Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/26426 |
Resumo: | Aspects of biological behavior of Brazilian rabies virus isolated from canine, bovine, equine, vampire and insectivorous bats were studied in mice. The oral infection occurred in mice fed with infected brain of insectivours bat (8.82%), canine (8.57%) and equine (3.03%). The mean period of incubation to all the isolates was 6 days after mice intracerebral inoculation, however, symptoms were variable, since hyperexcitability (canine sample), progressive paralysis of lower limbs and prolonged clinical course until death (equine sample), and mice without clinical signs before death (insectivorous bat). By immunohistochemistry IFN was detected in brains of mice inoculated with bovine and insectivorous bat samples, TNF and iNOS were detected in brains of those inoculated with insectivorous bat, bovine and canine samples, and positive GFAP astrocytes were found in all five samples. Two commercial inactivated rabies vaccines, one imported (vaccine 1) and another manufactured in Brazil (vaccine 2) were compared to evaluate their efficacy to protect against experimental rabies infection in mice, through the NIH and the CDC potency tests, using these street isolates as challenge virus. There was no statistical significant difference between the efficaccy of both vaccines, when comparing the same potency test and challenge virus strain suggesting no need to produce specific vaccines with street isolates. |
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Brazilian Journal of Veterinary Research and Animal Science |
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Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raivaBiological and immunological studies of five Brazilian rabies virus isolatesVírus da raivaEstudos biológicos e imunológicosAmostras brasileirasRabies virusBiological and immunological studiesBrazilian strainsAspects of biological behavior of Brazilian rabies virus isolated from canine, bovine, equine, vampire and insectivorous bats were studied in mice. The oral infection occurred in mice fed with infected brain of insectivours bat (8.82%), canine (8.57%) and equine (3.03%). The mean period of incubation to all the isolates was 6 days after mice intracerebral inoculation, however, symptoms were variable, since hyperexcitability (canine sample), progressive paralysis of lower limbs and prolonged clinical course until death (equine sample), and mice without clinical signs before death (insectivorous bat). By immunohistochemistry IFN was detected in brains of mice inoculated with bovine and insectivorous bat samples, TNF and iNOS were detected in brains of those inoculated with insectivorous bat, bovine and canine samples, and positive GFAP astrocytes were found in all five samples. Two commercial inactivated rabies vaccines, one imported (vaccine 1) and another manufactured in Brazil (vaccine 2) were compared to evaluate their efficacy to protect against experimental rabies infection in mice, through the NIH and the CDC potency tests, using these street isolates as challenge virus. There was no statistical significant difference between the efficaccy of both vaccines, when comparing the same potency test and challenge virus strain suggesting no need to produce specific vaccines with street isolates.Estudou-se em camundongos aspectos do comportamento biológico de amostras brasileiras de virus rábico isoladas de cão, bovino, eqüino, morcegos hematófago e insetívoro. Observou-se transmissão oral em camundongos alimentados com cérebros infectados de morcego insetívoro (8,82%), cão (8,57%) e eqüino (3,03%). O período de incubação médio para todas as amostras foi de 6 dias após a inoculação intracerebral, com sintomas variando, desde hiperexitabilidade (amostra canina), paralisia progressiva principalmente de membros posteriores e maior duração do curso clínico até a morte (eqüino) e morte repentina, sem sintomas aparentes (morcego insetívoro). Pela imunoistoquímica detectou-se produção de IFN nos cérebros dos camundongos inoculados com amostra de bovino e morcego insetívoro, TNF e iNOS nos animais infectados com amostra de cão, bovino e morcego insetívoro e reação astrocitária com aumento da expressão de GFAP em todas as cinco amostras. A eficácia de 2 vacinas comerciais inativadas, uma nacional e outra importada, para a proteção contra a infecção experimental em camundongos foi avaliada através dos testes NIH e CDC, usando as amostras de campo para o desafio. Não houve diferença significativa entre o desempenho das vacinas, quando comparadas para um mesmo teste de potência e amostra de desafio sugerindo que não há necessidade de se produzir vacinas com amostras isoladas de campo.