Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status

Detalhes bibliográficos
Autor(a) principal: Wysoki´nski, Adam
Data de Publicação: 2019
Outros Autores: Margulska, Aleksandra, Kozłowska, Elzbieta, Brzezi´nska-Błaszczyk, Ewa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Archives of Clinical Psychiatry
Texto Completo: https://www.revistas.usp.br/acp/article/view/162188
Resumo: Background: Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives: The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods: 36 adult patients with euthymic bipolar disorder and 68 nondepressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results: There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion: Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters.
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spelling Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic statusCathelicidinLL-37bipolar disorderbody compositionBackground: Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives: The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods: 36 adult patients with euthymic bipolar disorder and 68 nondepressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results: There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion: Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters.Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2019-09-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/16218810.1590/0101-60830000000196Archives of Clinical Psychiatry; v. 46 n. 3 (2019); 66-71Archives of Clinical Psychiatry; Vol. 46 No. 3 (2019); 66-71Revista de Psiquiatria Clínica; Vol. 46 Núm. 3 (2019); 66-711806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/acp/article/view/162188/156037Wysoki´nski, AdamMargulska, AleksandraKozłowska, ElzbietaBrzezi´nska-Błaszczyk, Ewainfo:eu-repo/semantics/openAccess2019-09-12T12:30:33Zoai:revistas.usp.br:article/162188Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2019-09-12T12:30:33Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
title Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
spellingShingle Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
Wysoki´nski, Adam
Cathelicidin
LL-37
bipolar disorder
body composition
title_short Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
title_full Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
title_fullStr Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
title_full_unstemmed Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
title_sort Serum level of cathelicidin LL-37 is increased in euthymic patients with bipolar disorder irrespective of their cardio-metabolic status
author Wysoki´nski, Adam
author_facet Wysoki´nski, Adam
Margulska, Aleksandra
Kozłowska, Elzbieta
Brzezi´nska-Błaszczyk, Ewa
author_role author
author2 Margulska, Aleksandra
Kozłowska, Elzbieta
Brzezi´nska-Błaszczyk, Ewa
author2_role author
author
author
dc.contributor.author.fl_str_mv Wysoki´nski, Adam
Margulska, Aleksandra
Kozłowska, Elzbieta
Brzezi´nska-Błaszczyk, Ewa
dc.subject.por.fl_str_mv Cathelicidin
LL-37
bipolar disorder
body composition
topic Cathelicidin
LL-37
bipolar disorder
body composition
description Background: Antimicrobial peptides are components of the innate immune system. Cathelicidin LL-37 plays an important role in antimicrobial defense, exerts proinflammatory effect and strongly affects the immune system functioning. Our recent study revealed that serum concentration of LL-37 is increased in patients with bipolar disorder. Objectives: The aim of this study is to re-evaluate serum LL-37 levels in patients with euthymic bipolar disorder and in healthy controls, matched for anthropometric and body composition parameters. Methods: 36 adult patients with euthymic bipolar disorder and 68 nondepressed adults were included into the study. Concentration of LL-37 in serum was assessed using ELISA method. Detailed anthropometric measurements, body composition and biochemical analyses were performed. Results: There was a statistically significant difference (p = 0.01) in serum LL-37 level between patients with bipolar disorder (4.97 ± 7.98 ng/mL) and control subjects (1.78 ± 2.69 ng/mL). Discussion: Results of this study indicate that LL-37 serum level is increased in euthymic bipolar disorder patients. We found that this increase could not be attributed to analyzed anthropometric or body composition parameters.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/acp/article/view/162188
10.1590/0101-60830000000196
url https://www.revistas.usp.br/acp/article/view/162188
identifier_str_mv 10.1590/0101-60830000000196
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/acp/article/view/162188/156037
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
dc.source.none.fl_str_mv Archives of Clinical Psychiatry; v. 46 n. 3 (2019); 66-71
Archives of Clinical Psychiatry; Vol. 46 No. 3 (2019); 66-71
Revista de Psiquiatria Clínica; Vol. 46 Núm. 3 (2019); 66-71
1806-938X
0101-6083
reponame:Archives of Clinical Psychiatry
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Archives of Clinical Psychiatry
collection Archives of Clinical Psychiatry
repository.name.fl_str_mv Archives of Clinical Psychiatry - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||archives@usp.br
_version_ 1800237624291491840

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