The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats

Detalhes bibliográficos
Autor(a) principal: laham, Shaza Anwar Al
Data de Publicação: 2018
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/146833
Resumo: The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney’s function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.
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spelling The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in ratsMethylsulfonylmethane (MSM)/curative effectsAcute renal failureMyoglobinuriaReactive oxygen speciesThe present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney’s function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/14683310.1590/s2175-97902018000117442Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 1 (2018); e17442Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 1 (2018); e17442Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e174422175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/146833/140362Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccesslaham, Shaza Anwar Al2018-06-07T16:31:56Zoai:revistas.usp.br:article/146833Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2018-06-07T16:31:56Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
title The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
spellingShingle The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
laham, Shaza Anwar Al
Methylsulfonylmethane (MSM)/curative effects
Acute renal failure
Myoglobinuria
Reactive oxygen species
title_short The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
title_full The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
title_fullStr The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
title_full_unstemmed The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
title_sort The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats
author laham, Shaza Anwar Al
author_facet laham, Shaza Anwar Al
author_role author
dc.contributor.author.fl_str_mv laham, Shaza Anwar Al
dc.subject.por.fl_str_mv Methylsulfonylmethane (MSM)/curative effects
Acute renal failure
Myoglobinuria
Reactive oxygen species
topic Methylsulfonylmethane (MSM)/curative effects
Acute renal failure
Myoglobinuria
Reactive oxygen species
description The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney’s function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/146833
10.1590/s2175-97902018000117442
url https://www.revistas.usp.br/bjps/article/view/146833
identifier_str_mv 10.1590/s2175-97902018000117442
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/146833/140362
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 1 (2018); e17442
Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 1 (2018); e17442
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e17442
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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