Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition

• Autor(a) principal: Stein, Anna
• Data de Publicação: 2012
• Outros Autores: Goldmeier, Silvia, Voltolini, Sarah, Setogutti, Enio, Feldman, Carlos, Figueiredo, Eduardo, Eick, Renato, Irigoyen, Maria, Rigatto, Katya
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/40151
• topic: BOLD; Renal Oxygenation; Healthy Subjects; Captopril; Renin-Angiotensin System

OBJECTIVE: The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients. METHOD: R2* quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50±5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2*/T2* images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2* maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean + standard deviation) followed by the Tukey test. ClinicalTrials.gov: NCT01545479. RESULTS: A significant difference (p