Drug-related toxic events in the state of São Paulo, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/32173 |
Resumo: | OBJECTIVE: To assess the epidemiological characteristics of drug-related toxic events in the State of São Paulo, Brazil. METHODS: A descriptive epidemiological case series study was conducted. Using the category "drug-related toxic event", 6,673 registered cases were analyzed in the Toxicology Centers in the State of São Paulo throughout 1998. The variables studied comprised the characteristics of the events and the affected patients, toxic agents and the circumstances involved. The analysis of toxic agents took into consideration three levels of disaggregation: therapeutical groups, active ingredients and commercial brand names. RESULTS: Drugs ranked first among all toxic agents registered in the Centers. Drug-related toxic events were mostly reported by phone (78.5%) and hospitals (86.6%); they were originated from acute oral exposure (90.2%) at home (85.7%) in the urban area (95%). Most people affected were females (59%) in their first decade of life (49.4%), mainly between two and three years of age. The most common active ingredients found were: phenobarbital, diazepam, haloperidol, carbamazepine and bromazepam. The main circumstances were accidental ingestion (38.8%) and suicidal attempts (36.5%) and among the related active ingredients, the most prevailing therapeutical group were psychiatric, analgesic/anesthetic and respiratory. CONCLUSIONS: Law-abiding practices regarding prescription drugs are needed, as well as toxicological surveillance according to the National Health System guidelines. |
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Drug-related toxic events in the state of São Paulo, Brazil Eventos toxicológicos relacionados a medicamentos no Estado de São Paulo IntoxicaçãoToxicidade de drogasPreparações farmacêuticas^i1^sefeitos adverUso de medicamentosCentros de controle de intoxicaçõesCentros de informaçõesVigilância sanitáriaMedicamentoPoisoningDrug toxicityPharmaceutical preparations^i2^sadverse effeDrug utilizationPoison control centersInformation centersHealth surveillanceDrugs OBJECTIVE: To assess the epidemiological characteristics of drug-related toxic events in the State of São Paulo, Brazil. METHODS: A descriptive epidemiological case series study was conducted. Using the category "drug-related toxic event", 6,673 registered cases were analyzed in the Toxicology Centers in the State of São Paulo throughout 1998. The variables studied comprised the characteristics of the events and the affected patients, toxic agents and the circumstances involved. The analysis of toxic agents took into consideration three levels of disaggregation: therapeutical groups, active ingredients and commercial brand names. RESULTS: Drugs ranked first among all toxic agents registered in the Centers. Drug-related toxic events were mostly reported by phone (78.5%) and hospitals (86.6%); they were originated from acute oral exposure (90.2%) at home (85.7%) in the urban area (95%). Most people affected were females (59%) in their first decade of life (49.4%), mainly between two and three years of age. The most common active ingredients found were: phenobarbital, diazepam, haloperidol, carbamazepine and bromazepam. The main circumstances were accidental ingestion (38.8%) and suicidal attempts (36.5%) and among the related active ingredients, the most prevailing therapeutical group were psychiatric, analgesic/anesthetic and respiratory. CONCLUSIONS: Law-abiding practices regarding prescription drugs are needed, as well as toxicological surveillance according to the National Health System guidelines. OBJETIVO: Analisar as características epidemiológicas dos eventos toxicológicos relacionados a medicamentos. MÉTODOS: Realizou-se um estudo epidemiológico descritivo de série de casos. Utilizando a categoria "evento toxicológico relacionado a medicamentos", analisaram-se 6.673 casos registrados em centros de assistência toxicológica do Estado de São Paulo, no ano de 1998. As variáveis estudadas compreenderam características dos eventos, das pessoas afetadas, dos agentes tóxicos e das circunstâncias envolvidas. A análise dos agentes tóxicos considerou três níveis de desagregação: grupos terapêuticos, princípios ativos e nomes comerciais. RESULTADOS: Os medicamentos ocuparam o primeiro lugar entre todos os tipos de agentes tóxicos registrados pelos centros. Os eventos toxicológicos relacionados a medicamentos caracterizaram-se por serem registrados por telefone (78,5%), a partir de hospitais (86,6%); originaram-se de exposições agudas, pela via oral (90,2%), ocorridas em residência (85,7%) de área urbana (95%). Houve predomínio do sexo feminino (59%) e maior concentração na primeira década de vida (49,4%), sobretudo aos dois e três anos de idade. Os princípios ativos mais freqüentemente encontrados foram: fenobarbital, diazepam, haloperidol, carbamazepina e bromazepam. As principais circunstâncias foram as acidentais (38,8%) e tentativas de suicídio (36,5%). Entre os princípios ativos relacionados