Green coffee extract attenuates Parkinson’s-related behaviors in animal models
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800602 |
Resumo: | Abstract Epidemiological studies have shown an inverse association between coffee consumption and the development of Parkinson’s disease (PD). The effects of the oral treatment with green (non-roasted) coffee extracts (CE, 100 or 400 mg/kg) and caffeine (31.2 mg/kg) were evaluated on catalepsy induced by haloperidol in mice, and unilateral 6-OHDA lesion of medial forebrain bundle (MFB) or striatum in rats. Also, the in vitro antioxidant activity and the monoamine levels in the striatum were investigated. CE presented a mild antioxidant activity in vitro and its administration decreased the catalepsy index. CE at the dose of 400 mg/kg induced ipsilateral rotations 14 days after lesion; however, chronic 30-day CE and caffeine treatments did not interfere with the animals’ rotation after apomorphine or methamphetamine challenges in animals with MFB lesion, nor on monoamines levels. Furthermore, CE and caffeine were effective in inhibiting the asymmetry between ipsilateral and contralateral rotations induced by methamphetamine and apomorphine in animals with lesion in the striatum but did not avoid the monoamines depletion. These results indicate that CE components indirectly modulate dopaminergic transmission, suggesting a pro-dopaminergic action of CE, and further investigation must be conducted to elucidate the mechanisms of action and the possible neuroprotective role in PD. |
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Green coffee extract attenuates Parkinson’s-related behaviors in animal modelsCoffea arabicaParkinson’s diseasecatalepsychlorogenic acidscaffeineneuroprotectionAbstract Epidemiological studies have shown an inverse association between coffee consumption and the development of Parkinson’s disease (PD). The effects of the oral treatment with green (non-roasted) coffee extracts (CE, 100 or 400 mg/kg) and caffeine (31.2 mg/kg) were evaluated on catalepsy induced by haloperidol in mice, and unilateral 6-OHDA lesion of medial forebrain bundle (MFB) or striatum in rats. Also, the in vitro antioxidant activity and the monoamine levels in the striatum were investigated. CE presented a mild antioxidant activity in vitro and its administration decreased the catalepsy index. CE at the dose of 400 mg/kg induced ipsilateral rotations 14 days after lesion; however, chronic 30-day CE and caffeine treatments did not interfere with the animals’ rotation after apomorphine or methamphetamine challenges in animals with MFB lesion, nor on monoamines levels. Furthermore, CE and caffeine were effective in inhibiting the asymmetry between ipsilateral and contralateral rotations induced by methamphetamine and apomorphine in animals with lesion in the striatum but did not avoid the monoamines depletion. These results indicate that CE components indirectly modulate dopaminergic transmission, suggesting a pro-dopaminergic action of CE, and further investigation must be conducted to elucidate the mechanisms of action and the possible neuroprotective role in PD.Academia Brasileira de Ciências2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800602Anais da Academia Brasileira de Ciências v.93 suppl.4 2021reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202120210481info:eu-repo/semantics/openAccessMOLSKA,GRAZIELLA R.PAULA-FREIRE,LYVIA IZAURA G.SAKALEM,MARNA E.KÖHN,DANIELE O.NEGRI,GIUSEPPINACARLINI,ELISALDO A.MENDES,FÚLVIO R.eng2021-10-28T00:00:00Zoai:scielo:S0001-37652021000800602Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2021-10-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
title |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
spellingShingle |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models MOLSKA,GRAZIELLA R. Coffea arabica Parkinson’s disease catalepsy chlorogenic acids caffeine neuroprotection |
title_short |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
title_full |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
title_fullStr |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
title_full_unstemmed |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
title_sort |
Green coffee extract attenuates Parkinson’s-related behaviors in animal models |
author |
MOLSKA,GRAZIELLA R. |
author_facet |
MOLSKA,GRAZIELLA R. PAULA-FREIRE,LYVIA IZAURA G. SAKALEM,MARNA E. KÖHN,DANIELE O. NEGRI,GIUSEPPINA CARLINI,ELISALDO A. MENDES,FÚLVIO R. |
author_role |
author |
author2 |
PAULA-FREIRE,LYVIA IZAURA G. SAKALEM,MARNA E. KÖHN,DANIELE O. NEGRI,GIUSEPPINA CARLINI,ELISALDO A. MENDES,FÚLVIO R. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
MOLSKA,GRAZIELLA R. PAULA-FREIRE,LYVIA IZAURA G. SAKALEM,MARNA E. KÖHN,DANIELE O. NEGRI,GIUSEPPINA CARLINI,ELISALDO A. MENDES,FÚLVIO R. |
dc.subject.por.fl_str_mv |
Coffea arabica Parkinson’s disease catalepsy chlorogenic acids caffeine neuroprotection |
topic |
Coffea arabica Parkinson’s disease catalepsy chlorogenic acids caffeine neuroprotection |
description |
Abstract Epidemiological studies have shown an inverse association between coffee consumption and the development of Parkinson’s disease (PD). The effects of the oral treatment with green (non-roasted) coffee extracts (CE, 100 or 400 mg/kg) and caffeine (31.2 mg/kg) were evaluated on catalepsy induced by haloperidol in mice, and unilateral 6-OHDA lesion of medial forebrain bundle (MFB) or striatum in rats. Also, the in vitro antioxidant activity and the monoamine levels in the striatum were investigated. CE presented a mild antioxidant activity in vitro and its administration decreased the catalepsy index. CE at the dose of 400 mg/kg induced ipsilateral rotations 14 days after lesion; however, chronic 30-day CE and caffeine treatments did not interfere with the animals’ rotation after apomorphine or methamphetamine challenges in animals with MFB lesion, nor on monoamines levels. Furthermore, CE and caffeine were effective in inhibiting the asymmetry between ipsilateral and contralateral rotations induced by methamphetamine and apomorphine in animals with lesion in the striatum but did not avoid the monoamines depletion. These results indicate that CE components indirectly modulate dopaminergic transmission, suggesting a pro-dopaminergic action of CE, and further investigation must be conducted to elucidate the mechanisms of action and the possible neuroprotective role in PD. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800602 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000800602 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202120210481 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.93 suppl.4 2021 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302871198760960 |