Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000500801 |
Resumo: | Abstract Chronic alcohol consumption affects various neurotransmitters, especially those implicated in the transitioning to alcohol use disorders (particularly dopaminergic and CRFergic systems). Few studies have investigated moderate alcohol consumption and its harmful consequences. The objective of this work was to analyze behavioral and neurochemical (dopaminergic and CRFergic systems) alterations during chronic moderate alcohol consumption. Twelve male Wistar rats were submitted to an intermittent alcohol ingestion protocol (alcohol group) for four weeks. The control group consisted of six rats. Open Field and Elevated Plus Maze tests were used for analysis of motor and anxiety-like behaviors. Immunohistochemistry analysis was performed in dopaminergic and CRFergic systems. Animals exposed to alcohol consumed moderate doses, chronic and intermittently. Behavioral tests detected fewer fecal boli in the alcohol exposed group, and immunohistochemical analysis indicated fewer dopamine-immunoreactive cells in the ventral tegmental area, and more CRF-immunoreactive cells in the anterior cingulate cortex and dorsolateral septum in this group. Thus we concluded that Wistar rats that consumed moderate doses of alcohol voluntarily and chronically showed a discreet anxiolytic effect in behavior, and a hypodopaminergic and hyperCRFergic neurochemical condition, which together are strong inducers of alcohol consumption predisposing to the development of alcohol use disorder (AUD). |
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Effects of moderate alcohol consumption on behavior and neural systems of Wistar ratsalcoholcorticotrophin-releasing factordopaminemoderate consumptionAbstract Chronic alcohol consumption affects various neurotransmitters, especially those implicated in the transitioning to alcohol use disorders (particularly dopaminergic and CRFergic systems). Few studies have investigated moderate alcohol consumption and its harmful consequences. The objective of this work was to analyze behavioral and neurochemical (dopaminergic and CRFergic systems) alterations during chronic moderate alcohol consumption. Twelve male Wistar rats were submitted to an intermittent alcohol ingestion protocol (alcohol group) for four weeks. The control group consisted of six rats. Open Field and Elevated Plus Maze tests were used for analysis of motor and anxiety-like behaviors. Immunohistochemistry analysis was performed in dopaminergic and CRFergic systems. Animals exposed to alcohol consumed moderate doses, chronic and intermittently. Behavioral tests detected fewer fecal boli in the alcohol exposed group, and immunohistochemical analysis indicated fewer dopamine-immunoreactive cells in the ventral tegmental area, and more CRF-immunoreactive cells in the anterior cingulate cortex and dorsolateral septum in this group. Thus we concluded that Wistar rats that consumed moderate doses of alcohol voluntarily and chronically showed a discreet anxiolytic effect in behavior, and a hypodopaminergic and hyperCRFergic neurochemical condition, which together are strong inducers of alcohol consumption predisposing to the development of alcohol use disorder (AUD).Academia Brasileira de Ciências2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000500801Anais da Academia Brasileira de Ciências v.94 n.3 2022reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202220210673info:eu-repo/semantics/openAccessCONTE,RAFAELZANGIROLAME,CAROLLINE M.S.GOBBO,DENISE R.PEREIRA,LAÍS DA S.PANFILIO,CARLOS E.REGINATO,REJANE D.MALUF,LUCIANA L.S.SCERNI,DEBORA A.CÉSPEDES,ISABEL C.eng2022-07-14T00:00:00Zoai:scielo:S0001-37652022000500801Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2022-07-14T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
title |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
spellingShingle |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats CONTE,RAFAEL alcohol corticotrophin-releasing factor dopamine moderate consumption |
title_short |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
title_full |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
title_fullStr |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
title_full_unstemmed |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
title_sort |
Effects of moderate alcohol consumption on behavior and neural systems of Wistar rats |
author |
CONTE,RAFAEL |
author_facet |
CONTE,RAFAEL ZANGIROLAME,CAROLLINE M.S. GOBBO,DENISE R. PEREIRA,LAÍS DA S. PANFILIO,CARLOS E. REGINATO,REJANE D. MALUF,LUCIANA L.S. SCERNI,DEBORA A. CÉSPEDES,ISABEL C. |
author_role |
author |
author2 |
ZANGIROLAME,CAROLLINE M.S. GOBBO,DENISE R. PEREIRA,LAÍS DA S. PANFILIO,CARLOS E. REGINATO,REJANE D. MALUF,LUCIANA L.S. SCERNI,DEBORA A. CÉSPEDES,ISABEL C. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
CONTE,RAFAEL ZANGIROLAME,CAROLLINE M.S. GOBBO,DENISE R. PEREIRA,LAÍS DA S. PANFILIO,CARLOS E. REGINATO,REJANE D. MALUF,LUCIANA L.S. SCERNI,DEBORA A. CÉSPEDES,ISABEL C. |
dc.subject.por.fl_str_mv |
alcohol corticotrophin-releasing factor dopamine moderate consumption |
topic |
alcohol corticotrophin-releasing factor dopamine moderate consumption |
description |
Abstract Chronic alcohol consumption affects various neurotransmitters, especially those implicated in the transitioning to alcohol use disorders (particularly dopaminergic and CRFergic systems). Few studies have investigated moderate alcohol consumption and its harmful consequences. The objective of this work was to analyze behavioral and neurochemical (dopaminergic and CRFergic systems) alterations during chronic moderate alcohol consumption. Twelve male Wistar rats were submitted to an intermittent alcohol ingestion protocol (alcohol group) for four weeks. The control group consisted of six rats. Open Field and Elevated Plus Maze tests were used for analysis of motor and anxiety-like behaviors. Immunohistochemistry analysis was performed in dopaminergic and CRFergic systems. Animals exposed to alcohol consumed moderate doses, chronic and intermittently. Behavioral tests detected fewer fecal boli in the alcohol exposed group, and immunohistochemical analysis indicated fewer dopamine-immunoreactive cells in the ventral tegmental area, and more CRF-immunoreactive cells in the anterior cingulate cortex and dorsolateral septum in this group. Thus we concluded that Wistar rats that consumed moderate doses of alcohol voluntarily and chronically showed a discreet anxiolytic effect in behavior, and a hypodopaminergic and hyperCRFergic neurochemical condition, which together are strong inducers of alcohol consumption predisposing to the development of alcohol use disorder (AUD). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000500801 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000500801 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202220210673 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.94 n.3 2022 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302872126750720 |