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2005-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2642610.11606/issn.1678-4456.bjvras.2005.26426Brazilian Journal of Veterinary Research and Animal Science; Vol. 42 Núm. 4 (2005); 307-312Brazilian Journal of Veterinary Research and Animal Science; Vol. 42 No. 4 (2005); 307-312Brazilian Journal of Veterinary Research and Animal Science; v. 42 n. 4 (2005); 307-312Brazilian Journal of Veterinary Research and Animal Science; V. 42 N. 4 (2005); 307-3121678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/26426/28209Bernardi, FernandaGomes, Antonio Albério de BarrosIto, Fumio HonmaiRichtzenhain, Leonardo JoséSoares, Rodrigo MartinsHeinemann, Marcos BryanCortez, AdrianaSakamoto, Sidney MioshyMaiorka, Paulo Césarinfo:eu-repo/semantics/openAccess2020-06-23T04:19:38Zoai:revistas.usp.br:article/26426Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:42:43.059195Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva Biological and immunological studies of five Brazilian rabies virus isolates |
title |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva |
spellingShingle |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva Bernardi, Fernanda Vírus da raiva Estudos biológicos e imunológicos Amostras brasileiras Rabies virus Biological and immunological studies Brazilian strains |
title_short |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva |
title_full |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva |
title_fullStr |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva |
title_full_unstemmed |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva |
title_sort |
Estudos biológicos e imunológicos de cinco amostras brasileiras do vírus da raiva |
author |
Bernardi, Fernanda |
author_facet |
Bernardi, Fernanda Gomes, Antonio Albério de Barros Ito, Fumio Honmai Richtzenhain, Leonardo José Soares, Rodrigo Martins Heinemann, Marcos Bryan Cortez, Adriana Sakamoto, Sidney Mioshy Maiorka, Paulo César |
author_role |
author |
author2 |
Gomes, Antonio Albério de Barros Ito, Fumio Honmai Richtzenhain, Leonardo José Soares, Rodrigo Martins Heinemann, Marcos Bryan Cortez, Adriana Sakamoto, Sidney Mioshy Maiorka, Paulo César |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bernardi, Fernanda Gomes, Antonio Albério de Barros Ito, Fumio Honmai Richtzenhain, Leonardo José Soares, Rodrigo Martins Heinemann, Marcos Bryan Cortez, Adriana Sakamoto, Sidney Mioshy Maiorka, Paulo César |
dc.subject.por.fl_str_mv |
Vírus da raiva Estudos biológicos e imunológicos Amostras brasileiras Rabies virus Biological and immunological studies Brazilian strains |
topic |
Vírus da raiva Estudos biológicos e imunológicos Amostras brasileiras Rabies virus Biological and immunological studies Brazilian strains |
description |
Aspects of biological behavior of Brazilian rabies virus isolated from canine, bovine, equine, vampire and insectivorous bats were studied in mice. The oral infection occurred in mice fed with infected brain of insectivours bat (8.82%), canine (8.57%) and equine (3.03%). The mean period of incubation to all the isolates was 6 days after mice intracerebral inoculation, however, symptoms were variable, since hyperexcitability (canine sample), progressive paralysis of lower limbs and prolonged clinical course until death (equine sample), and mice without clinical signs before death (insectivorous bat). By immunohistochemistry IFN was detected in brains of mice inoculated with bovine and insectivorous bat samples, TNF and iNOS were detected in brains of those inoculated with insectivorous bat, bovine and canine samples, and positive GFAP astrocytes were found in all five samples. Two commercial inactivated rabies vaccines, one imported (vaccine 1) and another manufactured in Brazil (vaccine 2) were compared to evaluate their efficacy to protect against experimental rabies infection in mice, through the NIH and the CDC potency tests, using these street isolates as challenge virus. There was no statistical significant difference between the efficaccy of both vaccines, when comparing the same potency test and challenge virus strain suggesting no need to produce specific vaccines with street isolates. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26426 10.11606/issn.1678-4456.bjvras.2005.26426 |
url |
https://www.revistas.usp.br/bjvras/article/view/26426 |
identifier_str_mv |
10.11606/issn.1678-4456.bjvras.2005.26426 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26426/28209 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 42 Núm. 4 (2005); 307-312 Brazilian Journal of Veterinary Research and Animal Science; Vol. 42 No. 4 (2005); 307-312 Brazilian Journal of Veterinary Research and Animal Science; v. 42 n. 4 (2005); 307-312 Brazilian Journal of Veterinary Research and Animal Science; V. 42 N. 4 (2005); 307-312 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051557263441920 |