predominaram os dos grupos terapêuticos psiquiatria, analgesia/anestesia e respiratório. CONCLUSÕES: Aponta-se a necessidade de cumprimento da legislação quanto à venda de medicamentos sob receituário médico e de construção da toxicovigilância conforme diretrizes do Sistema Único de Saúde. Universidade de São Paulo. Faculdade de Saúde Pública2006-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3217310.1590/S0034-89102006000700014Revista de Saúde Pública; Vol. 40 No. 6 (2006); 1056-1064 Revista de Saúde Pública; Vol. 40 Núm. 6 (2006); 1056-1064 Revista de Saúde Pública; v. 40 n. 6 (2006); 1056-1064 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/32173/34270Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessGandolfi, ElianeAndrade, Maria da Graça Garcia2012-07-08T23:17:01Zoai:revistas.usp.br:article/32173Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-08T23:17:01Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Drug-related toxic events in the state of São Paulo, Brazil Eventos toxicológicos relacionados a medicamentos no Estado de São Paulo |
title |
Drug-related toxic events in the state of São Paulo, Brazil |
spellingShingle |
Drug-related toxic events in the state of São Paulo, Brazil Gandolfi, Eliane Intoxicação Toxicidade de drogas Preparações farmacêuticas^i1^sefeitos adver Uso de medicamentos Centros de controle de intoxicações Centros de informações Vigilância sanitária Medicamento Poisoning Drug toxicity Pharmaceutical preparations^i2^sadverse effe Drug utilization Poison control centers Information centers Health surveillance Drugs |
title_short |
Drug-related toxic events in the state of São Paulo, Brazil |
title_full |
Drug-related toxic events in the state of São Paulo, Brazil |
title_fullStr |
Drug-related toxic events in the state of São Paulo, Brazil |
title_full_unstemmed |
Drug-related toxic events in the state of São Paulo, Brazil |
title_sort |
Drug-related toxic events in the state of São Paulo, Brazil |
author |
Gandolfi, Eliane |
author_facet |
Gandolfi, Eliane Andrade, Maria da Graça Garcia |
author_role |
author |
author2 |
Andrade, Maria da Graça Garcia |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Gandolfi, Eliane Andrade, Maria da Graça Garcia |
dc.subject.por.fl_str_mv |
Intoxicação Toxicidade de drogas Preparações farmacêuticas^i1^sefeitos adver Uso de medicamentos Centros de controle de intoxicações Centros de informações Vigilância sanitária Medicamento Poisoning Drug toxicity Pharmaceutical preparations^i2^sadverse effe Drug utilization Poison control centers Information centers Health surveillance Drugs |
topic |
Intoxicação Toxicidade de drogas Preparações farmacêuticas^i1^sefeitos adver Uso de medicamentos Centros de controle de intoxicações Centros de informações Vigilância sanitária Medicamento Poisoning Drug toxicity Pharmaceutical preparations^i2^sadverse effe Drug utilization Poison control centers Information centers Health surveillance Drugs |
description |
OBJECTIVE: To assess the epidemiological characteristics of drug-related toxic events in the State of São Paulo, Brazil. METHODS: A descriptive epidemiological case series study was conducted. Using the category "drug-related toxic event", 6,673 registered cases were analyzed in the Toxicology Centers in the State of São Paulo throughout 1998. The variables studied comprised the characteristics of the events and the affected patients, toxic agents and the circumstances involved. The analysis of toxic agents took into consideration three levels of disaggregation: therapeutical groups, active ingredients and commercial brand names. RESULTS: Drugs ranked first among all toxic agents registered in the Centers. Drug-related toxic events were mostly reported by phone (78.5%) and hospitals (86.6%); they were originated from acute oral exposure (90.2%) at home (85.7%) in the urban area (95%). Most people affected were females (59%) in their first decade of life (49.4%), mainly between two and three years of age. The most common active ingredients found were: phenobarbital, diazepam, haloperidol, carbamazepine and bromazepam. The main circumstances were accidental ingestion (38.8%) and suicidal attempts (36.5%) and among the related active ingredients, the most prevailing therapeutical group were psychiatric, analgesic/anesthetic and respiratory. CONCLUSIONS: Law-abiding practices regarding prescription drugs are needed, as well as toxicological surveillance according to the National Health System guidelines. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/32173 10.1590/S0034-89102006000700014 |
url |
https://www.revistas.usp.br/rsp/article/view/32173 |
identifier_str_mv |
10.1590/S0034-89102006000700014 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/32173/34270 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 40 No. 6 (2006); 1056-1064 Revista de Saúde Pública; Vol. 40 Núm. 6 (2006); 1056-1064 Revista de Saúde Pública; v. 40 n. 6 (2006); 1056-1064 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
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1800221785388482560 |