Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/210968 |
Resumo: | Diabetes is a metabolic disorder caused by insulin resistance or a defect in the pancreatic beta cells in insulin secretion. The aim of this study was to evaluate the possible effectiveness of long-term administration of resveratrol on inflammatory and oxidative stress markers in the pancreatic tissue of diabetic rats. Male Wistar rats (n = 24) were randomly divided into four groups of six animals, namely a healthy group, a healthy group receiving resveratrol, a diabetic control group, and a diabetic group receiving resveratrol. Diabetes was induced by single dose injection of streptozotocin (50 mg/kg; ip), 15 min after injection of nicotinamide (110 mg/kg; ip). Resveratrol was also administered by gavage (5 mg/kg/day) for 4 months. Administration of resveratrol alleviated hyperglycemia, weight loss and pancreatic β cell function measured by HOMA-β. Resveratrol improved oxidative stress (nitrate/nitrite, 8-isoprostane and glutathione) and proinflammatory markers (tumor necrosis factor α, cyclooxygenase 2, interleukin 6 and nuclear factor kappa B) in the pancreatic tissue of diabetic rats. Resveratrol administration had no significant effect on the activity of superoxide dismutase and catalase enzyme. These observations indicate that resveratrol administration may be effective as a beneficial factor in improving pancreatic function and reducing the complications of diabetes. |
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Brazilian Journal of Pharmaceutical Sciences |
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Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male ratsHyperglycemia HOMA-βIL-6NF-κBResveratrolTNF-αDiabetes is a metabolic disorder caused by insulin resistance or a defect in the pancreatic beta cells in insulin secretion. The aim of this study was to evaluate the possible effectiveness of long-term administration of resveratrol on inflammatory and oxidative stress markers in the pancreatic tissue of diabetic rats. Male Wistar rats (n = 24) were randomly divided into four groups of six animals, namely a healthy group, a healthy group receiving resveratrol, a diabetic control group, and a diabetic group receiving resveratrol. Diabetes was induced by single dose injection of streptozotocin (50 mg/kg; ip), 15 min after injection of nicotinamide (110 mg/kg; ip). Resveratrol was also administered by gavage (5 mg/kg/day) for 4 months. Administration of resveratrol alleviated hyperglycemia, weight loss and pancreatic β cell function measured by HOMA-β. Resveratrol improved oxidative stress (nitrate/nitrite, 8-isoprostane and glutathione) and proinflammatory markers (tumor necrosis factor α, cyclooxygenase 2, interleukin 6 and nuclear factor kappa B) in the pancreatic tissue of diabetic rats. Resveratrol administration had no significant effect on the activity of superoxide dismutase and catalase enzyme. These observations indicate that resveratrol administration may be effective as a beneficial factor in improving pancreatic function and reducing the complications of diabetes.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21096810.1590/s2175-97902023e21468 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21468Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21468Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e214682175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/210968/194442https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessSamin NahavandiMasoumeh RahimiMohammad Reza AlipourFarhad Ghadiri Soufi 2023-05-25T12:42:14Zoai:revistas.usp.br:article/210968Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-25T12:42:14Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
title |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
spellingShingle |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats Samin Nahavandi Hyperglycemia HOMA-β IL-6 NF-κB Resveratrol TNF-α |
title_short |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
title_full |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
title_fullStr |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
title_full_unstemmed |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
title_sort |
Long-term resveratrol administration improves diabetes-induced pancreatic oxidative stress, inflammatory status, and β cell function in male rats |
author |
Samin Nahavandi |
author_facet |
Samin Nahavandi Masoumeh Rahimi Mohammad Reza Alipour Farhad Ghadiri Soufi |
author_role |
author |
author2 |
Masoumeh Rahimi Mohammad Reza Alipour Farhad Ghadiri Soufi |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Samin Nahavandi Masoumeh Rahimi Mohammad Reza Alipour Farhad Ghadiri Soufi |
dc.subject.por.fl_str_mv |
Hyperglycemia HOMA-β IL-6 NF-κB Resveratrol TNF-α |
topic |
Hyperglycemia HOMA-β IL-6 NF-κB Resveratrol TNF-α |
description |
Diabetes is a metabolic disorder caused by insulin resistance or a defect in the pancreatic beta cells in insulin secretion. The aim of this study was to evaluate the possible effectiveness of long-term administration of resveratrol on inflammatory and oxidative stress markers in the pancreatic tissue of diabetic rats. Male Wistar rats (n = 24) were randomly divided into four groups of six animals, namely a healthy group, a healthy group receiving resveratrol, a diabetic control group, and a diabetic group receiving resveratrol. Diabetes was induced by single dose injection of streptozotocin (50 mg/kg; ip), 15 min after injection of nicotinamide (110 mg/kg; ip). Resveratrol was also administered by gavage (5 mg/kg/day) for 4 months. Administration of resveratrol alleviated hyperglycemia, weight loss and pancreatic β cell function measured by HOMA-β. Resveratrol improved oxidative stress (nitrate/nitrite, 8-isoprostane and glutathione) and proinflammatory markers (tumor necrosis factor α, cyclooxygenase 2, interleukin 6 and nuclear factor kappa B) in the pancreatic tissue of diabetic rats. Resveratrol administration had no significant effect on the activity of superoxide dismutase and catalase enzyme. These observations indicate that resveratrol administration may be effective as a beneficial factor in improving pancreatic function and reducing the complications of diabetes. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210968 10.1590/s2175-97902023e21468 |
url |
https://www.revistas.usp.br/bjps/article/view/210968 |
identifier_str_mv |
10.1590/s2175-97902023e21468 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210968/194442 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21468 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21468 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21468 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222917667061760 |