Frequency of the mdr-1 C>;T gene polymorphism in patients with COPD

• Autor(a) principal: Dogan, Ömer Tamer
• Data de Publicação: 2010
• Outros Autores: Katrancioglu, Nurkay, Karahan, Ouz, Sanli, Gülizar Canan, Zorlu, Ali, Manduz, Şinasi
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/18490
• topic: COPD; MDR-1 gene; T allele frequency; Transporter glycoprotein; Reverse-hybridization

BACKGROUND AND AIM: The multi-drug resistant-1 (MDR-1) gene is located on human chromosome 7 and encodes a glycosylated membrane protein that is a member of the ATP-binding cassette transporters superfamily. The aim of the study was to reveal the role of the C3435T MDR-1 gene polymorphism in chronic obstructive pulmonary disease. METHOD: DNA samples from 41 patients with chronic obstructive pulmonary disease and 50 healthy control participants were used to compare MDR-1 gene profiles. Genotyping assays were performed using the StripAssay technique that is based on reverse-hybridization. RESULTS: The T allele polymorphism in the MDR-1 gene located at position 3435 in exon 26 was shown to correlate with chronic obstructive pulmonary disease. CONCLUSION: These preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with chronic obstructive pulmonary disease.