Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000200005 |
Resumo: | We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-<FONT FACE=Symbol>g</font> and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host. |
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Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruziTrypanosoma cruziprotectioncytokineshumoral responseWe have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-<FONT FACE=Symbol>g</font> and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host.Academia Brasileira de Ciências2003-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000200005Anais da Academia Brasileira de Ciências v.75 n.2 2003reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652003000200005info:eu-repo/semantics/openAccessSoares,Milena B. P.Gonçalves,RenataPyrrho,Alexandre S.Costa,Deise A.Paiva,Claudia N.Gattass,Cerli R.eng2003-07-31T00:00:00Zoai:scielo:S0001-37652003000200005Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2003-07-31T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
title |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
spellingShingle |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi Soares,Milena B. P. Trypanosoma cruzi protection cytokines humoral response |
title_short |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
title_full |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
title_fullStr |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
title_full_unstemmed |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
title_sort |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
author |
Soares,Milena B. P. |
author_facet |
Soares,Milena B. P. Gonçalves,Renata Pyrrho,Alexandre S. Costa,Deise A. Paiva,Claudia N. Gattass,Cerli R. |
author_role |
author |
author2 |
Gonçalves,Renata Pyrrho,Alexandre S. Costa,Deise A. Paiva,Claudia N. Gattass,Cerli R. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Soares,Milena B. P. Gonçalves,Renata Pyrrho,Alexandre S. Costa,Deise A. Paiva,Claudia N. Gattass,Cerli R. |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi protection cytokines humoral response |
topic |
Trypanosoma cruzi protection cytokines humoral response |
description |
We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-<FONT FACE=Symbol>g</font> and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652003000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652003000200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.75 n.2 2003 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302855818248192 |