporosis Trabecular Structural |
title_short |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
title_full |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
title_fullStr |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
title_full_unstemmed |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
title_sort |
Protective effects of Tualang honey on bone structure in experimental postmenopausal rats |
author |
Zaid, Siti Sarah Mohamad |
author_facet |
Zaid, Siti Sarah Mohamad Sulaiman, Siti Amrah Othman, Nor Hayati Soelaiman, Ima-Nirwana Shuid, Ahmad Nazrun Mohamad, Norazlina Muhamad, Norliza |
author_role |
author |
author2 |
Sulaiman, Siti Amrah Othman, Nor Hayati Soelaiman, Ima-Nirwana Shuid, Ahmad Nazrun Mohamad, Norazlina Muhamad, Norliza |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Zaid, Siti Sarah Mohamad Sulaiman, Siti Amrah Othman, Nor Hayati Soelaiman, Ima-Nirwana Shuid, Ahmad Nazrun Mohamad, Norazlina Muhamad, Norliza |
dc.subject.por.fl_str_mv |
Tualang honey Ovariectomy Osteoporosis Trabecular Structural |
topic |
Tualang honey Ovariectomy Osteoporosis Trabecular Structural |
description |
OBJECTIVE: The objective of this study was to evaluate the effects of Tualang honey on trabecular structure and compare these effects with those of calcium supplementation in ovariectomized rats. METHODS: Forty female, Sprague-Dawley rats were randomly divided into five groups (n =8): four controls and one test arm. The control arm comprised a baseline control, sham-operated control, ovariectomized control, and ovariectomized calcium-treated rats (receiving 1% calcium in drinking water ad libitum). The test arm was composed of ovariectomized, Tualang honey-treated rats (received 0.2 g/kg body weight of Tualang honey). Both the sham-operated control and ovariectomized control groups received vehicle treatment (deionized water), and the baseline control group was sacrificed without treatment. RESULTS: All rats were orally gavaged daily for six weeks after day one post-surgery. The bone structural analysis of rats in the test arm group showed a significant increase in the bone volume per tissue volume (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N) and a significant decrease in inter-trabecular space (Tb.Sp) compared with the ovariectomized control group. The trabecular thickness (Tb.Th) in the test arm group was significantly higher compared with the ovariectomized-calcium treated group, and the inter-trabecular space (Tb.Sp) in the test arm group was significantly narrower compared with the ovariectomized-calcium treated group. CONCLUSION: In conclusion, ovariectomized rats that received Tualang honey showed more improvements in trabecular bone structure than the rats that received calcium. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/40154 10.6061/clinics/2012(07)13 |
url |
https://www.revistas.usp.br/clinics/article/view/40154 |
identifier_str_mv |
10.6061/clinics/2012(07)13 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/40154/43020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 7 (2012); 779-784 Clinics; v. 67 n. 7 (2012); 779-784 Clinics; Vol. 67 Núm. 7 (2012); 779-784 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222758735446016 |