Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides

Detalhes bibliográficos
Autor(a) principal: Upadhyay, Jyoti
Data de Publicação: 2019
Outros Autores: Rana, Mahendra, Bisht, Satpal Singh, Rana, Amita, Durgapal, Sumit, Juyal, Vijay
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/160819
Resumo: Experiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure.
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spelling Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticidesGlyphosate, CarbendazimBiomarker responsesBiomarkers/ analysisPesticide exposure/ histopathologyNewborn/ histopathologyHerbicides/ toxicityExperiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-08-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16081910.1590/s2175-97902019000118194Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18194Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18194Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e181942175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/160819/154991Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessUpadhyay, JyotiRana, MahendraBisht, Satpal SinghRana, AmitaDurgapal, SumitJuyal, Vijay2021-01-11T17:32:19Zoai:revistas.usp.br:article/160819Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-11T17:32:19Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
title Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
spellingShingle Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
Upadhyay, Jyoti
Glyphosate, Carbendazim
Biomarker responses
Biomarkers/ analysis
Pesticide exposure/ histopathology
Newborn/ histopathology
Herbicides/ toxicity
title_short Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
title_full Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
title_fullStr Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
title_full_unstemmed Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
title_sort Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides
author Upadhyay, Jyoti
author_facet Upadhyay, Jyoti
Rana, Mahendra
Bisht, Satpal Singh
Rana, Amita
Durgapal, Sumit
Juyal, Vijay
author_role author
author2 Rana, Mahendra
Bisht, Satpal Singh
Rana, Amita
Durgapal, Sumit
Juyal, Vijay
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Upadhyay, Jyoti
Rana, Mahendra
Bisht, Satpal Singh
Rana, Amita
Durgapal, Sumit
Juyal, Vijay
dc.subject.por.fl_str_mv Glyphosate, Carbendazim
Biomarker responses
Biomarkers/ analysis
Pesticide exposure/ histopathology
Newborn/ histopathology
Herbicides/ toxicity
topic Glyphosate, Carbendazim
Biomarker responses
Biomarkers/ analysis
Pesticide exposure/ histopathology
Newborn/ histopathology
Herbicides/ toxicity
description Experiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/160819
10.1590/s2175-97902019000118194
url https://www.revistas.usp.br/bjps/article/view/160819
identifier_str_mv 10.1590/s2175-97902019000118194
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/160819/154991
dc.rights.driver.fl_str_mv Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18194
Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18194
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18194
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1800222914424864768

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